DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5098 and Kmt2a

DIOPT Version :9

Sequence 1:	NP_001261066.1	Gene:	CG5098 / 37063	FlyBaseID:	FBgn0034300	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	XP_038938273.1	Gene:	Kmt2a / 315606	RGDID:	1586165	Length:	3986	Species:	Rattus norvegicus

Alignment Length:	1602	Identity:	296/1602 - (18%)
Similarity:	471/1602 - (29%)	Gaps:	582/1602 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QSARSAAQPLAKQPPNQQPHQTQQQQQSLIHAPNYPSIQNLTTNATPTSTQLQQQQQQEHLAAMA 173
            |::.|...||...||..||..........:..|..|    |.:...|.|....|.:::..|....
  Rat   555 QTSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIP----LASPFLPASAAPMQGKRKSILREPT 615

  Fly   174 AAHVSLLQSSRQNQGAPSGNLSNGGDCESLLPPP------PPTSVSGNTNHTGSNSSSNSGSNNH 232
            ....||..|..:.|...|...:.    |.|:..|      ||.....:.......|:|.|.::..
  Rat   616 FRWTSLKHSRSEPQYFSSAKYAK----EGLIRKPIFDNFRPPPLTPEDVGFASGFSASGSAASAR 676

  Fly   233 IASPHYMQSRDENFKLTQLKRS--FEPDLSGKNPQKEKDFGYPSASSASKLPTHNVQQQHANKKP 295
            :.||.:..:|.:..|.:.:.|:  |.|  |..:.:..:....||..::|...:..|..:...:|.
  Rat   677 LFSPLHSGTRFDIHKRSPILRAPRFTP--SEAHSRIFESVTLPSNRTSSGASSSGVSNRKRKRKV 739

  Fly   296 -SPLRNYHQQQQPPYNLTPKYN-------GPQTPPT--------PQSPLAANPHQMLSPTMDYNQ 344
             ||:|:  :.:.|.:::..:..       .|.|||:        |.|||||:   .|:||..:..
  Rat   740 FSPIRS--EPRSPSHSMRTRSGRLSTSELSPLTPPSSVSSSLSIPVSPLAAS---ALNPTFTFPS 799

  Fly   345 LHLHHQLNSSSGGSYQHMQQDQTQSQSHPQHLHYHNQHATSQTAPP-----PLLPPLLTSGQFHA 404
                |.| :.||.|.:..|:.:.|               ||..|.|     |.|.|..|.|
  Rat   800 ----HSL-TQSGESTEKSQRARKQ---------------TSAPAEPFSSNSPALFPWFTPG---- 840

  Fly   405 QPQDASQQQTASSSQHQTHHSRTAQLTNLDQAVKHKPESEEQPVITDLSYRNSETDKTAANPVPE 469
                   .||....:..|.....::..:.|::|: |.:|.|         |:.|.:|
  Rat   841 -------SQTEKGRKKDTAPEELSKDRDADKSVE-KDKSRE---------RDREREK-------- 880

  Fly   470 APESPYLTTSNEESLESNSNSSNSRKRRKRKASMVMRVTPNENAPEGENSKPQHPQQAANLNNSC 534
                              .|...|||.:::|.|.:.  :.:...|.|..||.:...:....::|.
  Rat   881 ------------------ENKRESRKEKRKKGSDIQ--SSSALYPVGRVSKEKVAGEDVGTSSSA 925

  Fly   535 S-----PKKSPKNGGGEFQPFSTQKQSQTENEKTTQENGRGG----------------------- 571
            .     .|.|..:.|.:..|. |...:.....|...:.|||.
  Rat   926 KKATGRKKSSSLDSGADIAPV-TLGDTTAVKAKILIKKGRGNLEKNNLDLGPTAPSLEKEKTLCL 989

  Fly   572 ---SPAPAENNSNSNSSTLYNDNENPKTKKQRQALLQR------NLTEQHRMQQDDEPPKNHTSP 627
               ||:..:::::|..|.|...::.|.|.|:..:||::      .:.:...::|.|:|
  Rat   990 STPSPSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQP------- 1047

  Fly   628 AMPPPSPQSNSSSSSSSSSSANTHSSQSSHAVNNIPKPEINNKAT--TDTPASPAL--VEQGDI- 687
                     .:....|.||..:....:..|............:|.  .|.|...||  .|:..|
  Rat  1048 ---------KAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKIL 1103

  Fly   688 -----DAKPAVSVHECDEEEEPAVNKVSP-----AHPDPPT-----TAAVAAPPATESPKKSSPA 737
                 |.|.:::..|..|...|.:..:.|     |..:||.     :......|..:.|:.....
  Rat  1104 SSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC 1168

  Fly   738 ANSESCP-FGEVEDK--------------------LEQMFAGIEEETERISSPEKPAEESAAMVA 781
            .|....| ||....|                    |::....::::.::..:.||...:.:.:|.
  Rat  1169 TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQTKAVKKKEKKSKATEKKESKESTVVK 1233

