Protein Alignment CG5098 and RAI1

DIOPT Version :9

• Sequence 1: NP_001261066.1
• Gene: CG5098 / 37063
• FlyBaseID: FBgn0034300
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_016879514.1
• Gene: RAI1 / 10743
• HGNCID: 9834
• Length: 1967
• Species: Homo sapiens
• Alignment Length: 1955
• Identity: 352/1955 - (18%)
• Similarity: 535/1955 - (27%)
• Gaps: 783/1955 - (40%)

  Fly     4 NNHPHPGHLSQAAQNASWNPLQIP---------------------SYIPRQPQLAHMSNERPGMV 47
            ::.|:||..:......:|...|.|                     :.:|...|.|....:.|...
Human   104 DSSPYPGRYAGEESLQAWGAPQPPPPQPQPLPAGVAKYDENLMKKTAVPPSRQYAEQGAQVPFRT 168

  Fly    48 RSPLAWHVSGTVSAQPPPPPDAIYNFMSANHKNLDHHHQMNPLLAP---PYSGTLPFNSMDLSLQ 109
            .|   .||.     |||||...:      .:..|......|.:.:|   |.....|.:|......
Human   169 HS---LHVQ-----QPPPPQQPL------AYPKLQRQKLQNDIASPLPFPQGTHFPQHSQSFPTS 219

  Fly   110 SARSAAQPLAKQ---------PPNQQPHQTQQQQQSLIHAPNYPSIQNL----TTNATPTSTQLQ 161
            |..|::.....|         .|..|||.......|.: ||. ..:|||    :...:....|.|
Human   220 STYSSSVQGGGQGAHSYKSCTAPTAQPHDRPLTASSSL-APG-QRVQNLHAYQSGRLSYDQQQQQ 282

  Fly   162 QQQQQEHLAAMAAAHVSLLQSSRQN---------QGAPSGNLSNGGDCESLLPPPPPTSVSGNTN 217
            |||||:...|:.:.|.:......||         ||.        |.|:    |...........
Human   283 QQQQQQQQQALQSRHHAQETLHYQNLAKYQHYGQQGQ--------GYCQ----PDAAVRTPEQYY 335

  Fly   218 HTGSNSSSNSGSNNHIASPHYMQSRD------ENFKLTQLKRSFEPDLSGKNPQKEKDFGY---- 272
            .|.|.|||:|.:.:...||.|..:..      |||..:|     :|..:|..|....|..:
Human   336 QTFSPSSSHSPARSVGRSPSYSSTPSPLMPNLENFPYSQ-----QPLSTGAFPAGITDHSHFMPL 395

  Fly   273 --PSASSASKLPTHNVQQQHANKKPSPLRNYHQQQQPPYNLTPKYNGPQTPPTPQSPLAANPHQM 335
              ||.:.|    |.:|..|..|.||.      |:.:.|.||....:        ...|.|...|:
Human   396 LNPSPTDA----TSSVDTQAGNCKPL------QKDKLPENLLSDLS--------LQSLTALTSQV 442

  Fly   336 LSPTMDYNQLHLHHQLNSSSGGSYQHMQQDQTQSQSHPQHLHYHNQHATSQTAPPPLL-PPLLTS 399
            .:.:....||.|.........|....:  .:|..|...||........:::.|..||. ||..|.
Human   443 ENISNTVQQLLLSKAAVPQKKGVKNLV--SRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTP 505

  Fly   400 GQFHAQPQDASQQQTASSSQHQTHHS------RTAQLTNLDQAVKHKPESEEQPVIT---DLSYR 455
            ...||:||:|..   .|.|:.....|      .......::...|.||||.....:|   |:|.:
Human   506 QSTHAEPQEADY---LSGSEDPLERSFLYCNQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTK 567

  Fly   456 NSETDKTAANPVP-----------------------------------------------EAP-- 471
            :.::.::....:|                                               |||
Human   568 SDDSFQSLHGSLPLDSFSKFVAGERDCPRLLLSALAQEDLASEILGLQEAIGEKADKAWAEAPSL 632

