DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5c and sema3bl

DIOPT Version :9

Sequence 1:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001116184.1	Gene:	sema3bl / 100004611	ZFINID:	ZDB-GENE-030131-2956	Length:	771	Species:	Danio rerio

Alignment Length:	732	Identity:	176/732 - (24%)
Similarity:	285/732 - (38%)	Gaps:	179/732 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYDPETTWY--------- 73
            |.:|.|:.|..|..|     .||.:|..|.     ::::||:.|.:      |:.:
Zfish     3 LPVLVLVALVLPLSS-----CTKVNVPRLR-----LTHKDLLDTNR------TSVFNGLHGDLHL 51

  Fly    74 SEMLFDVARNQVIVGARDTLYRMSFD-LEPLERASWGATPSEIAMCQAKGQS-ERWCRNYVRVLH 136
            |.:..|...:::.:|.:|.||.:..| ....:...|.:.|.....|..||:. |..|.|:||:|.
Zfish    52 SAVFLDEYHDRLFLGGKDVLYSLRLDHTHDAKEIHWPSLPGNREDCILKGKDPEMECANFVRLLQ 116

  Fly   137 SYGENQLYACGTNAFQPSCSW-------RQMENLTVTGVDSGVVKCPFHPQANSTSLLQSNGQLF 194
            .:....|.||||.||||.|::       ..:.:|..|.|.:|..:||..|:....|.. :.|:|:
Zfish   117 PFNRTHLLACGTGAFQPVCAYVNVGHRGEHVFSLDQTTVQNGRGRCPHDPKLPFASTF-TGGELY 180

  Fly   195 VGTATDFSGSDVAI---------LRTGVESNKRFLRTKQYNNNWLSGAQFVGSFEAGHF------ 244
            .|...||.|.|..|         :||  |:::|.|...:              |.|.|.
Zfish   181 TGLTADFLGRDSVISRGFGTRSPMRT--ETDQRILHEPR--------------FVAAHLIPDSAD 229

  Fly   245 -----VYFLLRESA---AEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKARLNCSLPGE 301
                 :||...|.|   ||....| .|::|:.|:|.||| ||.::|.:.|::|:||||.||:||.
Zfish   230 RDDDKIYFFFTERATETAERDDDG-AIHTRIGRLCANDV-GGQRVLVNKWSTFIKARLVCSVPGP 292

  Fly   302 Y--PYYFDEIQGM----TYAESESILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQEHSD 360
            :  ..:|.:::.:    |..|:...:||.|.|..:...|.|||.|:::.|..||:|||..:|..|
Zfish   293 HGIQTHFHQLEDVFLLRTKDETNPEIYAIFSTISNVFQGYAVCVYSMADIREAFNGPFAHKEGPD 357

  Fly   361 AAW----------------KTVNTNQRSQFQCGTSSIGHWLESSR-YQLMDEAVQPIGAEPLYHS 408
            ..|                ..:.......|:.........|:.:| :.||...|.|...:||...
Zfish   358 YQWGPYEGRVPYPRPGVCPSKITAQPGRAFRSTLEFPDTVLQFARTHPLMWRPVYPSHRQPLLLR 422

  Fly   409 KLEQFGRLALDIINTKTEQVH--VLFVASSGNHIKKLSVKYDGD---GVQTCLVELWQADDTGTS 468
            ....:....:.:..|:.|..:  |:|:.:....:.|:.|...|:   |.:..|.|: |.....|
Zfish   423 TGAPYRLTHITVDRTQAEDGYYDVMFIGTDIGTVLKVIVLGKGNSLAGEEITLEEM-QVFKVPT- 485

  Fly   469 SLLNMAYLKVSDSLYLGTDLALTRIPAQHCSRH-VSQSSCLNSMDPYCGWN-ELVERCMP----- 526
            .:.:|.......:|::|:..|:.::|...||.: .:.:.|..:.||||.|: :...|.:|
Zfish   486 PITSMDISVKRQTLFVGSQTAVVQVPLHRCSMYGKACAECCLARDPYCAWDGQTCTRYLPNTKRR 550

  Fly   527 -QPQDSSVLQHWHQAPQITCPVLNAPIDG-------------GWSTW------SPWAVCQQHEQP 571
             :.||..     |..|.:.|...|..::.             ..||:      ||.|....|.|.
Zfish   551 YRRQDIK-----HANPAVQCMDQNLSVEDVDLSEERVVYGTENNSTFLECVPRSPQATVTWHIQR 610

  Fly   572 DSNC-----------------------------QCRQRSCNNPQPQHG-GATCEGISTQVTNCTQ 606
            |...                             .||.|       :|| ..|.......|.|...
Zfish   611 DDYLGEVVFDERIIKTDDGLLFRRVLRQDEGIYVCRSR-------EHGFTQTLSRFWLDVLNADT 668

  Fly   607 HGGW----TEWSAWSPC 619
            ....    :::..||||
Zfish   669 LSDLLSRDSKYKVWSPC 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	127/499 (25%)
		PSI	497..546	CDD:279745	14/56 (25%)
		TSP1	556..607	CDD:214559	16/86 (19%)
		TSP1	610..663	CDD:214559	4/14 (29%)
		TSP1	674..725	CDD:214559
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
sema3bl	NP_001116184.1	Sema_3G	42..515	CDD:200516	126/493 (26%)
		PSI	514..>550	CDD:214655	10/35 (29%)
		Ig_Semaphorin_classIII	579..664	CDD:143279	14/91 (15%)
		IG_like	581..663	CDD:214653	14/88 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810