DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5098 and Kmt2a

DIOPT Version :9

Sequence 1:	NP_001261066.1	Gene:	CG5098 / 37063	FlyBaseID:	FBgn0034300	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	NP_001344478.1	Gene:	Kmt2a / 214162	MGIID:	96995	Length:	3966	Species:	Mus musculus

Alignment Length:	1608	Identity:	301/1608 - (18%)
Similarity:	476/1608 - (29%)	Gaps:	612/1608 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QSARSAAQPLAKQPPNQQPHQTQQQQQSLIHAPNYPSIQNLTTNATPTSTQLQQQQQQEHLAAMA 173
            |::.|...||...||..||..........:..|..|    |.:...|.|....|.:::..|....
Mouse   554 QTSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIP----LASPFLPASAAPMQGKRKSILREPT 614

  Fly   174 AAHVSLLQSSRQNQGAPSGNLSNGGDCESLLPPP------PPTSVSGNTNHTGSNSSSNSGSNNH 232
            ....||..|..:.|...|...:.    |.|:..|      ||.....:.......|:|.:.::..
Mouse   615 FRWTSLKHSRSEPQYFSSAKYAK----EGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASAR 675

  Fly   233 IASPHYMQSRDENFKLTQLKRS--FEPDLSGKNPQKEKDFGYPSASSASKLPTHNVQQQHANKKP 295
            :.||.:..:|.:..|.:.:.|:  |.|  |..:.:..:....||..::|...:..|..:...:|.
Mouse   676 LFSPLHSGTRFDIHKRSPILRAPRFTP--SEAHSRIFESVTLPSNRTSSGASSSGVSNRKRKRKV 738

  Fly   296 -SPLRNYHQQQQPPYNLTPKYN-------GPQTPPT--------PQSPLAANPHQMLSPTMDYNQ 344
             ||:|:  :.:.|.:::..:..       .|.|||:        |.|||||:   .|:||..:..
Mouse   739 FSPIRS--EPRSPSHSMRTRSGRLSTSELSPLTPPSSVSSSLSIPVSPLAAS---ALNPTFTFPS 798

  Fly   345 LHLHHQLNSSSGGSYQHMQQDQTQSQSHPQHLHYHNQHATSQTAPP-----PLLPPLLTSGQFHA 404
                |.| :.||.|.:..|:.:.|               ||..|.|     |.|.|..|.|
Mouse   799 ----HSL-TQSGESTEKNQRARKQ---------------TSALAEPFSSNSPALFPWFTPG---- 839

  Fly   405 QPQDASQQQTASSSQHQTHHSRTAQLTNLDQAVKHKPESEEQPVITDLSYRNSETDKTAANPVPE 469
                   .||....:..|.....::..:.|::|: |.:|.|         |:.|.:|
Mouse   840 -------SQTEKGRKKDTAPEELSKDRDADKSVE-KDKSRE---------RDREREK-------- 879

  Fly   470 APESPYLTTSNEESLESNSNSSNSRKRRKRKASMVMRVTPNENAPEGENSKPQHPQQAANLNNSC 534
                              .|...|||.:::|.|.:.  :.:...|.|..||.:...:....::|.
Mouse   880 ------------------ENKRESRKEKRKKGSDIQ--SSSALYPVGRVSKEKVAGEDVGTSSSA 924

  Fly   535 S-----PKKSPKNGGGEFQPFSTQKQSQTENEKTTQENGRG---------GSPAPA--------- 576
            .     .|.|..:.|.:..|. |...:.....|...:.|||         |..||:
Mouse   925 KKATGRKKSSSLDSGADVAPV-TLGDTTAVKAKILIKKGRGNLEKNNLDLGPAAPSLEKERTPCL 988

  Fly   577 --------ENNSNSNSSTLYNDNENPKTKKQRQALLQR------NLTEQHRMQQDDEPPKNHTSP 627
                    :::::|..|.|...::.|.|.|:..:||::      .:.:...::|.|:|
Mouse   989 SAPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQP------- 1046

  Fly   628 AMPPPSPQSNSSSSSSSSSSANTHSSQSSHAVNNIPKPEINNKAT--TDTPASPAL--VEQGDI- 687
                     .:....|.||..:....:..|............:|.  .|.|...||  .|:..|
Mouse  1047 ---------KAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKIL 1102

  Fly   688 -----DAKPAVSVHECDEEEEPAVNKVSPAHPDPPTTAAVAAPPATESP--KKSSPAANSESCPF 745
                 |.|.:|:   ..|:.||....:.|..|       |....|.:.|  ||...:.....||.
Mouse  1103 SSMGNDDKSSVA---GSEDAEPLAPPIKPIKP-------VTRNKAPQEPPVKKGRRSRRCGQCPG 1157

  Fly   746 GEV-ED-----------------------------KLEQM--FAGIEEETERISSPE-------- 770
            .:| ||                             .|:.|  .|.::::|:.:...|
Mouse  1158 CQVPEDCGICTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKASLQKQTKAVKKKEKKSKTTEK 1222

  Fly   771 KPAEESAAMVAHNLTAQLALDPSKTLDTPAENQTSVLAVLAPNQTPTPEIRPVATKAAMKSTMPS 835
            |.::||.|:.:....||.|..|.:  :.||..::|        ..|.|. :||..|:. :...|:
Mouse  1223 KESKESTAVKSPLEPAQKAAPPPR--EEPAPKKSS--------SEPPPR-KPVEEKSE-EGGAPA 1275

