DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stau and TARBP2

DIOPT Version :9

Sequence 1:NP_476751.1 Gene:stau / 37065 FlyBaseID:FBgn0003520 Length:1026 Species:Drosophila melanogaster
Sequence 2:NP_599150.1 Gene:TARBP2 / 6895 HGNCID:11569 Length:366 Species:Homo sapiens


Alignment Length:468 Identity:106/468 - (22%)
Similarity:157/468 - (33%) Gaps:143/468 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   566 ALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGEGNGKKV 630
            ::|..:.....|:|||.:.|.|.:...|..:.:|:.||.||..||.....||.....|:|..||.
Human    18 SIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKA 82

  Fly   631 SKKRAAEKMLVELQKLPPLTPTKQ-----TPL-----KRIKVKTPGKSGAAAREGSVVSGTDGPT 685
            :|.:|||..|..|:....|.|..:     :||     :.|.|.|  .:.||....|||.....|.
Human    83 AKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFT--AAAAATPVPSVVLTRSPPM 145

  Fly   686 QTGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEV 750
            :         |.||   :.......||:..|.:|...:..:.|.:.:..::|  .|.|:||.|..
Human   146 E---------LQPP---VSPQQSECNPVGALQELVVQKGWRLPEYTVTQESG--PAHRKEFTMTC 196

  Fly   751 SASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAE 815
            ........|:|.||||||||||..                                         
Human   197 RVERFIEIGSGTSKKLAKRNAAAK----------------------------------------- 220

  Fly   816 GKVPMVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKEVAVAAEENSNNSANSG 880
                            ::||.:..|...||                ..||             ..
Human   221 ----------------MLLRVHTVPLDARD----------------GNEV-------------EP 240

  Fly   881 DSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSSNSTSNT 945
            |..:.|.|                .||...|:.:...  |...|...::..:......|.|..:.
Human   241 DDDHFSIG----------------VGSRLDGLRNRGP--GCTWDSLRNSVGEKILSLRSCSLGSL 287

  Fly   946 QSAGVHMKEQLLYLSKLLDFEVNFSDYPKGNHNEFLT-------IVTLSTHPPQICHGVGKSSEE 1003
            .:.|......|..||:...|.|::.|.      |.|:       :|.|||.|..:|||...:.|.
Human   288 GALGPACCRVLSELSEEQAFHVSYLDI------EELSLSGLCQCLVELSTQPATVCHGSATTREA 346

  Fly  1004 SQNDAASNALKIL 1016
            ::.:||..||:.|
Human   347 ARGEAARRALQYL 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stauNP_476751.1 DSRM 312..375 CDD:214634
DSRM <529..555 CDD:294045
DSRM 579..644 CDD:214634 24/64 (38%)
DSRM 712..780 CDD:214634 22/67 (33%)
Staufen_C <953..1020 CDD:293091 22/71 (31%)
TARBP2NP_599150.1 Sufficient for interaction with PRKRA 22..105 28/82 (34%)
DSRM_TARBP2_rpt1 27..98 CDD:380719 26/70 (37%)
Sufficient for interaction with PRKRA 152..234 26/140 (19%)
DSRM_TARBP2_rpt2 159..225 CDD:380681 24/124 (19%)
Sufficient for interaction with DICER1 228..366 38/185 (21%)
Sufficient for interaction with PRKRA 287..366 23/79 (29%)
DSRM_TARBP2_rpt3 292..363 CDD:380722 22/74 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3732
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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