Protein Alignment CG5098 and kmt2bb

DIOPT Version :10

• Sequence 1: NP_001261066.1
• Gene: CG5098 / 37063
• FlyBaseID: FBgn0034300
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_002664717.2
• Gene: kmt2bb / 566825
• ZFINID: ZDB-GENE-080521-1
• Length: 3772
• Species: Danio rerio
• Alignment Length: 1214
• Identity: 242/1214 - (19%)
• Similarity: 401/1214 - (33%)
• Gaps: 366/1214 - (30%)

  Fly   178 SLLQSSRQNQ----GAPSGNLS-NGG---DCESLLP-PPPPTS----VSGNTNHTGSNSSSNSGS 229
            |.|:|.::.|    |.....:| |||   .|..|.| ...|.|    :..:....|....|:|||
Zfish    37 SRLRSEKRWQLGRCGTDLDEISANGGPRPTCLVLAPNEDQPLSRLLGLEASYKRLGEAGYSSSGS 101

  Fly   230 NNHIASPHYMQSRDENFKLTQLKRSFEPDLSGKNPQKEKDFGYPSASSASKLPTHNVQQQHANKK 294
            ..        .|..:.|::....||. |..:|:||.|.   |..|..|:.:     ::|:.|
Zfish   102 EE--------GSEFKGFEVQNENRSI-PVRAGRNPCKR---GRVSVKSSKR-----IRQRLA--- 146

  Fly   295 PSPLRNYHQQQQPPYNLTPKYNGPQTPPTPQSPL--AANPHQMLSPTMDYNQLHLHHQLNSSS-- 355
                                        .|.|||  :...|...:.:....|||.......:|
Zfish   147 ----------------------------LPVSPLVESTGSHDPQNDSGTVQQLHSQESQKDTSVD 183

  Fly   356 -GGSYQHMQQDQTQSQSHPQHLHYHNQHATSQTAPPPLL-----PPLLTSGQFHAQP-------- 406
             ||.......|...:...|......::...:||.|...:     ..::|......:|
Zfish   184 DGGGGGGGGDDVDGALEKPTRRKRGSRKRETQTTPRITIKLVAKKTVVTVPTLRRKPGRRPKEVK 248

  Fly   407 QDASQQQTAS-SSQHQTHHSRT------AQLTNLDQAVKHKPESEEQPVIT-----------DLS 453
            .:.|:.|.|. ||.|....::|      |..|.::...:.:..|.:|.:.|           |..
Zfish   249 TEVSESQCAQISSAHVKLKTKTPASESSAGDTKVEVCTRRRGRSADQKLETTLQKEPKKEANDQK 313

  Fly   454 YRNSETDKTAANPVPEAPESPYLTTSNEESLESNSNSSNSRKRRKRKASMVMRVTPNENAPEGEN 518
            .:..::.:...||:|...:.|   ...::|.:..|..:....||:|..|   .:.|.|:   |:.
Zfish   314 LKLRKSTRKCQNPLPSENKEP---KPADKSAQEASEVNKLVIRRQRTRS---SIAPQES---GDQ 369

  Fly   519 SKPQHPQQAANLNNSCSPKKSPKNGGGEFQPFSTQKQSQTENEKTTQENGRGGSPAPAENNSNSN 583
            |..:...:.:.::.|.||.|..|           :|:.:.:|.|.::.|    ..:.|:::.:|.
Zfish   370 SLAESQLEVSTIDESRSPSKKKK-----------KKKKKKKNRKESERN----KDSSAKDHGHSA 419

  Fly   584 SSTLY----ND-----------NENPKTK-----------------KQRQALLQRNLTE-QHRMQ 615
            ...|.    ||           ..|||.:                 |.:.:.:|.||:: |....
Zfish   420 DDPLKLAFGNDFVGIPGLKLTRIRNPKARSRKKRCKFVWTLTLVKCKGKDSHIQENLSKTQDPQN 484

  Fly   616 QDD----------------EPPKNHTSPA----MPPPSPQ-----SNSSSSSSSSSSANTHSSQS 655
            |:|                .|.|...||:    :||...:     ..:..:|:.||:..|.|.|.
Zfish   485 QEDLGKTQEIESQDSRVQKSPSKADESPSIEAELPPKCDKEVDVSEEAEPASAPSSTLETDSLQE 549

  Fly   656 SHAVNNIPKPEINNKATTDTPASP------------------ALVEQGDIDAKPAVSVHECDEEE 702
            |.        ::.|.|:|..|.||                  .::|:.:|:|.|..:.   ..|.
Zfish   550 SQ--------KVENTASTVIPESPENPVAIDKDEEIPEKENEEVLERSEIEAHPEEAT---QTEP 603

