Protein Alignment Sema5c and SEMA4D

DIOPT Version :10

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: NP_006369.3
• Gene: SEMA4D / 10507
• HGNCID: 10732
• Length: 862
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 179/692 - (25%)
• Similarity: 282/692 - (40%)
• Gaps: 164/692 - (23%)

  Fly    64 RFYDPETTWYSEMLFDVARNQVIVGARDTLYRM-SFDL-EPLERASWGATPSEIAMCQAKGQSER 126
            :|::|:...||.:|....::.:.:|||:.::.: :.:: |......|..:..:.|.|..||:|::
Human    41 QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQ 105

  Fly   127 W-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGV-DSGVVKCPFHPQANSTSLLQS 189
            . |.||:|||.......||.||||||||:|....:.:....|. :.|..:|||.|..:.||:: .
Human   106 TECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVM-V 169

  Fly   190 NGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFV-------------GSFEA 241
            :|:|:.||:.:|.||:..|.|....|.   ||| :|...||:...||             |..:.
Human   170 DGELYSGTSYNFLGSEPIISRNSSHSP---LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDR 230

  Fly   242 GHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYF 306
               |||...|.:.|:....:|:..|:|||||.| .||.:.|:..|||||||||.||.| :....|
Human   231 ---VYFFFTEVSVEYEFVFRVLIPRIARVCKGD-QGGLRTLQKKWTSFLKARLICSRP-DSGLVF 290

  Fly   307 DEIQGMTYAESES----ILYATFRTSGSSIFGSAVCAYNLSSINAAFD-GPFKQQ---EHSDAAW 363
            :.::.:....|..    :.||.|....:::..|||||||||:....|. |.:.|.   |.|...|
Human   291 NVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKW 355

  Fly   364 KTVN-----------TNQRSQFQCGTSSIGHWLESSRYQ------LMDEAVQPIGAEPLYHSKLE 411
            ...|           .:..::....|||:.  |.....|      |||::|.||...|....|..
Human   356 VRYNGPVPKPRPGACIDSEARAANYTSSLN--LPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDV 418

  Fly   412 QFGRLALDIINTKTEQVH-VLFVASS-GNHIKKLSVKY------------DGDGVQTCLVELWQA 462
            .:.::.:|........|: |:||::. |...|.:|:::            |.:.|||.|
Human   419 NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLL------ 477

  Fly   463 DDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQ 527
                      ::..|.:..:|.|::..:.:.|...|.:|.:...|:.:.||||.|:
Human   478 ----------LSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWS--------- 523

  Fly   528 PQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGA 592
                        .|..||..|:       .|.||.....|....|::. |..:| .....||
Human   524 ------------PPTATCVALH-------QTESPSRGLIQEMSGDASV-CPDKS-KGSYRQH--- 564

  Fly   593 TCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIA---VKIRRRTCGNPRPAFG--GR-------- 644
                       ..:|||..|..    |||...:|   .|.:........|.:|  ||
Human   565 -----------FFKHGGTAELK----CSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNL 614

  Fly   645 --------TCVGSEQ------SEMYCRH-----LPPCPVAKP 667
                    .|:..|:      .::..:|     :.|.||..|
Human   615 SEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAP 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	138/486 (28%)
		PSI	497..546	CDD:396154	10/48 (21%)
		TSP1	556..607	CDD:214559	9/50 (18%)
		TSP1	610..663	CDD:214559	14/84 (17%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
SEMA4D	NP_006369.3	Sema_4D	31..501	CDD:200520	138/487 (28%)
		PSI	503..554	CDD:396154	17/79 (22%)
		Ig_Sema4D_like	559..645	CDD:409457	18/103 (17%)
		Ig strand A	559..565	CDD:409457	2/19 (11%)
		Ig strand B	569..577	CDD:409457	3/11 (27%)
		Ig strand C	583..589	CDD:409457	1/5 (20%)
		Ig strand C'	591..594	CDD:409457	0/2 (0%)
		Ig strand D	600..604	CDD:409457	1/3 (33%)
		Ig strand E	607..614	CDD:409457	0/6 (0%)
		Ig strand F	620..629	CDD:409457	1/8 (13%)
		Ig strand G	633..645	CDD:409457	1/11 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..837