DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA4B

DIOPT Version :9

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_001310963.1 Gene:SEMA4B / 10509 HGNCID:10730 Length:847 Species:Homo sapiens


Alignment Length:780 Identity:196/780 - (25%)
Similarity:308/780 - (39%) Gaps:182/780 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVA 81
            |||:|.||.|:.|.|:.  ..:.:.|:.|...:..::          ||.....:.|:.:|....
Human    26 LLLLLLLLLLQPPPPTW--ALSPRISLPLGSEERPFL----------RFEAEHISNYTALLLSRD 78

  Fly    82 RNQVIVGARDTLYRMSFDLEPL-----ERASWGATPSEIAMCQAKGQS-ERWCRNYVRVLHSYGE 140
            ...:.||||:.|:.:|.:|..|     :...|||...:...|..||:. :|.|:||:::|.....
Human    79 GRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSG 143

  Fly   141 NQLYACGTNAFQPSCSWRQMENLTVTGVDSGVV-------KCPFHPQANSTSLLQSNGQLFVGTA 198
            :.|:.|||.||.|.|::..|||.|:...:.|.|       :|||.|...||:|: .:|:|:.||.
Human   144 SHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALV-VDGELYTGTV 207

  Fly   199 TDFSGSDVAILRTGVESNKRFLR-TKQYNN-NWLSGAQFV---------GSFEA-GHFVYFLLRE 251
            :.|.|:|.||      |..:.|| ||..:: |||....||         ||.:. ...:||...|
Human   208 SSFQGNDPAI------SRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSE 266

  Fly   252 SAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGE-YPYYFDEIQGM-TY 314
            :..|.......|.||:||:||.| .||.::|:..|||||||:|.||.|.: :|  |:.:|.: |.
Human   267 TGQEFEFFENTIVSRIARICKGD-EGGERVLQQRWTSFLKAQLLCSRPDDGFP--FNVLQDVFTL 328

  Fly   315 AES-----ESILYATFRTS--GSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVN----T 368
            :.|     :::.|..|.:.  ..:..|||||.:.:..:...|.|.:|:.......|.||.    |
Human   329 SPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPT 393

  Fly   369 NQRSQFQCGTSSIGHWLESSRYQLMDEAVQ----------PIGAEPLYHSKLEQFGRLALDIINT 423
            .:..  .|.|:|......:|..||.|..:.          .:.:..|......::.|:|:..:..
Human   394 PRPG--ACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPG 456

  Fly   424 KTEQVHVLFVASSGNHI-KKLSVKYDGDGVQTCLVELWQADDTG--TSSLLNMAYLKVS------ 479
            ......|||:.:....: |.:||     |.:..::|..|...:|  ..:||...: :||      
Human   457 LHHTYDVLFLGTGDGRLHKAVSV-----GPRVHIIEELQIFSSGQPVQNLLLDTH-RVSRPTRNP 515

  Fly   480 --DSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQH--WHQA 540
              ..||..:...:.::|..:||.:.|...||.:.||||.|:            .|..:|  .:| 
Human   516 GRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWS------------GSSCKHVSLYQ- 567

  Fly   541 PQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQ--PQHGGATCEGISTQVTN 603
            ||:..              .||  .|..|...:...|...|..:|.  |. |...||.:..|...
Human   568 PQLAT--------------RPW--IQDIEGASAKDLCSASSVVSPSFVPT-GEKPCEQVQFQPNT 615

  Fly   604 CTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFGGRTC----------VGSEQ-SEMYCR 657
            ...          ..|.....:|.::..|   |..|.....:|          ||::| .|..|.
Human   616 VNT----------LACPLLSNLATRLWLR---NGAPVNASASCHVLPTGDLLLVGTQQLGEFQCW 667

  Fly   658 HLPP---------CP----------------------VAKPQSVDGGWGPWGE----WSECSAQC 687
            .|..         ||                      .::..:..||...||.    |.|....|
Human   668 SLEEGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLVMC 732

  Fly   688  687
            Human   733  732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 136/489 (28%)
PSI 497..546 CDD:279745 15/50 (30%)
TSP1 556..607 CDD:214559 12/52 (23%)
TSP1 610..663 CDD:214559 12/72 (17%)
TSP1 674..725 CDD:214559 5/18 (28%)
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
SEMA4BNP_001310963.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..815
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41799at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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