DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stau and stau1

DIOPT Version :9

Sequence 1:	NP_476751.1	Gene:	stau / 37065	FlyBaseID:	FBgn0003520	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_991124.2	Gene:	stau1 / 334440	ZFINID:	ZDB-GENE-030131-6372	Length:	702	Species:	Danio rerio

Alignment Length:	755	Identity:	250/755 - (33%)
Similarity:	345/755 - (45%)	Gaps:	193/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 TSSSGRGGKDKTPMCLVNELARYNKITHQYRLTEERGPAHCKTFTVTLMLGDEEYSADGFKIKKA 364
            |.|:....|:||||||||||||||||..:|:|..|.||||.|.|:|.|.|||:.:.|:|..||||
Zfish    63 TVSNMANPKEKTPMCLVNELARYNKIQPEYKLLSEEGPAHSKIFSVRLTLGDQHWDAEGTSIKKA 127

  Fly   365 QHLAASKAIEETMY---KHPPPKIRRSEEGGPMR---THITPTVELNALAMKLGQRTFYLLDPTQ 423
            ||.|||.|:.:|..   .|..|:......||..:   .::|.|||||||.||||::..|
Zfish   128 QHSAASSALAQTTLPKPSHRSPRHPGKSPGGIYKGSEYNVTHTVELNALCMKLGKKPIY------ 186

  Fly   424 IPPTDSIVPPEFAGGHLLTAPGPGMPQPPPPPAYALRQRLGNGFVPIPSQPMHPHFFHGPGQRPF 488
             .|.|:......|..:.:.||.|          ||...:               |:::     ||
Zfish   187 -KPIDAYQGMRPAFNYNIRAPSP----------YARSMQ---------------HYYY-----PF 220

  Fly   489 PPKFPSRFALPPPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQKFVGIGRTLQQAKHDAAARALQ 553
                       ||:|..::|               :.|.:|.|:|.|.|||.|.|||||||:|::
Zfish   221 -----------PPVGPVLYH---------------MELSIGGQQFHGKGRTRQAAKHDAAAKAIK 259

  Fly   554 VLKTQAI-SASEEALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVG 617
            .|:.:.| ....|..::...|...||.||||.||.:||||.|.|:||:|.|..|||:|:...:||
Zfish   260 YLQKEPILQQITEMTDEPAQENLNKSEISQVFEIALKRNMPVDFEVLKEAGAPHMKSFVVRVVVG 324

  Fly   618 SIVTEGEGNGKKVSKKRAAEKMLVELQKLPPLTPTKQTPLKRIKVKTPGKSGAAAREGSVVSGTD 682
            ....||||..||::||:||..:|.||::||.|..|.:.|| |||.|:.          |::.
Zfish   325 EFAGEGEGKSKKIAKKQAAIAVLEELRRLPQLPATDKIPL-RIKKKSK----------SIIK--- 375

  Fly   683 GPTQTGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFV 747
              .|| .||..:.:              |||::|.|:||.:|||||.:.|:.:.|  ..||||||
Zfish   376 --LQT-SPEYGQGM--------------NPISRLAQIQQAKKEKEPEYTLVTERG--LPRRREFV 421

  Fly   748 MEVSASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEA 812
            |:||.:|..|.|.|.|||:||||||:.:.|||..
Zfish   422 MQVSVAGQNAEGMGPSKKVAKRNAAEKMLELLGF------------------------------- 455

  Fly   813 TAEGKVPMVATPVGPMPGILILRQNKKPAKK----RDQIVIVKSNVE------SKEEEAN----- 862
                |||.   |..|.|.  :....|.||||    |........::|      ||||:..
Zfish   456 ----KVPQ---PQPPKPA--LKTDEKPPAKKLGDGRKVTFFEPGSMEKAGLVVSKEEDFRLPFLS 511

  Fly   863 ------------KEVAVAAEENSNNSANS-GDSSNSSSGDSQATEAASESALNTSTGSNTSGVSS 914
                        .|||.|...|....|.. |.::..:..::..|...:...|...|.....|:..
Zfish   512 HQQLPAGILPMVPEVAQAVGANQGPHAKDYGRTAAPNPANATVTAMIANELLYAGTSPTAEGILK 576

  Fly   915 NSSNVGANTDGNNHAESKNNTESSSNSTSNTQSAGVHMKEQLLYLSKLLDFEVNFSDYPKGNHNE 979
            .::::.....|.....|                      |||.||:.:...:|.:.|:||.|.||
Zfish   577 TNNSLAHRPQGPLTRPS----------------------EQLSYLANVQGLQVEYKDFPKNNKNE 619

  Fly   980 FLTIVTLSTHPPQICHGVGKSSEESQNDAASNALKILSKL 1019
            |::::..|:.||.|.||:||..|...:.||.|.||:||:|
Zfish   620 FVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSEL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stau	NP_476751.1	DSRM	312..375	CDD:214634	40/62 (65%)
		DSRM	<529..555	CDD:294045	16/25 (64%)
		DSRM	579..644	CDD:214634	34/64 (53%)
		DSRM	712..780	CDD:214634	37/67 (55%)
		Staufen_C	<953..1020	CDD:293091	30/67 (45%)
stau1	NP_991124.2	DSRM	75..138	CDD:214634	40/62 (65%)
		DSRM	287..350	CDD:214634	33/62 (53%)
		DSRM	387..453	CDD:238007	37/67 (55%)
		Staufen_C	551..660	CDD:293091	36/131 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8139
eggNOG	1	0.900	-	-		E1_KOG3732
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355202at33208
OrthoFinder	1	1.000	-	-		FOG0002435
OrthoInspector	1	1.000	-	-		otm25904
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46054
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4772
SonicParanoid	1	1.000	-	-		X1848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960