DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema3b

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001120908.1	Gene:	sema3b / 100151737	XenbaseID:	XB-GENE-921561	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	158/564 - (28%)
Similarity:	261/564 - (46%)	Gaps:	80/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKLPKMFSQLWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMST--AKRFYDP 68
            :||.:....|.|||...|:         ||...|         ....:|||||||.  .:.|...
Frog     1 MKLQRSLLSLCLLLYFGLI---------GSNKVT---------PRLKLSYQDLMSLHGLRTFTLE 47

  Fly    69 ETTWYSEMLFDVARNQVIVGARDTLYRMSFDLEPLERAS----WGATPSEIAMCQAKGQSERW-C 128
            .:..|..:..|..|.::.||.::  |.||..|:.:.:..    |.|.......|...|:.... |
Frog    48 RSCCYDALFLDEERGRLFVGGKN--YLMSLSLDNISKQELAIHWPAPVEWREECNWAGKDINVDC 110

  Fly   129 RNYVRVLHSYGENQLYACGTNAFQPSCSW---RQMENLTVTGVD-----SGVVKCPFHPQANSTS 185
            .|||::|..|....|:.|||.||.|:|.:   .|..:.||..:|     .|..:||:.|:..:.:
Frog   111 MNYVKILQPYNRTHLFTCGTGAFHPTCGFVHVGQRTDDTVFKMDLRRMEDGKGRCPYDPKHIAAA 175

  Fly   186 LLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQYNNNWLSGAQFVGSF---EAGH---- 243
            :|..: :|:.|.|||..|.|..|.|:  ...:..|||:|:::.||:..:||..|   |:.:
Frog   176 VLVGD-ELYSGVATDLMGRDFTIFRS--LGRRPPLRTEQHDSRWLNEPKFVKVFWIPESENPDDD 237

  Fly   244 FVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGEY---PYY 305
            .:||..:|:..|.....|..|:|:.::|:||:||...|: :.||:||||||.||:||..   ..:
Frog   238 KIYFFFKETPVEGAGGVKQSYARIGQICRNDLGGQRSLV-NKWTTFLKARLVCSVPGNEIGGDTH 301

  Fly   306 FDEIQGM----TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSDAAWKTV 366
            |||::.:    |......::||.|.||.|...|||:|.|.::.:..||.|||..:|..:..|  |
Frog   302 FDELRDVFLLQTRDRRNPLIYALFSTSSSVFRGSAICVYTMNDVRRAFLGPFAHKEGPNYQW--V 364

  Fly   367 NTNQRSQF----QCGTSSIGHWLESSR------------YQLMDEAVQPIGAEPLY---HSKLEQ 412
            :...:..:    .|.:.:.|.: ||::            :.||...|.|....|::   |..| .
Frog   365 SYQGKVPYPRPGMCPSKTFGSF-ESTKSFPDDVLQFARNHPLMFNPVVPGSGRPVFLRSHGDL-S 427

  Fly   413 FGRLALDIINTKTEQVHVLFVASS-GNHIKKLSV-KYDGDGVQTCLVELWQADDTGTSSLLNMAY 475
            |.:||:|.:.....:..|:|:.:. |:.:|.:|| |.....|:..::|..|. ....|.:..|..
Frog   428 FTQLAVDRVAAADGEYDVMFIGTDVGSVLKVISVPKQSWHHVEQVVLEELQV-FKNASPITTMQI 491

  Fly   476 LKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGWN 518
            ......:|:|:...::::|...|..: .:.:.|..:.||||.|:
Frog   492 SSKRQQIYVGSASGISQLPLHRCGIYGKACAECCLARDPYCAWD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	134/478 (28%)
		PSI	497..546	CDD:279745	7/23 (30%)
		TSP1	556..607	CDD:214559
		TSP1	610..663	CDD:214559
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema3b	NP_001120908.1	Sema_3B	43..514	CDD:200511	134/481 (28%)
		PSI	513..550	CDD:214655	7/23 (30%)
		Ig	575..663	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910