Protein Alignment Sema5c and Sema5b

DIOPT Version :10

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: XP_006521932.1
• Gene: Sema5b / 20357
• MGIID: 107555
• Length: 1122
• Species: Mus musculus
• Alignment Length: 1146
• Identity: 411/1146 - (35%)
• Similarity: 580/1146 - (50%)
• Gaps: 181/1146 - (15%)

  Fly    15 LWLLLILSLLTLEGPQPSTGSGYTTKSSVD---LLENDSRYISYQDLMSTAKRFYDPETTWYSEM 76
            |.|.|:||.|||.....|:.....::||.:   ....:...::::||......|..|....:|::
Mouse     7 LALSLLLSSLTLLVSHLSSSQDIASESSSEQQMCTRREHPIVAFEDLKPWVFNFTYPGVRDFSQL 71

  Fly    77 LFDVARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGE 140
            ..|.:|||:|||||:.|:|:|. ::..|:...|.::......||:||::|..|:||||||...|
Mouse    72 ALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVSG- 135

  Fly   141 NQLYACGTNAFQPSCSWRQMENLTVTGVD--SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSG 203
            .:::.||||||.|.||.||:.||:.| ::  :||.:||:.|:.|||:::.|.|:|:..|..||||
Mouse   136 RKVFMCGTNAFSPVCSSRQVGNLSRT-IEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSG 199

  Fly   204 SDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVA 268
            .|.||.|: :.|... |||.|||:.||:...||.:|:.|.|.||.|||:|.|| .||:.:|||||
Mouse   200 RDPAIYRS-LGSGPP-LRTAQYNSKWLNEPNFVAAFDIGLFAYFFLRENAVEH-DCGRTVYSRVA 261

  Fly   269 RVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSIF 333
            ||||||| ||..||.|.||:|:|||||||.|||.|:|::|:|...:...:.::|..|.|:.:||.
Mouse   262 RVCKNDV-GGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIA 325

  Fly   334 GSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQFQCGT------------SSIGHWLE 386
            .|||||:|||:|:.||:|||:.||:..|||..: .|....|||||            .|:   .:
Mouse   326 ASAVCAFNLSAISKAFNGPFRYQENPRAAWLPI-ANPIPNFQCGTLPETGPNENLTERSL---QD 386

  Fly   387 SSRYQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVAS-SGNHIKKLSVKYDGD 450
            :.|..||.|||||:..||.......:|..|.:|::..|....|||::.: ||..:|.||..  ..
Mouse   387 AQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTA--SR 449

  Fly   451 GVQTC-LVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPY 514
            .::.| |.||..........|.::..|..:.:|::|....:.|:|.:.||.:.||.:||.:.|||
Mouse   450 SLRGCYLEELHVLPPGRLEPLRSLRILHSARALFVGLSDRVLRVPLERCSAYHSQGACLGARDPY 514

  Fly   515 CGWNELVERCMPQPQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDS-NCQCR 578
            |||:...:.|... :|||.:..|.| ...||||.|...|||:..||||..|:..:..:| :|.||
Mouse   515 CGWDGKRQLCSTL-EDSSNMSLWIQ-NITTCPVRNVTRDGGFGPWSPWKPCEHLDGDNSGSCLCR 577

  Fly   579 QRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFGG 643
            .|||::|:|:.||..|.|.|..:.||:::|.||.||:|:.||.:|||..::|:|:|.||.|..||
Mouse   578 ARSCDSPRPRCGGLECLGPSIHIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCSNPAPRHGG 642

  Fly   644 RTCVGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGGM 708
            |.|||..:.|.:|....||||..      .|..||.||:||..||||.:.|||.|.:      |.
Mouse   643 RICVGKSREERFCNENTPCPVPI------FWASWGSWSKCSNNCGGGVQSRRRSCEN------GN 695

  Fly   709 ECPGCRL-----------------------------DYEECNMQSCQEVRKLSAWTPWL--TVTG 742
            .||||.:                             :::.||.::|.|||:.:.|||||  .||.
Mouse   696 SCPGCGVVRSRGWGAGSGETYSPGGVGGSEATLTPKEFKTCNPEACPEVRRNTPWTPWLPVNVTQ 760

  Fly   743 SGNSSEPHMERRFRFVCRATSPDPSSVRIGLPKEESRNCHADGSCQRQVDHDSADSDA------- 800
            .|    ...|:||||.|||..|||..::.|..:.|:|.|.|||:       .:.|:||
Mouse   761 GG----ARQEQRFRFTCRAPLPDPHGLQFGKRRTETRTCPADGT-------GACDTDALVEDLLR 814

  Fly   801 ----------------ADWSPCSVSCGGGVQQRHR---------------GRGSQSRVCNIHACP 834
                            ..||.||..|..|.:.|.|               |..::.:.||..|||
Mouse   815 SGSTSPHTLNGGWATWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACP 879

  Fly   835 AEEQLSSNSLDNELEHGEWGCWSEWSACSVTCGLGLRRRTRRCLA-----GHDRLCQGRALEEQK 894
            .              .|.|.||:.||.||.:||.|..:|||.|.:     |.| :|.|...||..
Mouse   880 V--------------RGAWSCWTAWSQCSASCGGGHYQRTRSCTSPAPSPGED-ICLGLHTEEAL 929

  Fly   895 CEMVPCEDFLGWSAWSEWSSCSSDGIRLRHRRCLVEQPGSMECRGAEFEKTAC----VP-----N 950
            |....|.:  |||.||||..|:.||.:.|.|.|....||...|.|...:...|    :|     :
Mouse   930 CSTQACPE--GWSLWSEWGVCTEDGAQSRSRSCEELLPGPGACVGNSSQSRPCPYSEIPVILPAS 992

  Fly   951 ECEETQTASTATLPIVIFVGLLFTVACCLATYRFTKKRFMLSAEEALNKTTTTTASFDTYPN--Q 1013
            ..|||.:.....|..:|..|    |:|.|.:...|...: ||.:....::..:|......||  .
Mouse   993 SVEETTSCGGFNLIHLIVTG----VSCFLVSGLLTLAVY-LSCQHCQRQSQESTLVHPATPNHLH 1052

  Fly  1014 YSSLPTKDYYDQRPKRQSSFRMPAKTSNLGNGNGTLNRNNM 1054
            |....|       ||.:....|..|         |||:||:
Mouse  1053 YKGGGT-------PKNEKYTPMEFK---------TLNKNNL 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	185/447 (41%)
		PSI	497..546	CDD:396154	19/48 (40%)
		TSP1	556..607	CDD:214559	21/51 (41%)
		TSP1	610..663	CDD:214559	25/52 (48%)
		TSP1	674..725	CDD:214559	22/79 (28%)
		TSP1	802..834	CDD:214559	12/46 (26%)
		TSP1	853..901	CDD:214559	21/52 (40%)
		TSP1	906..953	CDD:214559	18/55 (33%)
Sema5b	XP_006521932.1	Sema	60..496	CDD:472829	185/447 (41%)
		PSI	497..544	CDD:396154	19/48 (40%)
		TSP1	609..662	CDD:214559	25/52 (48%)
		TSP1	667..742	CDD:214559	22/80 (28%)
		TSP1	827..879	CDD:214559	12/51 (24%)
		TSP1	884..936	CDD:214559	21/52 (40%)
		TSP_1	940..981	CDD:459668	15/40 (38%)