DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema5c and sema5b

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_031748739.1	Gene:	sema5b / 100493363	XenbaseID:	XB-GENE-959729	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	1165	Identity:	388/1165 - (33%)
Similarity:	570/1165 - (48%)	Gaps:	198/1165 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKLPKMFSQLWLL---LILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYD 67
            |..|:..:.|.|.   |..|.:.:|.|:    ..|.::....:|       |:|:|......|..
Frog    17 LPRPRALTALSLFIFHLSASQVAVETPE----KDYCSRREHPIL-------SFQELKPWLSNFTF 70

  Fly    68 PETTWYSEMLFDVARNQVIVGARDTLYRMSF-DLEPLERASWGATPSEIAMCQAKGQSERWCRNY 131
            .:...:|::..|:.|||:|||||:.|:|:|. ::..::.|.|.:.......||:||::|..|:||
Frog    71 SDVRDFSQLALDLNRNQLIVGARNYLFRLSLHNVSLIQAAEWSSDEDTQRSCQSKGKTEDECQNY 135

  Fly   132 VRVLHSYGENQLYACGTNAFQPSCSWRQMENLT-VTGVDSGVVKCPFHPQANSTSLLQSNGQLFV 195
            ||||...|: :::.||||||.|.|:.||:.||: |....:||.:||:.|:.|||:::.:.|:|:.
Frog   136 VRVLIVSGK-RVFTCGTNAFSPVCTSRQVGNLSKVIEKINGVARCPYDPRHNSTAVMTTRGELYA 199

  Fly   196 GTATDFSGSDVAILRT--GVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMS 258
            .|..||||.|..|.|:  .|..    |||.|||:.||:...||.:::.|.|.||..||:|.|| .
Frog   200 ATVIDFSGRDPVIYRSLGSVPP----LRTAQYNSKWLNEPNFVAAYDIGIFTYFFFRENAVEH-D 259

  Fly   259 CGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYA 323
            |||.:|||||||||||. ||..||.|.||:|:|||||||.|||.|:|::|:|.......:.::|.
Frog   260 CGKTVYSRVARVCKNDY-GGRFLLEDTWTTFMKARLNCSRPGEIPFYYNELQSTFLLPEQDLIYG 323

  Fly   324 TFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAW-KTVNTNQRSQFQCG---TSSIGHW 384
            .|.|:.:||..|||||:|||:|..||:|||:.||:..:|| .|:  |....||||   ..|....
Frog   324 VFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLPTI--NPIPNFQCGILNDDSPNEN 386

  Fly   385 L------ESSRYQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVHVLFVASS-GNHIKK 442
            |      ::.|..||::.|||:..|||......:|.:|.:||:..|....||:::.:. |..:|.
Frog   387 LTERSLQDAQRLFLMNDVVQPVSVEPLVTQDSVRFSKLVVDIVQGKDTLYHVMYIGTEHGTILKA 451

  Fly   443 LSVKYDGDGVQTCLVELWQADDTGTSS-LLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSS 506
            ||..  ...:::|.:|.......|... :.::..|..:.||::|.:..:.::|.:.||.:.::..
Frog   452 LSTA--NRSLRSCYLEEMHILPIGQQEPIRSLQILHSNRSLFVGLNNGVLKVPLERCSIYRTEGD 514

  Fly   507 CLNSMDPYCGWNELVERCMPQPQDSSVLQHWHQAPQ--ITCPVLNAPIDGGWSTWSPWAVCQQHE 569
            .|.:.||||||:...:||.|     ....|:...|:  ::|||....:.||...|  | |..:|.
Frog   515 RLGARDPYCGWDSKKKRCTP-----XAYPHYITGPRNTLSCPVSGLTVHGGRGAW--W-VRAKHS 571

  Fly   570 QPDSNCQCR-QRSCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRT 633
            .......|. .|.|:||.|:.||..|:|...::.||:::||||.||:|:.||.:|||..::|:||
Frog   572 PTGLFGLCPFPRVCDNPLPRCGGRDCDGTRIEIANCSRNGGWTPWSSWAQCSTSCGIGFQVRQRT 636

