Protein Alignment Sema5c and adamts2

DIOPT Version :10

• Sequence 1: NP_611293.3
• Gene: Sema5c / 37066
• FlyBaseID: FBgn0284221
• Length: 1093
• Species: Drosophila melanogaster
• Sequence 2: XP_012815203.2
• Gene: adamts2 / 100492431
• XenbaseID: XB-GENE-492342
• Length: 1170
• Species: Xenopus tropicalis
• Alignment Length: 1285
• Identity: 240/1285 - (18%)
• Similarity: 376/1285 - (29%)
• Gaps: 496/1285 - (38%)

  Fly    90 RDTLYRMSFDLEPLERASWGATPSEIAMCQAKGQSERWCRNYVRVLHSYGENQLYACGTNAFQPS 154
            ||:|      |:.||..|. .||   ....:||:       ||....:..|...|....:..:.:
 Frog    29 RDSL------LKKLEEYSL-VTP---VSTDSKGK-------YVSHSVTKRETHRYRRDASNLEKT 76

  Fly   155 CSWRQMENLTVTG--------VDSGVV----KCPFHPQANSTSLLQSNGQ-LFVGTATDFSGSDV 206
            .:.|...|:||.|        |:|.:|    ...:...||.|.:...|.. |:||..||...:.|
 Frog    77 SAERIYYNVTVFGREFHLKLRVNSKLVAPGATIEWEEDANVTVIEPLNTNCLYVGDITDLPNASV 141

  Fly   207 AILRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVC 271
            ||                .|.:.|:|  .:.:.|...|:..|.::...|......::|.|.| |.
 Frog   142 AI----------------SNCDGLAG--IIRTEEEEFFIEPLEKDKEGEDEGRVHIVYRRSA-VL 187

  Fly   272 KNDVGGGGQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTYAESESILYATFRTSGSSIFG-- 334
            |:..|....:..:..|.            ..|...:.|......:..|....|.|.:....|.
 Frog   188 KSFQGNNTDIQLNETTQ------------HSPNLLENIIDNVQEQVNSTRKRTRRHASDDDFNIE 240

  Fly   335 ---------------SAVCAYNLSSINAAFDGPFKQQEHSDAAWKTVN-----------TNQRSQ 373
                           ..|..|.|:.:|..     .:..|.::....:|           :...|.
 Frog   241 ILLGVDDSVVQFHGKEYVQKYLLTLLNIV-----NEIYHDESLGAHINVVLVRIIMLSHSKSSSL 300

  Fly   374 FQCGTSSIGHWLES-SRYQLMDEAVQPIGAEPLYHSKL-----EQFGRLALDIINTKTEQVH--- 429
            .:.|..|  ..||: .|:..:.:..:...||  ||...     ::||...:......|...|
 Frog   301 IEVGNPS--QSLENVCRWAYLQQKPETGHAE--YHDHAIFLTRQEFGPSGMQGYAPVTGMCHPVR 361

  Fly   430 ------------VLFVASSGNHIKKLSVKYDGDGVQTCLVELWQADDTGTSSLLNMAYLKVSDSL 482
                        ...||....|:  |.:::||.| ..|                       .|.:
 Frog   362 SCTLNHEDGFSSAFVVAHETGHV--LGMEHDGQG-NRC-----------------------GDEV 400

  Fly   483 YLGTDLA-----------LTRIPAQHCSRHVSQSSCLNSMDPYCGWNELVERCMPQPQDSSVLQH 536
            .:|:.:|           .:|...|..||:::...||.. ||:                    :|
 Frog   401 RMGSIMAPLVQAAFHRFHWSRCSQQELSRYLNSYDCLRD-DPF--------------------EH 444

  Fly   537 -WHQAPQITCPVLN------APIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSCNNPQPQHGGATC 594
             |...||:  |.::      ...|.|..    :.:|......|   .|:|..|::....:...|.
 Frog   445 NWPSLPQL--PGIHYSMNEQCRFDFGLG----YMMCTAFRTFD---PCKQLWCSHTDNPYFCKTK 500

  Fly   595 EGISTQVTNCT-------------------QHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPA 640
            :|.....|.|:                   |.|.|.:||.:..||::||..|:.|.|:|.||.||
 Frog   501 KGPPLDGTMCSYGKHCFKGHCIWLTPDILRQDGNWGQWSKFGSCSRSCGTGVRYRTRSCDNPHPA 565

  Fly   641 FGGRTCVGSEQSEMYCRHLPPC----------------PVAKPQSVDGGWGPW---GEWSECSAQ 686
            .|||:|.|.......| :...|                |..:.|.....|.|:   .|...|...
 Frog   566 NGGRSCSGPSYELQLC-NTEDCKTDFDDFREEQCKQWDPYFEYQDSKHNWLPYDHPDEKERCHLY 629

