DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stau and Stau2

DIOPT Version :9

Sequence 1:	NP_476751.1	Gene:	stau / 37065	FlyBaseID:	FBgn0003520	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_079579.2	Gene:	Stau2 / 29819	MGIID:	1352508	Length:	570	Species:	Mus musculus

Alignment Length:	677	Identity:	218/677 - (32%)
Similarity:	291/677 - (42%)	Gaps:	181/677 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 KDKTPMCLVNELARYNKITHQYRLTEERGPAHCKTFTVTLMLGDEEYSADGFKIKKAQHLAASKA 372
            |:|||:||||||||::.|..||:|..|.||||.|.|:|.|.||::.:.::|..|||||...|:||
Mouse     5 KEKTPVCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKA 69

  Fly   373 IEETMYKHP---PPKIRRSEEGGPMRTHITPTVELNALAMKLGQRTFYLLDPTQIPPTDSIVPPE 434
            :.|:....|   |||...:...|    .||||||||.||||.|:...|       .|.|
Mouse    70 LTESTLPKPVQKPPKSNVNNNPG----SITPTVELNGLAMKRGEPAIY-------RPLD------ 117

  Fly   435 FAGGHLLTAPGPGMPQPPPPPAYALRQRLGNGFVPIPSQPMHPHFFHGPGQRPFPPKFPSRFALP 499
                            |.|.|.|    |....|..:.:|..|         .|.|..|
Mouse   118 ----------------PKPFPNY----RANYNFRGMYNQRYH---------CPMPKIF------- 146

  Fly   500 PPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQKFVGIGRTLQQAKHDAAARALQVLKTQAI---- 560
                                   .:.|.||..:|.|.|:|.|.|:|:||.:|||.|:.:.|
Mouse   147 -----------------------YVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKS 188

  Fly   561 -SASEEALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGE 624
             ...|...|...|:...||.||.|.||.:||||.|.|:|::|.||.|||:|:|...||....|||
Mouse   189 PQNGESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGE 253

  Fly   625 GNGKKVSKKRAAEKMLVELQKLPPLTPTKQTPLKRIKVKTPGKSGAAAREGSVVSGTDGPTQTGK 689
            ||.||:||||||..:|.||:||||| |..:.|....|          .|..::|..  ||
Mouse   254 GNSKKLSKKRAATTVLQELKKLPPL-PVVEKPKLFFK----------KRPKTIVKA--GP----- 300

  Fly   690 PERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEVSASG 754
                           |.....|||::|.|:||.||||||.:.|:::.|  ..|||||||:|....
Mouse   301 ---------------DYGQGMNPISRLAQIQQARKEKEPDYILLSERG--MPRRREFVMQVKVGN 348

  Fly   755 STARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAEGKVP 819
            ..|.|||.:||:||:|||:|:.             .|...:.|||      ....::.|.|.|
Mouse   349 EVATGTGPNKKIAKKNAAEAML-------------LQLGYKASTS------LQDPLDKTGENK-- 392

  Fly   820 MVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKEVAVAA------EENSNNSAN 878
               ...||.||.      .:|.....:.::..|....:|.||::....:.      .....|..:
Mouse   393 ---GWSGPKPGF------PEPTNNTPKGILHLSPDVYQEMEASRHRVTSGTTLSYLSPKDMNQPS 448

  Fly   879 SGDSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSSNSTS 943
            |...|.|.|..|.|| .|.|..:|        |.|..:..:|.               ..|:.||
Mouse   449 SSFFSVSPSSTSSAT-VARELLMN--------GTSPTAEAIGL---------------KGSSPTS 489

  Fly   944 NTQSAGVHMKEQLLYLSKLLDFEVNFS 970
            ...|  |...:||.||:::..|:...|
Mouse   490 PCSS--VQPSKQLEYLARIQGFQAALS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stau	NP_476751.1	DSRM	312..375	CDD:214634	33/62 (53%)
		DSRM	<529..555	CDD:294045	13/25 (52%)
		DSRM	579..644	CDD:214634	37/64 (58%)
		DSRM	712..780	CDD:214634	34/67 (51%)
		Staufen_C	<953..1020	CDD:293091	6/18 (33%)
Stau2	NP_079579.2	DSRM_STAU2_rpt1	3..70	CDD:380709	35/64 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..94		6/26 (23%)
		DSRM_STAU2_rpt2	98..179	CDD:380711	38/152 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..203		5/24 (21%)
		DSRM_STAU2_rpt3	206..272	CDD:380713	38/65 (58%)
		Nuclear localization signal 1	273..291		8/28 (29%)
		DSRM_STAU2_rpt4	304..389	CDD:380715	39/105 (37%)
		Nuclear localization signal 2. /evidence=ECO:0000250	373..412		11/55 (20%)
		Required for dendritic transport. /evidence=ECO:0000250	381..570		37/171 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..413		8/42 (19%)
		Staufen_C	465..523	CDD:374568	17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8845
eggNOG	1	0.900	-	-		E1_KOG3732
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6775
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355202at33208
OrthoFinder	1	1.000	-	-		FOG0002435
OrthoInspector	1	1.000	-	-		otm44010
orthoMCL	1	0.900	-	-		OOG6_108158
Panther	1	1.100	-	-	LDO	PTHR46054
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4772
SonicParanoid	1	1.000	-	-		X1848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760