DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5098 and kmt2a

DIOPT Version :9

Sequence 1:	NP_001261066.1	Gene:	CG5098 / 37063	FlyBaseID:	FBgn0034300	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	XP_005157640.1	Gene:	kmt2a / 557048	ZFINID:	ZDB-GENE-080521-3	Length:	4219	Species:	Danio rerio

Alignment Length:	1868	Identity:	336/1868 - (17%)
Similarity:	536/1868 - (28%)	Gaps:	751/1868 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PGHLSQA-AQNASWNPLQIPSYIPRQPQLAHMSNERPGMVRSPLAWHVSGT-VSAQPPPPPDA-- 69
            |.|:..| .::|...|...|: .|..|.|...:....|...:|    .||: |.:.|||||..
Zfish   466 PPHMKIARLESALTAPAPQPA-TPSTPALVSTAPSTSGTTATP----GSGSAVESLPPPPPPVST 525

  Fly    70 ------IYNFMSANHKNLDHHHQMNPLLAPPYSGTLPFNSMDLSL-QSARSAAQPL--------- 118
                  ..:.::::..|...:.:.:...|...|..:..:|..||. :|:||.:..|
Zfish   526 GSTTAIAASLLNSSCNNSTSNGRFSSSAASCGSSAVSQHSSQLSSGESSRSTSPSLDDSSCDSQA 590

  Fly   119 ------AKQPPNQQPHQTQQQQQSLIHAPNYPSIQNLTTNATPTSTQLQQQQQ----QEHL--AA 171
                  ..:..:..|....:.:.||.||.:.||   .|:...|....|:..::    |.|.  |.
Zfish   591 SEGTQALSEEADHSPASQGETEASLHHASHPPS---PTSEPEPDHIVLEHSRRGRRGQSHRRGAV 652

  Fly   172 MAAAHVSLLQSSRQNQGAPSGNLSNGGD-------CESLLPPPPPTSVSGNTNHTGSNSSSNSGS 229
            :|....:|:...:|...:|:..:|..|.       ..|..|||||.........|    :|::.:
Zfish   653 VARGRGNLIIGRKQAIISPATGVSQAGSQQASSTASSSSSPPPPPLLSPPQPPQT----ASSNAA 713

  Fly   230 NNHIASPHYMQSRDENFKLTQLKRSFEPDLSGKNPQKEKDFGYPSASSAS--------------- 279
            .:|..||..|......|..|....|...| ..::..:|..|.:.|.|.|.
Zfish   714 EHHSHSPWMMSHSIAPFLPTSSILSSSHD-KRRSILREPTFRWTSLSCAENKYFSSAKYAKEGLI 777

  Fly   280 KLPTHNVQQQHANKKPSPLRNYHQQQQPPYNLTPKYNGPQTP---PTPQSPLAANPHQMLSPTMD 341
            :.||.:      |.:|.||........||..    ..|..|.   |.| ...|....::.||
Zfish   778 RKPTFD------NFRPPPLTAEDVGLMPPVT----GGGGVTSGGFPAP-GGAAGTGTRLFSP--- 828

  Fly   342 YNQLHLHHQLNSSSGGSYQHMQQDQTQSQSHPQHLHYHNQHATSQTAPP-----PLL-PPLLTSG 400
                 |||                      ||.  |.|:||::|:...|     ||| ||..|..
Zfish   829 -----LHH----------------------HPH--HNHHQHSSSRFETPLQKRTPLLRPPFFTPS 864

  Fly   401 QFHAQ--------------PQDASQQQTASSSQHQTHHSRTAQLTNLDQAVKHKPESEEQPVITD 451
            ..|::              |...|..|.:.:|..:...||.:         :.:|.|....:||.
Zfish   865 PAHSRIFESVTLPSSSGSSPGSLSPLQVSPTSSKKKKGSRFS---------RGQPRSPSHSMITR 920

  Fly   452 LSYRNSETDKTA----------------ANPVPEAPESPYLTTSNEE------------------ 482
            .|.....|.|::                ::|:|....||...::..:
Zfish   921 SSQSGVPTGKSSEQSIISSSVPITVTGNSSPLPGVAVSPLAASALTQASFSGFPSGSIGLTSHGV 985