  Fly   634 CGNPRPAFGGRTCVGSEQSE--------MYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGG 690
            |.||.|...||.|||..:.|        ::|....||||..      .|..||.|::||:.||||
Frog   637 CSNPAPRCXGRVCVGQSREERVKMMLDGLFCNENSPCPVPI------FWTSWGSWTKCSSDCGGG 695

  Fly   691 FRMRRRECNDPAPLNGGMECPGCRLDYEECNMQSCQEVRKLSAWTPW--LTVTGSGNSSEPHMER 753
            ...|:|.|.:      |..||||.:::..||.:.|.|||:.:.||||  :.:|..|    ...|:
Frog   696 THSRQRSCEN------GNTCPGCAMEFRPCNSEPCPEVRRNTPWTPWTPVNITQGG----ARQEQ 750

  Fly   754 RFRFVCRATSPDPSSVRIGLPKEESRNCHADGSCQRQVDHDSAD----------------SDAAD 802
            |||:.|||...||.:::.|..|.|:|.|..|||...:.|....|                |..:.
Frog   751 RFRYTCRAQLADPHNLQFGRKKTETRFCPNDGSAACETDTLVDDLMRNSKTPGRTVSGGWSPWSG 815

  Fly   803 WSPCSVSCGGGVQQRHR---------------GRGSQSRVCNIHACPAEEQLSSNSLDNELEHGE 852
            ||.||..|..|.:.|.|               |...:.:.||...||.:              |.
Frog   816 WSSCSRECELGFRTRKRTCSNPEPRNGGLPCAGSAMEYQDCNPQPCPVK--------------GS 866

  Fly   853 WGCWSEWSACSVTCGLGLRRRTRRCL-----AGHDRLCQGRALEEQKCEMVPCEDFLGWSAWSEW 912
            |.|||.|:.||.|||.|..:|||.|.     .|.| :|.|...||..|...|||.  ||:.||||
Frog   867 WSCWSPWTQCSATCGGGHYQRTRTCTNPPPSNGGD-ICIGLHTEEALCNTYPCEG--GWAEWSEW 928

  Fly   913 SSCSSDGIRLRHRRCLVEQPGSMECRGAEFEKTACVPNECEETQTASTATLPIVI---------- 967
            |.|..||.:.|:|.|.:..||..:|.|...:...|:.||           :|:::
Frog   929 SMCHEDGSQYRNRYCEIHNPGPTQCLGNSTQFRDCIYNE-----------IPVILPASSIDENSE 982

  Fly   968 -----FVGLLFT-VACCLATYRFTKKRFML--SAEEALNKTTTTTASFDTYPN--QYSSLPTKDY 1022
                 .:.|:.| |:|...:...|   |::  ..:....::..:|......||  .|....|
Frog   983 CGGFSLIHLIATGVSCFFGSSLLT---FVIYVYCQRCQRQSQESTVIHPATPNHLHYKGSST--- 1041

  Fly  1023 YDQRPKRQSSFRMPAKTSNLGNGNGTLNRNN-----------MHQNNT------PKVLAK 1065
                ||.:....|..|         |||:||           :.|.|.      |..|:|
Frog  1042 ----PKNEKYTPMEFK---------TLNKNNLLPDDRTNFYPLQQTNVYTTTYYPSTLSK 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	175/446 (39%)
		PSI	497..546	CDD:279745	14/50 (28%)
		TSP1	556..607	CDD:214559	16/51 (31%)
		TSP1	610..663	CDD:214559	25/60 (42%)
		TSP1	674..725	CDD:214559	20/50 (40%)
		TSP1	802..834	CDD:214559	11/46 (24%)
		TSP1	853..901	CDD:214559	23/52 (44%)
		TSP1	906..953	CDD:214559	19/46 (41%)
sema5b	XP_031748739.1	Sema_5B	68..504	CDD:200525	175/446 (39%)
		PSI	505..>533	CDD:214655	10/27 (37%)
		TSP1	613..674	CDD:214559	25/60 (42%)
		TSP1	679..725	CDD:214559	20/51 (39%)
		TSP1	810..862	CDD:214559	12/51 (24%)
		TSP1	867..919	CDD:214559	23/52 (44%)
		TSP1	922..963	CDD:214559	16/40 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11235
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41799at33208
OrthoFinder	1	1.000	-	-		FOG0003495
OrthoInspector	1	1.000	-	-		oto103053
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	1	1.000	-	-		X2388
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.000