  Fly   687 CGGGFRMRRRECNDPAPLNGGMECPGCRLDYE---------ECNMQSCQEVRKLSAWTPWLTVTG 742
            |      :.:|..|...:. .:...|.|..|:         ||....|.:|...........|.|
 Frog   630 C------QSKETGDVVYMK-RLTHDGTRCSYKDSYNICVRGECLKVGCDKVIGSKKKEDKCGVCG 687

  Fly   743 SGNS----------SEPHMERRFR--------------------------------FVC---RAT 762
            ..||          ..|..:...|                                |:.   ..|
 Frog   688 GDNSHCKVVKGTFTRTPRKQGNVRIFEIPVGARHLLIQETGASIHNLAIKNQASGKFILNDENVT 752

  Fly   763 SPD------------------------------PSSVRIGLPKEESR-------NCHADGSCQRQ 790
            .||                              |.::.: :|:..|:       ..|.|..   .
 Frog   753 LPDSKIFVNMGIEWEYQNDDNRETVQTMGPLHNPITILV-IPRGHSKISLSYKYMIHEDSF---N 813

  Fly   791 VDHDSADSDAA--------DWSPCSVSCGGGVQQRHRGRGSQS--------------------RV 827
            ||:::...|..        .||.||..||||.|....|...:|                    ||
 Frog   814 VDNNNVVEDVVVTYEWTLKKWSHCSKPCGGGHQFTKYGCRRKSDHKMVHKNFCDSIQKLKPIRRV 878

  Fly   828 CNIHACPAEEQLSSNSLDNELEHGEWGCWSEWSACSVTCG-LGLRRRTRRCL---------AGHD 882
            ||:..|.....:|                .||..|:|||| .|.:.||.:|:         :.|:
 Frog   879 CNLQECSQPLWIS----------------GEWEPCTVTCGKSGYQFRTVKCIQPLNDNKNRSVHN 927

  Fly   883 RLC-QGRALEEQKCEMVPCEDFLGWSAW--SEWSSCS---SDGIRLRHRRCLVEQPGSMECRGAE 941
            :.| ..|...::.|...||.     :.|  ..||.||   .:|...|...|           |::
 Frog   928 KYCSDDRPEAKRPCNRQPCP-----AQWRIGPWSQCSVTCGNGTEERQVHC-----------GSD 976

  Fly   942 FEKTACVPNE-------CEETQTASTATLP---------------------------------IV 966
            ..|:|....|       |..:..:..|:.|                                 :|
 Frog   977 INKSANCSEEKPETIRICRLSPCSGNASDPYKKNYIVQWLSKLDPDYPLHKISSKESCLEDKSMV 1041

  Fly   967 IFVGLL--------FTVACCL---ATYRFTKKRFMLSAEEAL---------NKTTTTTASFDTYP 1011
            ..:|:|        ::..||.   |:..:...:...|::.||         |.|.|.|..   |.
 Frog  1042 CRLGILQRYCSVPGYSRMCCKACNASQLYNDSKMNSSSDPALPIPSPPTLYNTTVTFTPD---YK 1103

  Fly  1012 NQYSSLPTKDYYDQR--------------------PKRQSSFRMPAKTSN 1041
            ...|:....|.::.|                    |:|:|:|   .:|.|
 Frog  1104 QNVSNPNITDQHNNRVDVPYKIQELQNEVPQLNAIPRRRSTF---GRTKN 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	87/478 (18%)
		PSI	497..546	CDD:396154	10/49 (20%)
		TSP1	556..607	CDD:214559	9/69 (13%)
		TSP1	610..663	CDD:214559	22/68 (32%)
		TSP1	674..725	CDD:214559	12/62 (19%)
		TSP1	802..834	CDD:214559	15/51 (29%)
		TSP1	853..901	CDD:214559	16/58 (28%)
		TSP1	906..953	CDD:214559	12/58 (21%)
adamts2	XP_012815203.2	Pep_M12B_propep	41..181	CDD:460254	35/168 (21%)
		ZnMc_ADAMTS_like	238..438	CDD:239801	36/234 (15%)
		ADAMTS_CR_2	453..522	CDD:465496	12/75 (16%)
		TSP1	535..586	CDD:214559	21/51 (41%)
		ADAMTS_CR_3	<619..693	CDD:437068	16/80 (20%)
		ADAMTS_spacer1	695..808	CDD:461796	9/113 (8%)
		TSP1_ADAMTS	829..884	CDD:465950	15/54 (28%)
		TSP1_ADAMTS	889..946	CDD:465950	16/72 (22%)
		TSP1_ADAMTS	950..999	CDD:465950	13/59 (22%)