  Fly   483 ----------SLESNSNSSN-------------------------------------------SR 494
                      |:..||.||:                                           ||
Zfish   986 SDGRRAAGGLSVSGNSASSSQLFPLFTPSPQASGGGTGKAGKERGISATRDTGTKEKDREMEKSR 1050

  Fly   495 KRR------------KRKASMVMRVTPNE-------NAPEGENSKPQHPQQAANLNNSCS----- 535
            :|.            ||..|:....:|:.       .|.|...::.:.|.:..::...|:
Zfish  1051 EREKENKRDGRRDWDKRGKSLPSEASPSSISSFFGLEAIEESLTQKRTPGRKKSVTVDCAEASPS 1115

  Fly   536 -----------------------PKKSPKNGGGEFQPFSTQKQSQTENEKTTQENGRGGSPAPAE 577
                                   |:||.::.|       .:::...|......:.|:.|.|.
Zfish  1116 DSAAVQAVGSLSSKGRLTKKGRPPEKSIESEG-------VEREKDKEKLSALTQAGQMGKPP--- 1170

  Fly   578 NNSNSNSSTLYNDNENPKTKKQ-----RQALLQRNLTEQHRMQQDDEPPKNHTSPAMPPPSPQSN 637
             .:.|..|.|....:.|.|.::     ::|..|.|..|:..:|..|:|..         |..:|:
Zfish  1171 -TTTSIDSILDRAEKQPVTDRRVVRLLKKAKAQLNKIEKRELQPGDQPKL---------PGQESD 1225

  Fly   638 SSSSSSSSSSANTHSSQSSHAVNNIPKPEINNKAT--TDTPASPAL--VEQGDI------DAKPA 692
            ||.:|       ....:..|...........|:|.  .|.|...||  .|:..|      |.|.:
Zfish  1226 SSETS-------VRGPRIKHVCRRAAVALGRNRAVFPDDMPTLSALPWEEREKILSSMGNDDKSS 1283

  Fly   693 VSVHECDEEEEPAVNKVSPAHPDPPTTAAVAAPPATESPKKSSPAANSESCPFGEVEDKLEQMFA 757
            |:   ..||.||      |..|..|.|.......|  .|:|...:.....||..:|.:.     .
Zfish  1284 VA---GSEEAEP------PTPPIKPVTRQKTVHEA--PPRKGRRSRRCGQCPGCQVPND-----C 1332

  Fly   758 GIEEETERISSPEKPAEESAAMVAHNLTAQ---------LALDPSKTLDTPAENQTSVLAVLAPN 813
            |:  .|..:..|:        ....|:..|         |...|||.|...|:.:..      ..
Zfish  1333 GV--CTNCLDKPK--------FGGRNIKKQCCKVRKCQNLQWMPSKFLQKQAKGKKD------RR 1381

  Fly   814 QTPTPEIRPVATKA----AMKSTMPSPVHSPIPQSRSTSTPLVAGDDSKSNT-PVPAKAPA--PR 871
            :....|.:.:..|:    |...::|.|...| |:.:|.:.|...|||.:..| |....:||  |:
Zfish  1382 RNKLSEKKELHHKSQCSEASPKSVPPPKDEP-PRKKSETPPPAQGDDKQKQTQPSSPSSPASSPK 1445

  Fly   872 RP----PP-----------------RRLSMGMDASLLRFMIDDPPAKK----------PGRKKKV 905
            .|    ||                 |:.......:.|......|||:.          |.:|:.:
Zfish  1446 DPLLSSPPDDHKHSLTSLSSACRKERKQQPSSSPTFLHAAPSSPPAQSQHSLQQPCQMPAKKEGL 1510

  Fly   906 TKEPDFEDDDKPSTSAAAAAALAARQLSEAASATKSKPAAGAKKKNA----GVKGKKGSAGKGNA 966
            ||.....:..|.|           :|.|:.:|||.:.|.|..||:..    .:|.|
Zfish  1511 TKSQSHTEPKKKS-----------QQQSQPSSATDTAPDAKLKKQTTRCVQPLKPK--------- 1555

