DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stau and Stau2

DIOPT Version :9

Sequence 1:	NP_476751.1	Gene:	stau / 37065	FlyBaseID:	FBgn0003520	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001007150.2	Gene:	Stau2 / 171500	RGDID:	621479	Length:	571	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	217/681 - (31%)
Similarity:	296/681 - (43%)	Gaps:	188/681 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 KDKTPMCLVNELARYNKITHQYRLTEERGPAHCKTFTVTLMLGDEEYSADGFKIKKAQHLAASKA 372
            |:||||||||||||::.|..||:|..|.||||.|.|:|.|.||::.:.::|..|||||...|:||
  Rat     5 KEKTPMCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKA 69

  Fly   373 IEETMYKHP---PPKIRRSEEGGPMRTHITPTVELNALAMKLGQRTFYLLDPTQIPPTDSIVPPE 434
            :.|:....|   |||...:...|    .||||||||.||||.|:...|       .|.|
  Rat    70 LTESTLPKPVQKPPKSNVNNNPG----SITPTVELNGLAMKRGEPAIY-------RPLD------ 117

  Fly   435 FAGGHLLTAPGPGMPQPPPPPAYALRQRLGNGFVPIPSQPMHPHFFHGPGQRPFPPKFPSRFALP 499
                            |.|.|.|    |....|..:.:|..|         .|.|..|
  Rat   118 ----------------PKPFPNY----RANYNFRGMYNQRYH---------CPMPKIF------- 146

  Fly   500 PPLGAHVHHGPNGPFPSVPTPPSKITLFVGKQKFVGIGRTLQQAKHDAAARALQVLKTQAI---- 560
                                   .:.|.||..:|.|.|:|.|.|:|:||.:|||.|:.:.|
  Rat   147 -----------------------YVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKS 188

  Fly   561 -SASEEALEDSMDEGDKKSPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVGSIVTEGE 624
             ...|...|...|:...||.||.|.||.:||||.|.|:|::|.||.|||:|:|...||....|||
  Rat   189 PQNGESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGE 253

  Fly   625 GNGKKVSKKRAAEKMLVELQKLPPLTPTKQTP---LKRIKVKTPGKSGAAAREGSVVSGTDGPTQ 686
            ||.||:||||||..:|.||:||||| |..:.|   .|: :.||..|:|....:|.
  Rat   254 GNSKKLSKKRAATTVLQELKKLPPL-PVIEKPKLFFKK-RPKTIIKAGPEYGQGM---------- 306

  Fly   687 TGKPERRKRLNPPKDKLIDMDDADNPITKLIQLQQTRKEKEPIFELIAKNGNETARRREFVMEVS 751
                                    |||::|.|:||.||||||.:.|:::.|  ..|||||||:|.
  Rat   307 ------------------------NPISRLAQIQQARKEKEPDYVLLSERG--MPRRREFVMQVK 345

  Fly   752 ASGSTARGTGNSKKLAKRNAAQALFELLEAVQVTPTNETQSSEECSTSATMSAVTAPAVEATAEG 816
            .....|.|||.:||:||:|||:|:.             .|...:.|||      ....::.|.|.
  Rat   346 VGNEVATGTGPNKKIAKKNAAEAML-------------LQLGYKASTS------LQDQLDKTGEN 391

  Fly   817 KVPMVATPVGPMPGILILRQNKKPAKKRDQIVIVKSNVESKEEEANKE-------VAVAAEENSN 874
            |     ...||.||.      .:||....:.::..|....:|.||::.       :...:.::.|
  Rat   392 K-----GWSGPKPGF------PEPANNTPKGILHLSPDVYQEMEASRHRVTSGTTLGYLSPKDMN 445

  Fly   875 NSANSGDSSNSSSGDSQATEAASESALNTSTGSNTSGVSSNSSNVGANTDGNNHAESKNNTESSS 939
            ..::|..|..|.|..|.| .||.|..:|        |.|..:..:|.                 .
  Rat   446 QPSSSFFSVESPSPTSSA-PAARELLMN--------GTSPAAEAIGL-----------------K 484

  Fly   940 NSTSNTQSAGVHMKEQLLYLSKLLDFEVNFS 970
            .|:.....:.|...:||.||:::..|:...|
  Rat   485 GSSPTPPCSSVQPSKQLEYLARIQGFQAALS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stau	NP_476751.1	DSRM	312..375	CDD:214634	34/62 (55%)
		DSRM	<529..555	CDD:294045	13/25 (52%)
		DSRM	579..644	CDD:214634	37/64 (58%)
		DSRM	712..780	CDD:214634	34/67 (51%)
		Staufen_C	<953..1020	CDD:293091	6/18 (33%)
Stau2	NP_001007150.2	DSRM_SF	3..70	CDD:412133	36/64 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..94		6/26 (23%)
		DSRM_STAU2_rpt2	98..179	CDD:380711	38/152 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..203		5/24 (21%)
		DSRM_STAU2_rpt3	206..272	CDD:380713	38/65 (58%)
		Nuclear localization signal 1	273..317		18/79 (23%)
		DSRM_STAU2_rpt4	304..389	CDD:380715	40/139 (29%)
		Nuclear localization signal 2	373..412		12/55 (22%)
		Required for dendritic transport	381..571		35/172 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..413		9/41 (22%)
		Staufen_C	457..524	CDD:374568	18/85 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9002
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355202at33208
OrthoFinder	1	1.000	-	-		FOG0002435
OrthoInspector	1	1.000	-	-		otm46102
orthoMCL	1	0.900	-	-		OOG6_108158
Panther	1	1.100	-	-	O	PTHR46054
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920