DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5098 and G2E3

DIOPT Version :9

Sequence 1:	NP_001261066.1	Gene:	CG5098 / 37063	FlyBaseID:	FBgn0034300	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	NP_060239.2	Gene:	G2E3 / 55632	HGNCID:	20338	Length:	706	Species:	Homo sapiens

Alignment Length:	193	Identity:	47/193 - (24%)
Similarity:	71/193 - (36%)	Gaps:	66/193 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1167 NESR---SQ------CSSVDLLDCSTESKFVETFRGMGKTSENGFEVWLHEDCAVWSNDIHLIGA 1222
            |||:   ||      |...|  ||  .:|:     |..||.|. :.:.:|..|.:.|:.|...|.
Human     2 NESKPGDSQNLACVFCRKHD--DC--PNKY-----GEKKTKEK-WNLTVHYYCLLMSSGIWQRGK 56

  Fly  1223 HVNG--------LDAAVWDSTRYQCVLCQQTGASICCFQRCCKAAAHVPCGRSANWSLSEE---- 1275
            ...|        :...|..:::.:|.:|::.||||.|....||.:.|.|||      |..|
Human    57 EEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCG------LQRECIFQ 115

  Fly  1276 ---DRKVYCHLHRHEPGVVEPIKTESIAPVEVSVAT---PPAPA--------PPPAFNIHSLP 1324
               :...:|..||               ||::..:.   ...|.        |.|::||...|
Human   116 FTGNFASFCWDHR---------------PVQIITSNNYRESLPCTICLEFIEPIPSYNILRSP 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	37/140 (26%)
G2E3	NP_060239.2	ePHD_PHF7_G2E3_like	14..127	CDD:277139	32/128 (25%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971
		HECTc	411..692	CDD:331829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810