  Fly   782 HNL-TAQLALDPSKTLDT------------PAENQTSVLAVLAPNQTPTPEIRPVATKAAMKSTM 833
            .:| :||.|..|.:....            |.|.:|......||...|.|...|        :..
  Rat  1234 SSLESAQKAAPPVREEPAPKKSSSEPPPRKPVEEKTEEGGAPAPAPAPAPAPAP--------APA 1290

  Fly   834 PSPVHSPIPQSRSTSTPLVAGDDSKSNTPVPAKAPAPRRPPPRRLSMGMDASLLRFMIDDPPAKK 898
            |:|..:|.|:.:..|||  |...|......|| |..|.:||...|   ......:.:..:|..|:
  Rat  1291 PAPAPAPAPEPKQASTP--ASRKSSKQVSQPA-AVVPPQPPSTAL---QKKEAPKAIPSEPKKKQ 1349

  Fly   899 P---------GRKKKVTKEPDFEDDDKPSTSAAAAAALAARQLSEAASATKSKPAAGAKKKNAGV 954
            |         .::|||...|......||.                    .|.||...:|::|||.
  Rat  1350 PPPPESGPEQSKQKKVAPRPSIPVKQKPK--------------------DKEKPPPVSKQENAGT 1394

  Fly   955 KGKKGSAGKGNAKNAKQNGKKSARK-PA---------FTTDEDSTPAPTNGG----GSVPELRFK 1005
            .         |..|...||..|.:| ||         |..|.::......||    .||| :..:
  Rat  1395 L---------NILNPLLNGISSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVP-ITPR 1449

  Fly  1006 SPFILIKPDGSVSI----------------KNTHSAEDVNE--------------KQTKVKKAPH 1040
            ....|....|.|..                :|....||..|              :|.:..|...
  Rat  1450 VVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLL 1514

  Fly  1041 ERKNLR-GMHSSTLSNRYDADTT--DSTWICVFCKR----GPHKLGLG----------------- 1081
            |....| ..|...|...|....|  ...|||..|.|    |....|.|
  Rat  1515 ECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAK 1579

  Fly  1082 ------------------DLFGPYLVTSDCD---------------------------------- 1094
                              |.....:....||
  Rat  1580 LFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCEGLSGTEDEMYEILSNLPESVAYTCVN 1644

  Fly  1095 --------------------------------------EYRAAVQTPGAQ--------------- 1106
                                                  .||.|.:.|...
  Rat  1645 CTERHPAEWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEG 1709

  Fly  1107 ------------------DIDGMFVNKRR-----------REDMVK----------GQ------- 1125
                              |::|  |.|:.           .:|:||          ||
  Rat  1710 PDPPVLTEVSKQDEQQPLDLEG--VKKKMDQGNYVSVLEFSDDIVKIIQAAINSDGGQPEIKKAN 1772

  Fly  1126 -----------ERNLPAVPATLANIMQAPKISM---------------HKRKRKQTHDSSISYSD 1164
                       ||..|......:...:..|:|.               |...:.|..:.| |:::
  Rat  1773 SMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSNNSGMLPNAVLPPSLDHNYAQWQEREES-SHTE 1836

  Fly  1165 DP--------------------------------NESRSQCSSVDL-----LDCSTESKFVETFR 1192
            .|                                :..||:..|.:|     :|.:.:......:
  Rat  1837 QPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELHPPPGIDDNRQCALCLMY- 1900

  Fly  1193 GMGKTSEN--------GFEVWLHEDCAVWS------NDIHLIGAHVNGLDAAVWDSTRYQCVLCQ 1243
              |..|.|        |...|.|.:||:||      :|..|...|:     ||....:.:|..||
  Rat  1901 --GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHM-----AVIRGKQLRCEFCQ 1958

  Fly  1244 QTGASICCFQRCCKAAAHVPCGRSANWSLSEEDRKVYCHLHR 1285
            :.||::.|....|.:..|..|.|:.| .:..:|:||||..||
  Rat  1959 KPGATVGCCLTSCTSNYHFMCSRAKN-CVFLDDKKVYCQRHR 1999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	68/464 (15%)
Kmt2a	XP_038938273.1	zf-CXXC	1145..1192	CDD:366873	7/46 (15%)
		PHD1_KMT2A	1451..1497	CDD:277063	7/45 (16%)
		PHD2_KMT2A	1499..1548	CDD:277065	11/48 (23%)
		PHD3_KMT2A	1586..1645	CDD:277067	3/58 (5%)
		Bromo_ALL-1	1668..1798	CDD:99925	16/131 (12%)
		ePHD_KMT2A	1892..2004	CDD:277163	33/117 (28%)
		FYRN	2045..2092	CDD:399155
		FYRC	3686..3769	CDD:197781
		SET_KMT2A_2B	3833..3986	CDD:380947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910