DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and C36B7.5

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001359920.1	Gene:	C36B7.5 / 180975	WormBaseID:	WBGene00016468	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	957	Identity:	215/957 - (22%)
Similarity:	313/957 - (32%)	Gaps:	368/957 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 IYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFD--------EIQGMTYAESES 319
            |..|::::.::.:..|.:...||     ||||..:.   :|...|        :::|..||...|
Worm   114 ITHRISKLHRDALSDGRESENDN-----KARLADAF---FPENRDHVGSDDEFKLEGERYAVMRS 170

  Fly   320 ILYATFRTSGSSIFGSAVCAYNLSSI--NAAFDGP-FKQQEHS-----------DAAW-KTVNTN 369
            |.....:           .|.|...:  :...||| |.|..|.           |..: ||::..
Worm   171 IEEVEIQ-----------AAKNREELPRDPFSDGPRFHQSSHERDRGDDTDRQRDREYLKTIDYT 224

  Fly   370 QRSQFQCGTSSIGHWLESSRYQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVA 434
            ::|:.....:.|....:||         |.:.|.|:
Worm   225 EKSERPIHPTIIHRGQQSS---------QQMSASPV----------------------------- 251

  Fly   435 SSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCS 499
            :|||.....:         .|...|:|.|.....:             .||...|    |.:.|.
Worm   252 ASGNPCLPNA---------ACARTLYQMDTAPCPA-------------RLGDPCA----PKRPCM 290

  Fly   500 R----HVSQ--------------SSCLNSMDPYCGWNELVERCM-------PQPQDSSVLQHWHQ 539
            .    ||:.              |.|..|    ||.:....:|:       |.
Worm   291 NDDCYHVAPPGQAAPPVVEWTEWSECSAS----CGISLRTRQCLGGITCIGPS------------ 339

  Fly   540 APQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQC----RQRSCNNPQPQHGGATCEGISTQ 600
              .|.|.|....:   |:.||||::|      .:.|..    |.|.|..      |..|:|.|.:
Worm   340 --TIPCQVPECAV---WTLWSPWSLC------TATCGVGEIQRNRVCQT------GRNCDGPSVE 387

  Fly   601 VTNC-------TQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGN----PRPAFGGRTCVGSEQSEM 654
            |..|       |    |:.|.:|:.|..:||.:::.|.|.|.|    |.||...|||
Worm   388 VEACKALLPCPT----WSSWMSWTGCGNSCGKSIERRSRICQNGLLCPGPATEERTC-------- 440

  Fly   655 YCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGGMECPGCRLDYEE 719
               ...|||         .|..||:|.:||.:||.|...|.|||.|      |:.|.|...:...
Worm   441 ---DKRPCP---------HWSNWGQWEKCSKECGAGHTYRNRECID------GVSCEGASEEKIL 487

  Fly   720 CNMQSCQEVRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDPSSVRIGLPK----EESRN 780
            ||.|.|.|   .|.||.|.                   ||.....: .|:|:...|    |.:..
Worm   488 CNQQPCPE---WSQWTAWT-------------------VCDERCGE-ESIRLRNRKCMNAENNNA 529

  Fly   781 CHADGSCQRQVDHDSAD----SDAADWSPCSVSCGGGVQQRHR---------GRGSQSRVCNIHA 832
            |  ||..|.|:.....|    .:..:|:.||.:||.|.|:|.|         |.|.:.|.|.|.:
Worm   530 C--DGPAQDQMSCPYRDCPKWEEWGEWADCSTTCGQGTQKRLRKCDSGNECSGPGEEMRFCQIAS 592

  Fly   833 CPAEEQLSSNSLDNELEHGEWGCWSEWSACSVTCGLGLRRRTRRC-------------------L 878
            ||                 .||.|:.||.|||:||.|:..|||:|                   |
Worm   593 CP-----------------YWGDWTPWSGCSVSCGQGVCERTRKCITDEFLQLPTLEELERDDSL 640

  Fly   879 AGHD---------------------RL---------------CQGRALEEQKCEMVPCEDFLGWS 907
            ..|:                     ||               |.|..:|.:.|:..||   ..|:
Worm   641 EKHEAKEALIARAKTISKYRRTNETRLSPFRPLSPEPQLGGTCDGPEMETKVCDAGPC---CVWN 702

  Fly   908 AWSEWS---SCSSDGIRLRHRRCLVEQPGSMECRGAEFEKTACVPNECEETQTASTATLPI--VI 967
            .|:|||   .|.::||..|:|.|      |||.:.......:...|......|||....||  .|
Worm   703 RWTEWSPCIGCGNEGISKRNRVC------SMEGQSPAPPPISFQDNPRGTYVTASLGQGPIGPNI 761

  Fly   968 FVGLLFTVACCLATYRFTKKRFMLSAEEALNKTTTTTASFDTYP----------------NQYSS 1016
            ..|:...|.  :..:|  .||.:|...:|..|......:|.|.|                :::..
Worm   762 LPGMSPIVP--VEIHR--GKRQVLFGIQATPKCHCPGDTFQTRPCLEQNACQDPVGKCEWSEWGE 822

  Fly  1017 -------LPTKD----YYDQRPKRQSSFRMPAKTSNLGNGNGTLNRN 1052
                   .|.|:    :.|:.|..:.....|..|.:.|||:.:..|:
Worm   823 WCGCMRCRPGKEVRRRFCDRSPIGRGGPMRPDSTCDCGNGDDSQERS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	45/255 (18%)
		PSI	497..546	CDD:279745	11/73 (15%)
		TSP1	556..607	CDD:214559	17/61 (28%)
		TSP1	610..663	CDD:214559	17/56 (30%)
		TSP1	674..725	CDD:214559	20/50 (40%)
		TSP1	802..834	CDD:214559	14/40 (35%)
		TSP1	853..901	CDD:214559	24/102 (24%)
		TSP1	906..953	CDD:214559	15/49 (31%)
C36B7.5	NP_001359920.1	TSP1	309..348	CDD:214559	10/56 (18%)
		TSP1	351..398	CDD:214559	16/58 (28%)
		TSP1	400..446	CDD:214559	17/56 (30%)
		TSP1	448..494	CDD:214559	20/51 (39%)
		TSP1	496..546	CDD:214559	16/71 (23%)
		TSP1	548..594	CDD:214559	14/45 (31%)
		TSP1	596..>621	CDD:214559	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840