DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema6a

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_017946194.2	Gene:	sema6a / 100493034	XenbaseID:	XB-GENE-980417	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	158/526 - (30%)
Similarity:	263/526 - (50%)	Gaps:	69/526 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GPQPSTGSGYTTKSSVDL----LENDSRYISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVG 88
            |.:|  |...|.:..:|:    :.|.:.||:.:|.:.|.    |.||::..|:.|.
Frog    43 GHKP--GRNSTQRHKMDIQQIVIMNRTLYIAARDHIYTV----DLETSYTEEIFFS--------- 92

  Fly    89 ARDTLYRMSFDLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYACGTNAFQP 153
                           ::.:|.:..|::..|:.||:.:..|.|:::||....|:.|:.||||||.|
Frog    93 ---------------KKLTWKSKQSDVDTCRMKGKHKDECHNFIKVLLKRDEDTLFVCGTNAFNP 142

  Fly   154 SCSWRQMENLTVTGVD-SGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNK 217
            ||.:.:|:.|.....: ||:.:||:..:..:.:|. ::|:|:..|.|||...|..|.|:  ..:.
Frog   143 SCRYYKMDTLEFLDEEISGMARCPYDAKHANVALF-ADGKLYSATVTDFLAIDAVIYRS--LGDG 204

  Fly   218 RFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLL 282
            ..|||.:|::.||....||.:.:.|..:||..||.|.|:.|.|||::.|||:|||||:||..::|
Frog   205 PTLRTVKYDSKWLKEPYFVHAVDYGDLIYFFYREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVL 269

  Fly   283 RDNWTSFLKARLNCSLPGEYPYYFDEIQGMT---YAESESILYATFRTSGSSIFGSAVCAYNLSS 344
            ...||||||||||||:||:..:||:.:|.:|   :.....::.|||.|..:||.|||||||:::.
Frog   270 EKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHINGRDVVLATFSTPYNSIPGSAVCAYDMAD 334

  Fly   345 INAAFDGPFKQQEHSDAAWKTVNTNQ----RSQFQCGTSSIGHWLESSR-----------YQLMD 394
            |.:.|.|.||:|:..|:.|..|...:    |.....|::::....:|:.           :.|||
Frog   335 IASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSATVERITKSNELPDDTLNFIKTHPLMD 399

  Fly   395 EAVQPIGAEPLYHSKLEQF--GRLALDIINTKTEQVHVLFVASSGNHIKKLSVK--YDG------ 449
            |||..:...||:...:.::  .::|:|......:...|:|:.|....:.|...:  |.|
Frog   400 EAVPSVINRPLFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSERGIVLKFLARTGYSGFLSDSL 464

  Fly   450 --DGVQTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVS-QSSCLNSM 511
              :.:.....|....|......:|.|...|.:::||:.....:..:|...|.||.. :.:|:.|.
Frog   465 FLEEMNVYNSEKCSFDGAEDKRILGMQLDKHNNALYVAFSTCVVSVPLARCDRHTKCKKTCIASR 529

  Fly   512 DPYCGW 517
            ||||.|
Frog   530 DPYCVW 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	138/461 (30%)
		PSI	497..546	CDD:279745	10/22 (45%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema6a	XP_017946194.2	Sema	48..513	CDD:417757	145/495 (29%)
sema6a	XP_017946194.2	PSI	514..>544	CDD:396154	10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000