  Fly   703 EPAVNKVSPAHPD--PPTTAAVAAPP--------------ATESPKKSSP--------AANSE-- 741
            |..:||      |  ||....|.:.|              .|.||:.:.|        ..|||
Zfish   604 EDLINK------DIVPPLQIKVVSSPGKNNSLKQSFLIQQVTTSPEITEPEKVEEHQHLENSENM 662

  Fly   742 -----SCPFGEVEDKLEQMFA---------------------GIEEETERISSPEKPAEESAAMV 780
                 :.|..:|.:||.|..|                     ..|.....|::..:|.||...::
Zfish   663 LQKTTTSPDHKVRNKLHQSAARKKRARHRHWTIYRRKGRTNPSQENSASEIATETEPQEEELLVL 727

  Fly   781 AHNLTAQLALDPSKTLD--TPAENQTSVLAVLAPNQTPTPEIRPVATKAAMKSTM--PS----PV 837
            ...:.|.:...|.:.||  ||...:.||    .|...|.||   .|....::.|:  ||    ||
Zfish   728 PTEVPAPVESKPKRHLDKITPKRGKRSV----PPTAEPLPE---AAEPQVIEQTVEAPSTDLLPV 785

  Fly   838 HSPIPQSRSTSTPLVAGDDSKSNTPVPAKAPAPRRPPPRRLSMGMDASLLRFMIDDPPAKKPGRK 902
            ..|.|:.: ...|.:..::.....|.....|..|||..||:.   .|...|..:.....|....:
Zfish   786 TEPQPEIK-LEAPSIENEEVLVLEPSVKDHPQVRRPLKRRIK---HAKRRRRSLIGRRVKNQKLQ 846

  Fly   903 KKVTKEPDFEDDDKPSTSAAAAAALAARQLSEAAS-------ATKSKPAAGAKKKNAGVKGKKGS 960
            |||..||  .|...|:|.            ||...       |||.|.......::...:.||..
Zfish   847 KKVLVEP--TDGCPPTTE------------SEGGEPKLVGLFATKYKRKRITSIQSLEARRKKAK 897

  Fly   961 AGKGNAKNAKQNGKKSARKP----AFTTDEDSTPAPTNGGGSVPELR--------------FKSP 1007
            ......:|.....:.|.::.    :..||:|....| |....|..:|              .|:|
Zfish   898 FLSKQLENTSSQDQLSTQEESDSFSVKTDQDHDIQP-NKAKIVKNIRHFIMPVVSARSSRVIKTP 961

  Fly  1008 FILIKPDGSVSIKNTHSAEDVNEKQTKVKKAPHERKN---LRGMHSSTLSNRYDADTTDSTWICV 1069
            ...:...|...:...:|.:.:..:....|..|.||..   .:........:..|.|.: |||...
Zfish   962 KRFMDDLGMSDLPRKNSQKKLGLQPKSKKSDPSERGEPGCFQSQDEEDNQSEIDLDLS-STWESK 1025

  Fly  1070 FCKRGPHKLGLGDLFGPYLVTSDCDEYRAAVQTPG---------AQDIDGMFVNKRRREDMVKGQ 1125
              .:.|..:   |||..   .....:.|:.::.||         ::|:...      .||:.|..
Zfish  1026 --PKSPDDI---DLFSE---EKQSGKRRSLLRDPGFKWGVLEPASEDVYSF------GEDLDKEL 1076

  Fly  1126 ERNLPAVPATLANIM-------------QAPKISMHKR-KRKQT 1155
            |..|.|...|:.:.:             |:.|:.::|: |.||:
Zfish  1077 ETLLSAKDFTVDSFLDPVQKKKSTKFKAQSSKLRLYKKLKLKQS 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:473978	21/111 (19%)
kmt2bb	XP_002664717.2	PTZ00121	<466..919	CDD:173412	106/494 (21%)
		rne	<710..817	CDD:236766	27/114 (24%)
		zf-CXXC	1407..1452	CDD:366873
		PHD1_KMT2B	1654..1700	CDD:277064
		PHD2_KMT2B	1702..1750	CDD:277066
		PHD3_KMT2B	1787..1843	CDD:277068
		Bromo_ALL-1	1857..1979	CDD:99925
		ePHD_KMT2A_like	2081..2185	CDD:277134
		FYRN	2232..2279	CDD:461787
		Atrophin-1	<2876..>3077	CDD:460830
		PHA03247	<2945..3337	CDD:223021
		FYRC	3468..3550	CDD:461788
		SET_KMT2A_2B	3619..3772	CDD:380947