DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stau and Stau1

DIOPT Version :9

Sequence 1:	NP_476751.1	Gene:	stau / 37065	FlyBaseID:	FBgn0003520	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_445888.1	Gene:	Stau1 / 84496	RGDID:	621778	Length:	495	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	178/581 - (30%)
Similarity:	259/581 - (44%)	Gaps:	143/581 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 QPMHPH------FFHGPGQRPFPPKFPSRFALPPPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQ 531
            :|:.||      :.:|.....:||::...|.:||.|                   .::.|.||.|
  Rat     3 KPVDPHSRMQSTYSYGMRGGAYPPRYFYPFPVPPLL-------------------YQVELSVGGQ 48

  Fly   532 KFVGIGRTLQQAKHDAAARALQVLKTQAISASEEALE----DSMDEGDKKSPISQVHEIGIKRNM 592
            :|.|.|:.....||||.||||:.|:::.:   .|.||    :|.:|...||.||||.||.:|||:
  Rat    49 QFNGKGKMRPPVKHDATARALRTLQSEPL---PERLEVNGRESEEENLNKSEISQVFEIALKRNL 110

  Fly   593 TVHF------KVLREEGPAHMKNFITACIVGSIVTEGEGNGKKVSKKRAAEKMLVELQKLPPLTP 651
            .|:|      :|.||.||.|||||:|...||..|.||||..||:|||.||..:|.:|::|||| |
  Rat   111 PVNFESFPLTQVARESGPPHMKNFVTRVSVGEFVGEGEGKSKKISKKNAARAVLEQLRRLPPL-P 174

  Fly   652 TKQTPLKRIKVKTPGKSGAAAREGSVVSGTDGPTQTGKPERRKRLNPPKDKLIDMDDADNPITKL 716
            ..:....|||.|:                        :|..:.:..|      |.....|||::|
  Rat   175 AVERVKPRIKKKS------------------------QPTCKLQTAP------DYGQGMNPISRL 209

  Fly   717 IQLQQTRKEKEPIFELIAKNGNETARRREFVMEVSASGSTARGTGNSKKLAKRNAAQALFELL-- 779
            .|:||.:|||||.:.|:.:.|  ..|||||||:|.....||.|.|.:||:||||||:.:.|:|
  Rat   210 AQIQQAKKEKEPEYMLLTERG--LPRRREFVMQVKVGHHTAEGAGTNKKVAKRNAAENMLEILGF 272

  Fly   780 EAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAEGKVPMVATPVGPMPGILILRQNKKPAKKR 844
            :..|..|......|||                          .|||            |||...|
  Rat   273 KVPQAQPAKPALKSEE--------------------------KTPV------------KKPGDGR 299

  Fly   845 DQIVIVKSNVESKEEEANKEVAVAAEENSNNSANSG-----DSSNSSSGDSQA--TEAASESALN 902
             ::...:.:...:...:|||........|:....:|     .....:.|.||.  |:..:.:|.|
  Rat   300 -KVTFFEPSPGDENGTSNKEDEFRMPYLSHQQLPAGILPMVPEVAQAVGVSQGHHTKDFARAAPN 363

  Fly   903 TSTGSNTS---------GVSSNSSNVGANTDGNNHAESKNNTESSSNSTSNTQSAGVHMKEQLLY 958
            .:..:.|:         |.|..:..:..:...:.|......|..|               |||.|
  Rat   364 PAKATVTAMIARELLYGGTSPTAETILKSNISSGHVPHGPRTRPS---------------EQLYY 413

  Fly   959 LSKLLDFEVNFSDYPKGNHNEFLTIVTLSTHPPQICHGVGKSSEESQNDAASNALKILSKL 1019
            ||:...|:|.:.|:||.|.||.::::..|:.||.:.||:||..|...:.||.|.||:||:|
  Rat   414 LSRAQGFQVEYKDFPKNNKNECVSLINCSSQPPLVSHGIGKDVESCHDMAALNILKLLSEL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stau	NP_476751.1	DSRM	312..375	CDD:214634
		DSRM	<529..555	CDD:294045	13/25 (52%)
		DSRM	579..644	CDD:214634	37/70 (53%)
		DSRM	712..780	CDD:214634	35/69 (51%)
		Staufen_C	<953..1020	CDD:293091	30/67 (45%)
Stau1	NP_445888.1	DSRM_SF	1..70	CDD:412133	24/85 (28%)
		DSRM_SF	95..167	CDD:412133	39/71 (55%)
		DSRM_STAU1_rpt4	194..279	CDD:380714	39/92 (42%)
		Staufen_C	366..475	CDD:374568	36/124 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9205
eggNOG	1	0.900	-	-		E1_KOG3732
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355202at33208
OrthoFinder	1	1.000	-	-		FOG0002435
OrthoInspector	1	1.000	-	-		otm46102
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46054
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880