DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and SEMA6B

DIOPT Version :10

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:NP_115484.2 Gene:SEMA6B / 10501 HGNCID:10739 Length:888 Species:Homo sapiens


Alignment Length:476 Identity:164/476 - (34%)
Similarity:247/476 - (51%) Gaps:49/476 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 VIVGARDTLYRMSFDLEP--------LERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGEN 141
            :.:|.||.|||:  :|||        ..:.:|.:.||:|.:|:.||:.|..|||:|:||....|:
Human    77 LFIGDRDNLYRV--ELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDES 139

  Fly   142 QLYACGTNAFQPSCSWRQMENLTVTGVD-SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSD 205
            .|:.||:|||.|.|:...::.|...|.: ||:.:||:.|:..:.:|. |:|.||..|.|||...|
Human   140 TLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALF-SDGMLFTATVTDFLAID 203

  Fly   206 VAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARV 270
            ..|.|:  ..::..|||.::::.|.....||.:.|.|..|||..||.|.|.....||:.||||||
Human   204 AVIYRS--LGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARV 266

  Fly   271 CKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAES---ESILYATFRTSGSSI 332
            |||||||..::|...||||||||||||:||:..:||:.:|.:|...|   ..::.|.|.|..:||
Human   267 CKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSI 331

  Fly   333 FGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTNQ--RSQFQCGTSSIGHWLESS------- 388
            .||||||::|:.:.|.|:|.|::|:..::.|..|..:|  |.:..|..:....:..||       
Human   332 PGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDIL 396

  Fly   389 ----RYQLMDEAVQPIGAEPLYHSKL--EQFGRLALDIINTKTEQVHVLFVASSGNHIKKLSVKY 447
                .:.||||||..:|..|.....|  .|..|:|:|:.........|:|:.|....:.|..|:.
Human   397 NFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRP 461

  Fly   448 DG-----DGVQTCL--VELWQAD--------DTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQH 497
            :.     .|:...|  .|.::.|        :|| ..||::.....|..|.......:.|:|...
Human   462 NASTSGTSGLSVFLEEFETYRPDRCGRPGGGETG-QRLLSLELDAASGGLLAAFPRCVVRVPVAR 525

  Fly   498 CSRHVS-QSSCLNSMDPYCGW 517
            |.::.. ..:|:.|.||||||
Human   526 CQQYSGCMKNCIGSQDPYCGW 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 155/452 (34%)
PSI 497..546 CDD:396154 9/22 (41%)
TSP1 556..607 CDD:214559
TSP1 610..663 CDD:214559
TSP1 674..725 CDD:214559
TSP1 802..834 CDD:214559
TSP1 853..901 CDD:214559
TSP1 906..953 CDD:214559
SEMA6BNP_115484.2 Sema_6B 57..524 CDD:200528 155/452 (34%)
PSI 525..>554 CDD:396154 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..679
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..742
PHA03247 <706..888 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..888
Blue background indicates that the domain is not in the aligned region.

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