DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA4D

DIOPT Version :9

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_001358123.1 Gene:SEMA4D / 10507 HGNCID:10732 Length:862 Species:Homo sapiens


Alignment Length:692 Identity:179/692 - (25%)
Similarity:282/692 - (40%) Gaps:164/692 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 RFYDPETTWYSEMLFDVARNQVIVGARDTLYRM-SFDL-EPLERASWGATPSEIAMCQAKGQSER 126
            :|::|:...||.:|....::.:.:|||:.::.: :.:: |......|..:..:.|.|..||:|::
Human    41 QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQ 105

  Fly   127 W-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGV-DSGVVKCPFHPQANSTSLLQS 189
            . |.||:|||.......||.||||||||:|....:.:....|. :.|..:|||.|..:.||:: .
Human   106 TECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVM-V 169

  Fly   190 NGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFV-------------GSFEA 241
            :|:|:.||:.:|.||:..|.|....|.   ||| :|...||:...||             |..:.
Human   170 DGELYSGTSYNFLGSEPIISRNSSHSP---LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDR 230

  Fly   242 GHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYF 306
               |||...|.:.|:....:|:..|:|||||.| .||.:.|:..|||||||||.||.| :....|
Human   231 ---VYFFFTEVSVEYEFVFRVLIPRIARVCKGD-QGGLRTLQKKWTSFLKARLICSRP-DSGLVF 290

  Fly   307 DEIQGMTYAESES----ILYATFRTSGSSIFGSAVCAYNLSSINAAFD-GPFKQQ---EHSDAAW 363
            :.::.:....|..    :.||.|....:::..|||||||||:....|. |.:.|.   |.|...|
Human   291 NVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKW 355

  Fly   364 KTVN-----------TNQRSQFQCGTSSIGHWLESSRYQ------LMDEAVQPIGAEPLYHSKLE 411
            ...|           .:..::....|||:.  |.....|      |||::|.||...|....|..
Human   356 VRYNGPVPKPRPGACIDSEARAANYTSSLN--LPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDV 418

  Fly   412 QFGRLALDIINTKTEQVH-VLFVASS-GNHIKKLSVKY------------DGDGVQTCLVELWQA 462
            .:.::.:|........|: |:||::. |...|.:|:::            |.:.|||.|      
Human   419 NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLL------ 477

  Fly   463 DDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQ 527
                      ::..|.:..:|.|::..:.:.|...|.:|.:...|:.:.||||.|:         
Human   478 ----------LSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWS--------- 523

  Fly   528 PQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGA 592
                        .|..||..|:       .|.||.....|....|::. |..:| .....||   
Human   524 ------------PPTATCVALH-------QTESPSRGLIQEMSGDASV-CPDKS-KGSYRQH--- 564

  Fly   593 TCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIA---VKIRRRTCGNPRPAFG--GR-------- 644
                       ..:|||..|..    |||...:|   .|.:........|.:|  ||        
Human   565 -----------FFKHGGTAELK----CSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNL 614

  Fly   645 --------TCVGSEQ------SEMYCRH-----LPPCPVAKP 667
                    .|:..|:      .::..:|     :.|.||..|
Human   615 SEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAP 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 138/486 (28%)
PSI 497..546 CDD:279745 10/48 (21%)
TSP1 556..607 CDD:214559 9/50 (18%)
TSP1 610..663 CDD:214559 14/84 (17%)
TSP1 674..725 CDD:214559
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
SEMA4DNP_001358123.1 Sema_4D 31..501 CDD:200520 138/487 (28%)
PSI 503..554 CDD:214655 17/79 (22%)
Ig_Sema4D_like 559..645 CDD:143281 18/103 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..837
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41799at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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