DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5098 and Rai1

DIOPT Version :9

Sequence 1:	NP_001261066.1	Gene:	CG5098 / 37063	FlyBaseID:	FBgn0034300	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	NP_001258136.1	Gene:	Rai1 / 303188	RGDID:	1308500	Length:	1887	Species:	Rattus norvegicus

Alignment Length:	1753	Identity:	328/1753 - (18%)
Similarity:	512/1753 - (29%)	Gaps:	629/1753 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HPHPGHLSQA---AQNASWNPLQIPSYIPRQPQLAHMSNERPGMVRSPLAWHVSGTVSAQPPPPP 67
            :.|.|...|.   |..|...|.|.  |....|..:|......|  |||       :.|:.|.|..
  Rat   293 YQHYGQQGQGYCPADTAVRTPEQY--YQTFSPSSSHSPARSVG--RSP-------SYSSTPSPLM 346

  Fly    68 DAIYNFMSANHK---------NLDHHHQMNPLLAPPYSGT------------------LPFNSM- 104
            ..:.||..:...         ..||.|.| |||.|..:..                  ||.|.:
  Rat   347 PNLENFPYSQQPLSTGAFPTGITDHSHFM-PLLNPSPTDAASSVDPQVSNCKPLQKEKLPDNLLS 410

  Fly   105 DLSLQ-------------------------------------------------------SARSA 114
            |||||                                                       ||..|
  Rat   411 DLSLQSLTALTSQVENISNTVQQLLLSKATIPQKKGVKNLVSRTPEQHKSQHCSPEGSGYSAEPA 475

  Fly   115 AQPLAKQPPNQQPHQTQQQQQ--------------SLIH---APNYPSIQNLTTNATP------- 155
            ..||: :||:..|..|..:.|              |.::   |...|:..|..:.|.|
  Rat   476 GTPLS-EPPSSTPQSTHAEPQDTDYLSGSEDPLERSFLYCSQARGSPARVNSNSKAKPESVSTCS 539

  Fly   156 ------TSTQLQQQQQQEH----------------------LAAMA----AAHVSLLQ------- 181
                  .||:.....|..|                      |:|:|    |:.:..||
  Rat   540 VTSPDDMSTKSDDSFQSLHSTLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIVEKA 604

  Fly   182 --------SSRQNQGAPSGNLSNGGDC--------------ESLLPPPPPTSVSGNTNHTGSNSS 224
                    |..::.|.|..:|.|...|              ...||.|......|:|..
  Rat   605 DKAWAEASSLPKDNGKPPFSLENHSTCLDTVAKTSWSQPGEPEALPEPLQLDKGGSTKD------ 663

  Fly   225 SNSGSNNHIASPHYMQSRDENFKLTQLKRSFEP-------------------------------D 258
                     .||...:.....|..|..|::..|                               .
  Rat   664 ---------FSPGLFEDPSVAFATTDPKKTTSPLSFGTKPLLGTATPDPTTAAFDCFPDTTTASS 719

  Fly   259 LSGKNP----------------------QKEKDFGYPSASSASKLPTHNV------QQQHANKKP 295
            :.|.||                      .|..:.|..::.|..|...|..      |::||..||
  Rat   720 VDGANPFAWPEENLGDACPRWGLHPGELTKGLEQGAKASDSVGKADAHETSACLGFQEEHAIGKP 784

  Fly   296 -SPLRNYHQQQQ-------------------------------------------PP-------- 308
             :.|....:||:                                           ||
  Rat   785 AAALSGDFKQQEADGVKEEVGGLLQCPEVGKADQWLEDSRHCCSSADFGDLPLLPPPGRKEDLEA 849

  Fly   309 ----YNLTPKYNGPQTPPTPQSPLAANPHQMLSPTMDYNQLHLHHQLNSSSGGSYQHMQQDQTQS 369
                .:|......|:..|:.|.||  :|...|..|.:    .....|::.:|
  Rat   850 EEEYSSLCELLGSPEQRPSLQDPL--SPKAPLICTKE----EAEEVLDTKAG------------- 895

  Fly   370 QSHPQHLHYHNQHATSQTAPPPLLPPLL----------TSGQFHAQPQDASQQQTASSSQHQTHH 424
            .:.|.||         ...|..||.|.:          .|...|.:|.:..:.:.|..|. .|..
  Rat   896 WASPCHL---------SGEPAVLLGPSVGAESKVQSWFESSLSHMKPGEGPELERAPGSA-STSQ 950

  Fly   425 SRTAQLTNLDQAVKHKPESEEQPVITDLSYRNSETDKTAANPVPEAPESPYLTTSNEESLESNSN 489
            ...|...| ..||...|.::::||....|.|:....:    .:|||.:||....:..:.|....:
  Rat   951 GSLAPKPN-TPAVPEGPIAKKEPVPRGKSLRSRRVHR----GLPEAEDSPCRAPALPKDLLLPES 1010

  Fly   490 SSNSRKRRKRKASMVMRVTPNENAPEG----------ENSKPQHPQQAANLNNSCSPKKSPKNGG 544
            .:...:.:...|.     .|.....||          ..|:||.|...   ..:.:|....|.||
  Rat  1011 CTGPPQGQAEGAG-----APGRGLSEGLPRMCTRSLTALSEPQTPGPP---GLTTTPTPPDKLGG 1067

  Fly   545 GEFQPFSTQKQSQTENEKTTQENGRGGSPAPAENNSNSNSSTL-YNDNENP---KTK-------- 597
            .:...|.:.|              |.|.|:|...:|.||.:.| ...:.:|   |||
  Rat  1068 KQRAAFKSGK--------------RVGKPSPKAASSPSNPAALPVASDSSPMGSKTKEPDSPGMP 1118

