DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and SEMA6C

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001171532.1	Gene:	SEMA6C / 10500	HGNCID:	10740	Length:	962	Species:	Homo sapiens

Alignment Length:	952	Identity:	250/952 - (26%)
Similarity:	378/952 - (39%)	Gaps:	218/952 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KLPKMFSQLWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETT 71
            :.|.....|.|||:|||       |.|.:.:         ..|...:...||..|:      ..:
Human     3 RAPHFMPLLLLLLLLSL-------PHTQAAF---------PQDPLPLLISDLQGTS------PLS 45

  Fly    72 WY---------SEMLFDVAR-----NQVIVGARDTLYRMSFDLEPLERASWGATPS--------E 114
            |:         :|:..|..|     ..::|.|||.::  ||||:..|... |..|:        :
Human    46 WFRGLEDDAVAAELGLDFQRFLTLNRTLLVAARDHVF--SFDLQAEEEGE-GLVPNKYLTWRSQD 107

  Fly   115 IAMCQAKGQSERWCRNYVRVLHSYGENQLYACGTNAFQPSCSWRQMENLTVTGVD-SGVVKCPFH 178
            :..|..:|:....|.||:|||..:....|.|||||:|.|.|....:.:|...|.: ||..:|||.
Human   108 VENCAVRGKLTDECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFD 172

  Fly   179 PQANSTSLLQSNGQLFVGTATDFSGSDVAILRT-GVESNKRFLRTKQYNNNWLSGAQFVGSFEAG 242
            ...::.::. :.|.|:..||.||..||..:.|: |.:..   ||:.:|::.||....||.:.|.|
Human   173 ATQSNVAIF-AEGSLYSATAADFQASDAVVYRSLGPQPP---LRSAKYDSKWLREPHFVQALEHG 233

  Fly   243 HFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFD 307
            ..|||..||.:.|....|:|.:||||||||.|:||..:.|..:||||||.|||||:||:..:|||
Human   234 DHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFD 298

  Fly   308 EIQGMT---YAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVNTN 369
            .:|.:|   .....|.|:..|.|..:||.||||||:.|..|...|:|.||:|...|.||..|:.:
Human   299 VLQALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSED 363

  Fly   370 QRSQFQCGT-SSIG--HWLESSR------------YQLMDEAVQPIGAEPLY----HSKLEQFGR 415
            :....:.|: :.:|  ....|||            :.|:|.||.|:..:||.    .:.|.|
Human   364 RVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSRALLTQ--- 425

  Fly   416 LALDIINTKTEQVHVLFVASS-GNHIKKLSVKYDGDGVQTCLVELWQADDTGTSS---------- 469
            :|:|.:......:.|:|:.|: |..:|.|:......|.:..|:|...|......|
Human   426 VAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCSGKRTAQTARR 490

  Fly   470 LLNMAYLKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGWNELVERC--------- 524
            ::.:........|::.....:..:|...|:|| ..|.|||.|.||||||:. ...|
Human   491 IIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGWHS-SRGCVDIRGSGGT 554

  Fly   525 -MPQPQDSSVLQHW---------HQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSN-CQCR 578
             :.|..:...::|.         ...|..:..||..|   |.|..:|......|.:|.|: ....
Human   555 DVDQAGNQESMEHGDCQDGATGSQSGPGDSAYVLPGP---GPSPGTPSPPSDAHPRPQSSTLGVH 616

  Fly   579 QRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKI------RRR----- 632
            .|......|....:....|...:.:..        :|::..:...|:.|..      |||
Human   617 TRGVRRDLPPASASRSVPIPLLLASVA--------AAFALGASVSGLLVSCACRRAHRRRGKDIE 673

  Fly   633 TCGNPRP--------AFGGRTCVGSE------------QSEMYCRHLPP----------C---PV 664
            |.|.|||        ..||    |.|            ..::|...|||          |   |.
Human   674 TPGLPRPLSLRSLARLHGG----GPEPPPPSKDGDAVQTPQLYTTFLPPPEGVPPPELACLPTPE 734

  Fly   665 AKPQ----SVDGGWGPWGEWSE--CSAQCGGGFRMRRRECNDPAPL-------NGGMECPGCRLD 716
            :.|:    .:.....|| ||::  .:|:.|.|..........|||.       .|   |||
Human   735 STPELPVKHLRAAGDPW-EWNQNRNNAKEGPGRSRGGHAAGGPAPRVLVRPPPPG---CPG---- 791

  Fly   717 YEECNMQSCQE-VRKLSAWTPWLTVTGSGNSSEPHMERRFRFVCRATSPDPSSVRIGLPKEESRN 780
             :...:.:.:| :|.|....|      ....:||...    ...||..|:|:...:|.|......
Human   792 -QAVEVTTLEELLRYLHGPQP------PRKGAEPPAP----LTSRALPPEPAPALLGGPSPRPHE 845

  Fly   781 CHA--------DGSCQRQVDHDSADSDAADWSPC-SVSCGGG 813
            |.:        :|.|.      ||.:..|..:|. .:..|||
Human   846 CASPLRLDVPPEGRCA------SAPARPALSAPAPRLGVGGG 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	148/487 (30%)
		PSI	497..546	CDD:279745	18/68 (26%)
		TSP1	556..607	CDD:214559	8/51 (16%)
		TSP1	610..663	CDD:214559	20/96 (21%)
		TSP1	674..725	CDD:214559	14/59 (24%)
		TSP1	802..834	CDD:214559	4/13 (31%)
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
SEMA6C	NP_001171532.1	Sema	53..517	CDD:301699	147/473 (31%)
SEMA6C	NP_001171532.1	PSI	518..570	CDD:279745	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810