DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema4g

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_002938767.1	Gene:	sema4g / 100038182	XenbaseID:	XB-GENE-856594	Length:	830	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	166/633 - (26%)
Similarity:	282/633 - (44%)	Gaps:	81/633 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YTTKSSVDLLENDSRY-ISYQDLMSTAKRFYDPETTWYSEMLFDVARNQVIVGARDTLYRMSFD- 99
            |:|..|...|:...|. ::|.:::..  |.:....:.||.:|.:..|..:.||||..::.::..
Frog    21 YSTDGSPMGLDATPRITVTYNEILDL--RRFSSRVSNYSTLLLEDERGILYVGARGAIFSLNSTN 83

  Fly   100 -LEPLERA-SWGATPSEIAMCQAKGQSERW-CRNYVRVLHSYGENQLYACGTNAFQPSCSWRQME 161
             .:..::| .|..|..:...|..||::.:. |.|::|:|..:.|..||.|||.||.|.||:....
Frog    84 ISQRYQKAIPWEVTAQKHDECIKKGKNNQTECFNHIRLLLRFNETHLYVCGTYAFSPLCSFIDSR 148

  Fly   162 NLTVTG-VDSGVVKCPFHPQANSTSLLQSNGQLFVGTATDFSGSDVAILRTGVESNKRFLRTKQY 225
            ...::. .:.|..|||:.|......||...|   :.||:.:...::..:|..:  .:|.|:|::.
Frog   149 TFVLSSETEEGKEKCPYDPAKGYVGLLVDGG---LYTASLYEFRNLPDIRRNL--LQRSLKTEES 208

  Fly   226 NNNWLSGAQFVG--------SFEAG--HFVYFLLRESAAEHMSC--GKVIYSRVARVCKNDVGGG 278
            |.:||:..:||.        :.|.|  ..:|:...|...|..|.  |....| ||||||:|: ||
Frog   209 NLHWLNDPEFVSAALVQESMNVEVGDDDKIYYFFNEKVVEENSAFLGSKTAS-VARVCKDDM-GG 271

  Fly   279 GQLLRDNWTSFLKARLNCSLPGEYPYYFDEIQGMTY-----AESESILYATFRTSGSSIFGSAVC 338
            .::|:..|||||||||.|.:|      |.|:....|     :...:|.|..|.....::..||:|
Frog   272 KKILQKKWTSFLKARLVCYMP------FYEVLKSAYTLELGSWDTTIFYGAFILQWKNMEESAIC 330

  Fly   339 AYNLSSINAAFDGPFKQQEHSDAAWK--------------TVNTNQRSQFQCGTSSIGHWLESSR 389
            .|::|.|...|:||:.:.::|...|.              ..|..:.:.|........:.|:..:
Frog   331 RYSISDIQKVFEGPYMEYQYSSRKWSRYEGEVPSPRPGSCITNEFRMNGFNTSQDLPNNVLDFVK 395

  Fly   390 -YQLMDEAVQPIGAEPLYHSKLEQFGRLALDIINTKTEQVH-VLFVASSGNHIKKLSVKYDGDGV 452
             :.||.|.|:|:|.:||...|...:.|:|:|.:....::.: |||:.:....|.|..|    .|.
Frog   396 LHPLMYEKVRPVGEQPLLVKKNIIYTRIAVDRVKALNDEYYDVLFLGTDDGWIHKAVV----IGS 456

  Fly   453 QTCLVELWQADDTGTSSLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSMDPYCGW 517
            ...::|..|.... ...:.|:...|..::||:|....:.:||...||::.|...|:.:.:|||.|
Frog   457 MVHIIEEIQVYKF-PQPVENLVISKKQNALYIGAQSGVLQIPLFGCSQYTSCYDCILARNPYCAW 520

  Fly   518 NELVERCMPQPQDSSVLQHWHQAPQITCPVLNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQRSC 582
            :....|.:...::.:.:....|.....|  ||:..||....    .|.:..:..|...||..||
Frog   521 DGHACRDIIGAKNRTQMTQDMQNGNGGC--LNSTDDGALKK----RVRRVLKGNDVLLQCELRS- 578

  Fly   583 NNPQPQ---HG--------GATCEGISTQVTNCT--QHGGWTEWSAWS 617
            |..:||   :|        |.|..|:...:...|  :|.|  |:|.:|
Frog   579 NLARPQWYVNGTDKLYDSEGHTRLGVDGLLITDTLPEHSG--EYSCYS 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	125/468 (27%)
		PSI	497..546	CDD:279745	10/48 (21%)
		TSP1	556..607	CDD:214559	14/63 (22%)
		TSP1	610..663	CDD:214559	3/8 (38%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema4g	XP_002938767.1	Sema	47..499	CDD:417757	126/469 (27%)
		PSI	500..>527	CDD:214655	8/26 (31%)
		Ig_Sema4B_like	557..643	CDD:409456	19/75 (25%)
		Ig strand B	570..574	CDD:409456	0/3 (0%)
		Ig strand C	582..586	CDD:409456	2/3 (67%)
		Ig strand E	605..609	CDD:409456	0/3 (0%)
		Ig strand F	619..624	CDD:409456	2/4 (50%)
		Ig strand G	636..639	CDD:409456
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910