  Fly   836 PVHSPIPQSRSTSTPLVAGDDSKSNTP-----------VPAKAPAPRRPP--PRRLSMGMDASLL 887
            |  :|.|:.:..|.|.......:.:.|           .|.|..||:..|  |::
Mouse  1276 P--APAPEPKQVSAPASRKSSKQVSQPAAVVPPQPPSTAPQKKEAPKAVPSEPKK---------- 1328

  Fly   888 RFMIDDPPAKKPG----RKKKVTKEPDFEDDDKPSTSAAAAAALAARQLSEAASATKSKPAAGAK 948
                ..||..:||    ::|||...|......||.                    .|.||...:|
Mouse  1329 ----KQPPPPEPGPEQSKQKKVAPRPSIPVKQKPK--------------------DKEKPPPVSK 1369

  Fly   949 KKNAGVKGKKGSAGKGNAKNAKQNGKKSARK-PA---------FTTDEDSTPAPTNGG----GSV 999
            ::|||..         |..|...||..|.:| ||         |..|.::......||    .||
Mouse  1370 QENAGTL---------NILNPLSNGISSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSV 1425

  Fly  1000 PELRFKSPFILIKPDGSVSI----------------KNTHSAEDVNE--------------KQTK 1034
            | :..:....|....|.|..                :|....||..|              :|.:
Mouse  1426 P-ITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQ 1489

  Fly  1035 VKKAPHERKNLR-GMHSSTLSNRYDADTT--DSTWICVFCKR----GPHKLGLG----------- 1081
            ..|...|....| ..|...|...|....|  ...|||..|.|    |....|.|
Mouse  1490 ATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSL 1554

  Fly  1082 ------------------------DLFGPYLVTSDCD---------------------------- 1094
                                    |.....:....||
Mouse  1555 CHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPESV 1619

  Fly  1095 --------------------------------------------EYRAAVQTPGAQ--------- 1106
                                                        .||.|.:.|...
Mouse  1620 AYTCVNCTERHPAEWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPS 1684

  Fly  1107 ------------------------DIDGMFVNKRR-----------REDMVK----------GQ- 1125
                                    |::|  |.||.           .:|:||          ||
Mouse  1685 RSSPEGPDPPVLTEVSKQDEQQPLDLEG--VKKRMDQGSYVSVLEFSDDIVKIIQAAINSDGGQP 1747

  Fly  1126 -----------------ERNLPAVPATLANIMQAPKISM---------------HKRKRKQTHDS 1158
                             ||..|......:...:..|:|.               |...:.|..:.
Mouse  1748 EIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSNNSGMLPNAVLPPSLDHNYAQWQEREE 1812

  Fly  1159 SISYSDDP--------------------------------NESRSQCSSVDL-----LDCSTESK 1186
            | |:::.|                                :..||:..|.:|     :|.:.:..
Mouse  1813 S-SHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIDDNRQCA 1876

  Fly  1187 FVETFRGMGKTSEN--------GFEVWLHEDCAVWS------NDIHLIGAHVNGLDAAVWDSTRY 1237
            ....:   |..|.|        |...|.|.:||:||      :|..|...|:     ||....:.
Mouse  1877 LCLMY---GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHM-----AVIRGKQL 1933

  Fly  1238 QCVLCQQTGASICCFQRCCKAAAHVPCGRSANWSLSEEDRKVYCHLHR 1285
            :|..||:.||::.|....|.:..|..|.|:.| .:..:|:||||..||
Mouse  1934 RCEFCQKPGATVGCCLTSCTSNYHFMCSRAKN-CVFLDDKKVYCQRHR 1980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	69/464 (15%)
Kmt2a	NP_001344478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Menin-binding motif (MBM). /evidence=ECO:0000250\|UniProtKB:Q03164	6..25
		Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250\|UniProtKB:Q03164	121..132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..231
		Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250\|UniProtKB:Q03164	145..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..343
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..590		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..943		63/305 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1003		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1034..1064		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1101..1161		16/69 (23%)
		zf-CXXC	1144..1191	CDD:251032	7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1196..1390		55/250 (22%)
		PHD1_KMT2A	1432..1478	CDD:277063	7/45 (16%)
		PHD2_KMT2A	1480..1529	CDD:277065	11/48 (23%)
		PHD3_KMT2A	1567..1626	CDD:277067	3/58 (5%)
		Interaction with histone H3K4me3. /evidence=ECO:0000250\|UniProtKB:Q03164	1583..1599		2/15 (13%)
		Bromo_ALL-1	1649..1779	CDD:99925	17/131 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1665..1714		6/50 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1807..1870		8/63 (13%)
		ePHD_KMT2A	1873..1985	CDD:277163	33/117 (28%)
		FYRN	2026..2073	CDD:310506
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2147..2174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2214..2339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2371..2619
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2709..2759
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q03164	2843..2851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2958..3060
		Herpes_BLLF1	<3152..>3361	CDD:330317
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3164..3239
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3462..3640
		FYRC	3666..3749	CDD:197781
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:Q03164	3759..3764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3782..3805
		SET	3828..3948	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q03164	3903..3904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810