Protein Alignment stau and STAU2

DIOPT Version :10

• Sequence 1: NP_476751.1
• Gene: stau / 37065
• FlyBaseID: FBgn0003520
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_001157852.1
• Gene: STAU2 / 27067
• HGNCID: 11371
• Length: 570
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 214/680 - (31%)
• Similarity: 299/680 - (43%)
• Gaps: 187/680 - (27%)

  Fly   308 KDKTPMCLVNELARYNKITHQYRLTEERGPAHCKTFTVTLMLGDEEYSADGFKIKKAQHLAASKA 372
            |:||.|||||||||:|::..||:|..||||||.|.|:|.|.||::.:.::|..|||||...|:||
Human     5 KEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKA 69

  Fly   373 IEETMYKHP---PPKIRRSEEGGPMRTHITPTVELNALAMKLGQRTFYLLDPTQIPPTDSIVPPE 434
            :.|:....|   |||...:...|    .||||||||.||||.|:...|       .|.|
Human    70 LTESTLPKPVQKPPKSNVNNNPG----SITPTVELNGLAMKRGEPAIY-------RPLD------ 117

  Fly   435 FAGGHLLTAPGPGMPQPPPPPAYALRQRLGNGFVPIPSQPMHPHFFHGPGQRPFPPKFPSRFALP 499
                            |.|.|.|    |....|     :.|:...:|.|..:.|
Human   118 ----------------PKPFPNY----RANYNF-----RGMYNQRYHCPVPKIF----------- 146

  Fly   500 PPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQKFVGIGRTLQQAKHDAAARALQVLKTQAI---- 560
                                   .:.|.||..:|.|.|:|.|.|:|:||.:|||.|:.:.|
Human   147 -----------------------YVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPERS 188

  Fly   561 SASEEALEDSMDEGD-KKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGE 624
            ..:.|:.:|..|:.| .||.||.|.||.:||||.|.|:|::|.||.|||:|:|...||....|||
Human   189 PQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGE 253

  Fly   625 GNGKKVSKKRAAEKMLVELQKLPPLTPTKQTP---LKRIKVKTPGKSGAAAREGSVVSGTDGPTQ 686
            ||.||:||||||..:|.||:||||| |..:.|   .|: :.||..|:|....:|.
Human   254 GNSKKLSKKRAATTVLQELKKLPPL-PVVEKPKLFFKK-RPKTIVKAGPEYGQGM---------- 306

  Fly   687 TGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEVS 751
                                    |||::|.|:||.:|||||.:.|:::.|  ..|||||||:|.
Human   307 ------------------------NPISRLAQIQQAKKEKEPDYVLLSERG--MPRRREFVMQVK 345

  Fly   752 ASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAEG 816
            .....|.|||.:||:||:|||:|:  ||:......||.....|:...:...|
Human   346 VGNEVATGTGPNKKIAKKNAAEAM--LLQLGYKASTNLQDQLEKTGENKGWS------------- 395

  Fly   817 KVPMVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKEVAVAA------EENSNN 875
                     ||.||.      .:|.....:.::..|....:|.||::...::.      .....|
Human   396 ---------GPKPGF------PEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMN 445

  Fly   876 SANSGDSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSSN 940
            ..:|...|.|.:.:|.|| .|.|..:|        |.||.:..:|.                 ..
Human   446 QPSSSFFSISPTSNSSAT-IARELLMN--------GTSSTAEAIGL-----------------KG 484

  Fly   941 STSNTQSAGVHMKEQLLYLSKLLDFEVNFS 970
            |:.....:.|...:||.||:::..|:...|
Human   485 SSPTPPCSPVQPSKQLEYLARIQGFQAALS 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stau	NP_476751.1	DSRM_STAU_rpt1	311..373	CDD:380686	34/61 (56%)
		DSRM_STAU_rpt2	473..553	CDD:380687	17/79 (22%)
		DSRM_STAU_rpt3	579..643	CDD:380688	36/63 (57%)
		DSRM_STAU_rpt4	711..780	CDD:380689	35/68 (51%)
		DSRM_STAU_rpt5	952..1019	CDD:380690	6/19 (32%)
STAU2	NP_001157852.1	DSRM_SF	3..70	CDD:444671	36/64 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..94		6/26 (23%)
		DSRM_STAU2_rpt2	98..179	CDD:380711	37/152 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..203		4/21 (19%)
		DSRM_STAU2_rpt3	206..272	CDD:380713	38/65 (58%)
		Nuclear localization signal 1. /evidence=ECO:0000250	273..291		8/19 (42%)
		DSRM_STAU2_rpt4	304..389	CDD:380715	40/122 (33%)
		Nuclear localization signal 2. /evidence=ECO:0000250	373..412		9/66 (14%)
		Required for dendritic transport. /evidence=ECO:0000250	381..570		33/188 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..409		6/49 (12%)
		Staufen_C	461..523	CDD:465131	17/80 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..570