  Fly   967 KNAKQNGKKSARKPAFTTDEDSTPAPTNGGGSVPELRFKSPFILIKPDG----SVSIKNTHSAED 1027
              .|:..|:..:..:.|.:..|||:.   ||:..:   |:|:     ||    .|..|..::.|:
Zfish  1556 --PKEKEKQLPKPDSSTLNSQSTPST---GGTAKQ---KAPY-----DGVHRIRVDFKEDYNIEN 1607

  Fly  1028 VNE-------------------------------------------------------------- 1030
            |.|
Zfish  1608 VWEMGGLSILTSVPITPRVVCFLCASSGNVEFVFCQVCCEPFHLFCLGEAERPHDEQWENWCCRR 1672

  Fly  1031 ---------KQTKVKKAPHERKNLRGMHSSTLSNRYDADTTDS--TWICVFCKR----GPHKLG- 1079
                     |..|.|:.....|.....|...|...:....|..  .|:|..|.|    |..|.|
Zfish  1673 CRFCHVCGRKYQKTKQLLECDKCRNSYHPECLGPNHPTRPTKKKRVWVCTKCVRCKSCGATKPGK 1737

  Fly  1080 ------------------------LGDLFGPYLVTSDCD-------------------------- 1094
                                    |..|........|||
Zfish  1738 AWDAQWSHDFSLCHDCAKRLTKGNLCPLCNKGYDDDDCDSKMMKCKKCDRWVHAKCESLTDDMCE 1802

  Fly  1095 ----------------------EYRAA----VQTPGAQDIDGMFVNK------RRREDMVKGQER 1127
                                  |:|..    :|....|.:..:|.::      |.|:.::|..|.
Zfish  1803 LMSSLPENVVYTCTNCTESHPAEWRTVLEKEIQRSMRQVLTALFNSRTSTHLLRYRQAVMKPPEL 1867

  Fly  1128 N------LPA-------VPATLANIM---QAP--KISMHKRKRKQTHDSSISYSDD--------- 1165
            |      ||:       .|..|..:.   .:|  ..|:.|:.....:.|.:.:|||
Zfish  1868 NPETEESLPSRRSPEGPDPPVLTEVSPPNDSPLDLESVEKKMDSGCYKSVLEFSDDIVKIIQTAF 1932

  Fly  1166 --------PNESRSQCSSVDLLDCS--------TESKFVETFR---------------------- 1192
                    ..::.|...|..:....        .||||.||.:
Zfish  1933 NSDGGQLESRKANSMLKSFFIRQMERIFPWYKVKESKFWETSKASSNSGLLPNVVLPPSLDHNYA 1997

  Fly  1193 ---------------------------------------------------------------GM 1194
                                                                           |:
Zfish  1998 QCQEREEIAKAGQSVHMKKIIPAPHPKAPGEPNSLMAPTPPPPPPMLIHDHSLEDSPVIPPPPGV 2062

  Fly  1195 G--------------KTSE------NGFEVWLHEDCAVWSNDIH--LIGAHVNGLDAAVWDSTRY 1237
            |              ||::      .|...|.|.:||:||.:::  :.|| :..:..||....:.
Zfish  2063 GDNRQCALCLNYGDEKTNDCGRLLYIGHNEWAHVNCALWSAEVYEDVDGA-LKNVHMAVSRGKQL 2126

  Fly  1238 QCVLCQQTGASICCFQRCCKAAAHVPCGRSANWSLSEEDRKVYCHLHR 1285
            ||..|.:.||::.|....|....|..|.|....:.. ||:||||..|:
Zfish  2127 QCKNCHKPGATVSCCMTSCTNNYHFMCARQQQCAFL-EDKKVYCQHHK 2173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	71/452 (16%)
kmt2a	XP_005157640.1	zf-CXXC	1312..1359	CDD:251032	9/61 (15%)
		PHD1_KMT2A	1627..1673	CDD:277063	0/45 (0%)
		PHD2_KMT2A	1675..1724	CDD:277065	9/48 (19%)
		PHD3_KMT2A	1762..1818	CDD:277067	5/55 (9%)
		Bromo_ALL-1	1841..1971	CDD:99925	22/129 (17%)
		ePHD_KMT2A	2066..2178	CDD:277163	30/110 (27%)
		FYRN	2220..2266	CDD:283589
		FYRC	3919..4002	CDD:197781
		SET	<4060..4219	CDD:225491
		SET	4081..4201	CDD:214614
		PostSET	4203..4219	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900