DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and Sema4f

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_035480.3	Gene:	Sema4f / 20355	MGIID:	1340055	Length:	777	Species:	Mus musculus

Alignment Length:	656	Identity:	167/656 - (25%)
Similarity:	276/656 - (42%)	Gaps:	121/656 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVAR 82
            ||:|.|..|..|..........::|:.:.|.|| |::         ||..|.|..||.:|.|.|.
Mouse    26 LLLLLLAMLSAPVCGRVPRSVPRTSLPISEADS-YLT---------RFAAPHTYNYSALLVDPAS 80

  Fly    83 NQVIVGARDTLYRMS--FDLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYA 145
            :.:.|||||:::.::  |..|...|..|....:....|:.||:.|..|.|::::|.....:.|..
Mouse    81 HTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLT 145

  Fly   146 CGTNAFQPSC------SWRQMENLTVTGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGS 204
            |||.||.|.|      |::|:|.|     :||..||||.|...|.::: :.|.|:..|..:|.|:
Mouse   146 CGTFAFDPKCGVIDVSSFQQVERL-----ESGRGKCPFEPAQRSAAVM-AGGVLYTATVKNFLGT 204

  Fly   205 DVAILRTGVESNKRFLRTKQYNNNWLSGAQFV----------GSFEAGHFVYFLLRESAAEHMSC 259
            :..|.| .|...:.::||:.. ::||:...||          |..:....::|...|::....|.
Mouse   205 EPIISR-AVGRAEDWIRTETL-SSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSY 267

  Fly   260 GKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPG-EYPYYFDEIQGMTYAESE----- 318
            .::...||||||..|: ||.:.|:..||:||||.|.|  || |:......:|.||....:
Mouse   268 ERIKVPRVARVCAGDL-GGRKTLQQRWTTFLKADLLC--PGPEHGRASGVLQDMTELRPQPGAGT 329

  Fly   319 SILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQRSQ---FQCGTSS 380
            .:.|..|.:.......|||||:....|.|..:|||::.:|.......|..|:..|   .:|.|::
Mouse   330 PLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNN 394

  Fly   381 IGHWLESSR-------------YQLMDEAVQPIGAEPLYHSKLEQFGR-LALDIINTKTEQVHVL 431
            :......|.             :.|||..|.|....||..:....:.| :|..:.:...::..||
Mouse   395 MKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEYDVL 459

  Fly   432 FVASSGNHIKKLSVKYDGDGVQTCLVE-LWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPA 495
            ::.:...|:.: :|:.   |.|..::| |....:|.....:.:.:    |.|.:|:...:|::..
Mouse   460 YLGTEDGHLHR-AVRI---GAQLSVLEDLALFPETQPVESMKLYH----DWLLVGSHTEVTQVNT 516

  Fly   496 QHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQIT--CP--------VLNA 550
            .:|.|..|.|.|:.:.||.|.|:..::.|:....:...:....::..::  ||        |...
Mouse   517 SNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEV 581

  Fly   551 PIDG------GWSTWSPWAVCQQHEQPDS-----------------------NCQCRQRSCNNPQ 586
            |:..      ..|..|.||.|..| ||..                       .|:|
Mouse   582 PVATVGHVVLPCSPSSAWASCVWH-QPSGVTSLTPRRDGLEVVVTPGAMGAYACEC--------- 636

  Fly   587 PQHGGA 592
             |.|||
Mouse   637 -QEGGA 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	127/472 (27%)
		PSI	497..546	CDD:279745	10/50 (20%)
		TSP1	556..607	CDD:214559	14/60 (23%)
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema4f	NP_035480.3	Sema_4F	58..517	CDD:200522	130/487 (27%)
		PSI	518..569	CDD:279745	10/50 (20%)
		Ig	576..655	CDD:299845	16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..742
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11483650	775..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820