DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema5c and adamts17

DIOPT Version :10

Sequence 1:NP_611293.3 Gene:Sema5c / 37066 FlyBaseID:FBgn0284221 Length:1093 Species:Drosophila melanogaster
Sequence 2:XP_004912721.1 Gene:adamts17 / 100380150 XenbaseID:XB-GENE-6460749 Length:1131 Species:Xenopus tropicalis


Alignment Length:907 Identity:187/907 - (20%)
Similarity:270/907 - (29%) Gaps:402/907 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   380 SIGHWLESSRYQLMDEAVQPIGAEPLYHSKLEQFGRLALD----------------IINTKTEQV 428
            ||||..|.|             .|...|.:.|:.|...|.                :..|:|:  
 Frog   284 SIGHHGERS-------------LESFCHWQNEEHGSKYLGNNQVPGAKDDIPVDVAVFMTRTD-- 333

  Fly   429 HVLFVASSGNHIKKLSVKYDG---DGVQTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLAL 490
               |..........:.:.|.|   ...:.|::    |:|.|    ||:|:....:   ||.::.:
 Frog   334 ---FCVHKDEPCDTVGIAYLGGACSAKRKCVL----AEDNG----LNLAFTVAHE---LGHNMGM 384

  Fly   491 T----------------------RIPA----QHCSRHVSQ-------SSCLNSMDPYCGWNELVE 522
            :                      |.|:    ..|||...:       ||||...||...:...:.
 Frog   385 SHDDDHPSCAGRSHIMSGEWVKGRSPSDLSWSTCSRDDLENFLKSKVSSCLLVTDPRSHYAVRLP 449

  Fly   523 RCMPQPQDSSVLQHWHQAPQITCPVL---NAPIDGGWSTWSPWAVCQQHE-----------QPDS 573
            ..:|.       .|:..:.|  |.:|   ||            ..|:..|           :.||
 Frog   450 HKLPG-------MHYSASEQ--CQILFGSNA------------TFCKNMEHLMCAGLWCLVEGDS 493

  Fly   574 NCQ-----------------CRQRSC--NNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPC 619
            :|:                 ||...|  ..|.|||                ..|.|:.||:||.|
 Frog   494 SCKTKLDPPLDGTECGADKWCRAGECVGKTPIPQH----------------VDGDWSAWSSWSMC 542

  Fly   620 SQTCGIAVKIRRRTCGNPRPAFGGRTCVGSEQSEMYCRHLP------------------------ 660
            |:|||...:.|:|.|.||.|..|||:|.|:....|.|.:||                        
 Frog   543 SRTCGTGARFRQRKCDNPPPGPGGRSCRGASVEHMVCENLPCPKGVSSFRDHQCQSHDRSSNKKK 607

  Fly   661 -----------PC-----PVAKPQSV-------DG-GWGPWGEWSEC------SAQCGGGFRMRR 695
                       ||     ||.:...|       || ..||: |...|      ...|.|......
 Frog   608 SPLTAVIIDDRPCELFCTPVGRDTPVLMADRVLDGTPCGPY-EIDLCVHGRCQKIGCDGIIGSSA 671

  Fly   696 RE-----CNDPAPLNGGMECPGCRLDYEE---------------CNMQSCQEVRKLSAWTPWLTV 740
            :|     ||     ..|..|...:.|:..               |.|...:.|.|  .:|.::..
 Frog   672 KEDRCGICN-----GDGKTCKVVKGDFNHTKGMVTSSHCKKVSTCVMTKAKAVAK--CFTCYIEA 729

  Fly   741 TGSGNSSEPHMERRFRFVCRATSPDPSSVRIGLPKEESRNCHAD------------GSCQRQVD- 792
                 :..|...||.|.|    ...|:...:.|.....::.::|            |:..|.|. 
 Frog   730 -----AVIPAGARRIRVV----EDKPAHSFLALKDSIKKSINSDWKIELPGEFQIAGTTIRYVRR 785

  Fly   793 -----------------------HD---------------SADSDA--------------ADWSP 805
                                   ||               |::...              :.|..
 Frog   786 GLWEKISAKGPTKTPLHLMVLLFHDQNYGIHYEYTIPVNQSSEQKPEPEKQPDPMYMWTHSGWEG 850

  Fly   806 CSVSCGGGVQQR---------------------HRGRG-SQSRVCNIHACPAE------EQLSSN 842
            |||.||||.::.                     |..|. .|.|.||:|.|.:.      .|.|| 
 Frog   851 CSVQCGGGERRTVVSCTKIVNKTMVIVNDSLCLHTSRPVPQVRKCNVHPCQSRWVAGTWNQCSS- 914

  Fly   843 SLDN-----------ELEHG------EWGC-------------------W--SEWSACSVTCGLG 869
            :.|.           :|::|      ::.|                   |  ||||.||..||.|
 Frog   915 TCDRGFQLREVTCVFQLQNGTFVNTQDFYCLGPKPATRQICEGQDCLSIWEASEWSKCSSDCGRG 979

  Fly   870 LRRRTRRCLAGH---DRLCQGRALEEQKCEMVPCEDFLGWSAW--SEWSSCSS---DGIRLRHRR 926
            .::|...|....   |...:.||.||       |||:.|...|  .:||.|||   .|::.|..:
 Frog   980 TKKRRISCSNSKGKCDSATRPRAEEE-------CEDYTGCYEWKTGDWSKCSSTCGKGLQSRVVQ 1037

  Fly   927 CLVEQPG--SMECRGAEFEKTA----CVPNECEETQTASTATLPIVIFV-----GLLFTVAC 977
            |:.:..|  ..||  |...|..    |....|.:...|:|.|.|.:..:     |..:||.|
 Frog  1038 CMHKVTGRHGNEC--AIISKPVAYRQCHQEACNDKVNANTITSPRLAALTYKCTGDQWTVYC 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema5cNP_611293.3 Sema_5C 65..496 CDD:200526 27/160 (17%)
PSI 497..546 CDD:396154 12/55 (22%)
TSP1 556..607 CDD:214559 12/80 (15%)
TSP1 610..663 CDD:214559 27/92 (29%)
TSP1 674..725 CDD:214559 14/76 (18%)
TSP1 802..834 CDD:214559 15/53 (28%)
TSP1 853..901 CDD:214559 18/71 (25%)
TSP1 906..953 CDD:214559 15/57 (26%)
adamts17XP_004912721.1 Pep_M12B_propep 22..168 CDD:460254
ZnMc_ADAMTS_like 221..436 CDD:239801 33/180 (18%)
ADAMTS_CR_2 453..520 CDD:465496 14/87 (16%)
TSP1 533..585 CDD:214559 25/51 (49%)
ADAMTS_CR_3 <617..686 CDD:437068 17/74 (23%)
ADAMTS_spacer1 726..822 CDD:461796 13/104 (13%)
TSP1_ADAMTS 848..900 CDD:465950 15/51 (29%)
TSP1_ADAMTS 904..960 CDD:465950 7/56 (13%)
TSP1_ADAMTS 964..1006 CDD:465950 17/48 (35%)
TSP1_ADAMTS 1015..1067 CDD:465950 15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

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