  Fly   598 -KQRQALLQRNLTEQHRM--QQDDEPPKNHTSPAMPPPSPQSNSSSSSSSSSSANTHSSQSSHAV 659
             |.:::::.|:.|:..::  .:...|.::......|...|.:|:...::...|:...........
  Rat  1119 GKDQRSMVLRSRTKPQQVFHAKRRRPSESRIPDCRPTKKPPANNHLPTAFKVSSGPQKEGRMSQR 1183

  Fly   660 NNIPKPEINNKATTDTPASPALVEQGDIDAKPA--------------VSVHECDEEEEPAV--NK 708
            ..:|||...:| .:|.|......:...:...||              |...|...|..|.:  ..
  Rat  1184 GKVPKPGTGSK-LSDRPLHTLKRKSAFMAPVPAKKRSLILRSNNGSGVDGREERAESSPGLLRRM 1247

  Fly   709 VSPAHPDPPTTAAVAAPPATESPKKSSPAANSESCPFGEVEDKLEQMFAG----IEEETERISSP 769
            .||....|..:.....||..|.|......|...|.| ..|..|:.....|    :|...::|:||
  Rat  1248 ASPQRARPRGSGEPPPPPPLEPPAACLGLATQSSLP-SAVRTKVLPPRKGRGLKLEAIVQKITSP 1311

  Fly   770 EKPAEESAAMVA---HNLTAQLALDPSKTLDTPAENQTSVLAVLAPNQTPT-----PEIRPVATK 826
              ..::.|..||   .......||...::..:||..:..|..:.|....|.     |..|..|:.
  Rat  1312 --GLKKLACRVAGAPPGTPRSPALPEKRSGGSPAGAEEGVGGMGAGQMLPAASGADPLCRNPASS 1374

  Fly   827 AAMK------------------------STMPSPVHSPIPQSRSTSTPLVAGDDSKSNTPVPAKA 867
            .::|                        .|:||...:..|:.||..        .::....|:|.
  Rat  1375 RSLKGKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRK--------GRTGALGPSKG 1431

  Fly   868 PAPRRPPPRRLSMGMDASLLRFMIDDPPAKKPGRKKKVTKEPDFEDDD-----KPSTSAAAAAAL 927
            |..:||.|.:       :|:....|...:.:.|.          ||:.     ||.|.....|
  Rat  1432 PLEKRPCPGQ-------ALILAPHDRASSTQGGG----------EDNSSGGGKKPKTEELGLA-- 1477

  Fly   928 AARQLSEAASATKSKPAAGAKKK------NAGVKGKKGSAGKGNAKNAKQ-NGKKSARKPAFTTD 985
                 |:.......:|...|:|:      ::..|.|:.|.|:|.|.:|.. .|:.:.|:......
  Rat  1478 -----SQPPEGRPCQPQTRAQKQPGQASYSSYSKRKRLSRGRGKATHASPCKGRATRRRQQQVLP 1537

  Fly   986 EDSTPAPTNGGGSVPELRFK-----------------SPFILI--------------------KP 1013
            .|  ||.       ||:|.|                 |||:.:                    ||
  Rat  1538 LD--PAE-------PEIRLKYISSCKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKP 1593

  Fly  1014 ---DGSVSIKNTHSAEDVNEKQTK------VKKAP----HERKNLRGMHSSTLSNRYDADTTDST 1065
               ..||:..:|.|:|......|.      ::..|    ....:|..:.|..||.        |.
  Rat  1594 HWKPSSVASSSTSSSEPAGASLTTFPGGSVLQLRPSLPLSSTMHLGPVVSKALST--------SC 1650

  Fly  1066 WICVFCKRGPHKLGLGDLFGPYLVTSDCDEYRAAVQTPGAQDIDGMFVNKRRREDMVKGQERNLP 1130
            .:|..|:...:...||||.|||.     .|:....:.|..::       |.|.|..:  :|.:||
  Rat  1651 LVCCLCQNPANFKDLGDLCGPYY-----PEHCLPKKKPKLKE-------KVRLEGTL--EEASLP 1701

  Fly  1131 ----------------AVPATLA-------NIMQAPKISMHKRKRKQTHDSSISYS--------- 1163
                            |.|.|..       ..:..|.......|:.....|:...|
  Rat  1702 LERTLKGLECAASTTAATPTTTTITTTTTLGRLSRPDGPADPAKQGSLRTSARGLSRRLQSCYCC 1766

  Fly  1164 DDPNESRSQCSSVDLL---DCSTESKFVETFRGMGKTSENGFEVWLHEDCAVWSNDIHLIGAHVN 1225
            |...:...:.:..|..   :||.|:    .....|.|.|:    |:||.||||::.::|:...:.
  Rat  1767 DGQGDGGEEVAPADKSRKHECSKEA----PAEPGGDTQEH----WVHEACAVWTSGVYLVAGKLF 1823

  Fly  1226 GLDAAVWDSTRYQCVLCQQTGASICCFQRCCKAAAHVPCGRSANWSLSEEDRKVYCHLHRHEP 1288
            ||..|:..:....|..|.::||:|.|....|....|.||......:..||:..:.|..|:..|
  Rat  1824 GLQEAMKVAVDMPCTSCHESGATISCSYEGCTHTYHYPCANDTGCTFIEENFTLKCPKHKRLP 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	56/250 (22%)
Rai1	NP_001258136.1	PHA03247	<941..1200	CDD:223021	57/287 (20%)
Rai1	NP_001258136.1	PHD_SF	1653..1882	CDD:419867	56/250 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4462
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14955
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.080