DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA4F

DIOPT Version :10

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_004254.2 Gene:SEMA4F / 10505 HGNCID:10734 Length:770 Species:Homo sapiens


Alignment Length:656 Identity:168/656 - (25%)
Similarity:267/656 - (40%) Gaps:125/656 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVARNQ 84
            :|.|..|.||..........::|:.:.|.|          |...||..|.|..||.:|.|.|.:.
Human    22 LLLLAVLSGPVSGRVPRSVPRTSLPISEAD----------SCLTRFAVPHTYNYSVLLVDPASHT 76

  Fly    85 VIVGARDTLYRMS--FDLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYACG 147
            :.||||||::.:|  |..|...|..|....:....|:.||:.|..|.|:|::|.....:.|..||
Human    77 LYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCG 141

  Fly   148 TNAFQPSCS------WRQMENLTVTGVDSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDV 206
            |.||.|.|.      ::|:|.|     :||..||||.|...|.::: :.|.|:..|..::.|::.
Human   142 TFAFDPKCGVIDVSRFQQVERL-----ESGRGKCPFEPAQRSAAVM-AGGVLYAATVKNYLGTEP 200

  Fly   207 AILRTGVESNKRFLRTKQYNNNWLSGAQFV----------GSFEAGHFVYFLLRESAAEHMSCGK 261
            .|.| .|...:.::||... .:||:...||          |..:....:||...|::....|..:
Human   201 IITR-AVGRAEDWIRTDTL-PSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYER 263

  Fly   262 VIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPG-EYPYYFDEIQGMTYAESE-----SI 320
            :...||||||..|: ||.:.|:..||:||||.|.|  || |:......:|.:.....|     .|
Human   264 IKVPRVARVCAGDL-GGRKTLQQRWTTFLKADLLC--PGPEHGRASSVLQDVAVLRPELGAGTPI 325

  Fly   321 LYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTN---QRSQFQCGTSS-- 380
            .|..|.:.......|||||:....|....:|||::.:|.......|..|   |....:|.|::  
Human   326 FYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMK 390

  Fly   381 IGHWLES-----------SRYQLMDEAVQPIGAEPLYHSKLEQFGR-LALDIINTKTEQVHVLFV 433
            :.|:..|           ..:.|||..|.|....||..:....:.| :|..:.:...::..||::
Human   391 LRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYL 455

  Fly   434 ASSGNHIKKLSVKYDGDGVQTCLVE---LWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPA 495
            .:...|:.: :|:.   |.|..::|   |:.......:..|..::|.|      |:...:|::..
Human   456 GTEDGHLHR-AVRI---GAQLSVLEDLALFPEPQPVENMKLYHSWLLV------GSRTEVTQVNT 510

  Fly   496 QHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQIT--CP--------VLNA 550
            .:|.|..|.|.|:.:.||.|.|:..::.|:....:...|....::..::  ||        |...
Human   511 TNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEV 575

  Fly   551 PIDGG------WSTWSPWAVCQQHEQPDS-----------------------NCQCRQRSCNNPQ 586
            |:...      .|..|.||.|..| ||..                       .|:|         
Human   576 PVATAAHVVLPCSPSSAWASCVWH-QPSGVTALTPRRDGLEVVVTPGAMGAYACEC--------- 630

  Fly   587 PQHGGA 592
             |.|||
Human   631 -QEGGA 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 129/474 (27%)
PSI 497..546 CDD:396154 11/50 (22%)
TSP1 556..607 CDD:214559 14/60 (23%)
TSP1 610..663 CDD:214559
TSP1 674..725 CDD:214559
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
SEMA4FNP_004254.2 Sema_4F 52..511 CDD:200522 131/479 (27%)
PSI 512..563 CDD:396154 11/50 (22%)
Sema4F_C 576..770 CDD:437260 15/71 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 696..725
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9Z123 768..770
Blue background indicates that the domain is not in the aligned region.

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