DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and Sema4c

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_006495867.1	Gene:	Sema4c / 20353	MGIID:	109252	Length:	943	Species:	Mus musculus

Alignment Length:	540	Identity:	159/540 - (29%)
Similarity:	242/540 - (44%)	Gaps:	87/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ISYQDLMSTAKRFYDP--------ETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLE---RA 106
            :|..:|::..:||...        ..|.:|.:|:        ||||:.|:  :|.:|.||   ..
Mouse   142 VSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLY--------VGAREALF--AFSVEALELQGAI 196

  Fly   107 SWGATPSEIAMCQAKGQSERW-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTV--TGV 168
            ||.|...:...|..||:|.:. |.|::|.|..|..:.||.|||.||||.|::..|...|:  ...
Mouse   197 SWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEF 261

  Fly   169 DSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILR-TGVESNKRFLRTKQYNNNWLSG 232
            :.|..|||:.|....|.|| .:|:|:..|..:|.|::..||| .|...:   ::| :|...||:.
Mouse   262 EDGKGKCPYDPAKGHTGLL-VDGELYSATLNNFLGTEPVILRYMGTHHS---IKT-EYLAFWLNE 321

  Fly   233 AQFVGSF----EAGHF------VYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWT 287
            ..||||.    ..|.|      :||...|.|.|:....:.:.:|||||||.|: ||.:.|:..||
Mouse   322 PHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDM-GGARTLQKKWT 385

  Fly   288 SFLKARLNCSLPGEYPYYFDEIQGMTYAESES----ILYATFRTSGSSIFGSAVCAYNLSSINAA 348
            :||||||.||.| ::..||::::.:......|    ..:..|:.....:..||||.|.|..|...
Mouse   386 TFLKARLVCSAP-DWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQV 449

  Fly   349 FDGPFKQQEHSDAAWKTVNTNQRSQFQCGTSSIGHWLESSRY-----------------QLMDEA 396
            |:||:|  |:|:.|.|..............|.|.:|...:.|                 .||::.
Mouse   450 FEGPYK--EYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQ 512

  Fly   397 VQPIGAEPLYHSKLEQFGRLALDII-----NTKTEQVHVLFVAS-SGNHIKKLSVKYDGDGVQTC 455
            |:|....||...|...|..:..|.:     .|.|    |||:.: .|..:|.:|:     |....
Mouse   513 VKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYT----VLFIGTGDGWLLKAVSL-----GPWIH 568

  Fly   456 LVELWQA-DDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNE 519
            :||..|. |.....||:.....||   |:.|:...|.::....|:::.....|:.:.||||.||.
Mouse   569 MVEELQVFDQEPVESLVLSQSKKV---LFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNV 630

  Fly   520 LVERCMPQPQDSS---VLQH 536
            ...||:......|   ::||
Mouse   631 NTSRCVATTSGRSGSFLVQH 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	143/483 (30%)
		PSI	497..546	CDD:279745	13/43 (30%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Sema4c	XP_006495867.1	Sema_4C	151..607	CDD:200519	144/486 (30%)
		PSI	608..>637	CDD:214655	10/28 (36%)
		Ig	673..757	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810