  Fly   472 -----ESPYLTTSNEESLESNSNSSNSRKRRKRKASMVMRVTPNENA------------------ 513
                 :.|:...::...|:|.:.|:..|..........:::....||
Human   633 VKDSSKPPFSLENHSACLDSVAKSAWPRPGEPEALPDSLQLDKGGNAKDFSPGLFEDPSVAFATP 697

  Fly   514 -------PEGENSKP------QHPQQAANLNNSCSPKKSPKNGGGEFQPFSTQKQS--------- 556
                   |....:||      ..|..||   ..|.|..:..:......||:..:::
Human   698 DPKKTTGPLSFGTKPTLGVPAPDPTTAA---FDCFPDTTAASSADSANPFAWPEENLGDACPRWG 759

  Fly   557 --QTENEKTTQENGRGGSPAPAENNSNSNSSTLYNDNENPK------------------TKKQRQ 601
              ..|..|..::.|: .|...::.:::..|:.|....|:|.                  .|::..
Human   760 LHPGELTKGLEQGGK-ASDGISKGDTHEASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAG 823

  Fly   602 ALLQ--------RNLTEQHR-----------------MQQDDEPPKNHTS-----------PAMP 630
            .|||        |.|.:...                 .::|.|..:.::|           |.|.
Human   824 GLLQCPEVAKADRWLEDSRHCCSTADFGDLPLLPPTSRKEDLEAEEEYSSLCELLGSPEQRPGMQ 888

  Fly   631 PP-------------------------SPQSNSSSS--------SSSSSSANTHSSQSSHAVNNI 662
            .|                         ||...|..|        .:.|...:...|..||.....
Human   889 DPLSPKAPLICTKEEVEEVLDSKAGWGSPCHLSGESVILLGPTVGTESKVQSWFESSLSHMKPGE 953

  Fly   663 PKPEINNKATTDTPASPALVEQGDIDAKPAV--------------------SVHECDEEEE---- 703
            ..|: ..:|..|:..|.|.:.|.  ..||||                    .||....|.|
Human   954 EGPD-GERAPGDSTTSDASLAQK--PNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPC 1015

  Fly   704 --PAVNK-----------------------------------------VSPAHPDPPTTAAVAAP 725
              |.:.|                                         ..|..|.||......||
Human  1016 RAPVLPKDLLLPESCTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAP 1080

  Fly   726 P-----------------ATESPKKSSPAAN-------SESCPFGEVEDKLEQMFAGIEEETERI 766
            |                 ...|||.:|..:|       |:|.|.|              .:|:..
Human  1081 PDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMG--------------SKTKET 1131

  Fly   767 SSPEKPAEESAAMVAHNLTAQLALDPSKTLDTPAE-------------NQTSVLAVLAPNQTPTP 818
            .||..|.::..:|:..:.|....:..||. ..|:|             :.:.:.|....:.:|..
Human  1132 DSPSTPGKDQRSMILRSRTKTQEIFHSKR-RRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQK 1195

  Fly   819 E----------------------IRPVATKAAMKSTMPSPVHSPIPQSRSTSTPLVAGD--DSKS 859
            |                      :..:..|:|..:.:|:...:.:.:|||:|:...:|:  |.|.
Human  1196 EGRVSQRARVPKPGAGSKLSDRPLHALKRKSAFMAPVPTKKRNLVLRSRSSSSSNASGNGGDGKE 1260

  Fly   860 NTP-----------VPAKA--------PAPRRPPPR-------------------------RLSM 880
            ..|           .|.||        ||.:.|||.                         |...
Human  1261 ERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGAMKTKVLPPRKGR 1325

  Fly   881 GMDASLLRFMIDDPPAKK-----PGRKKKVTKEPDFEDDDKPSTSAAAAAALAARQLSEAASATK 940
            |:....:...|..|..||     ||........|...|.|:....|..:.......|....:..|
Human  1326 GLKLEAIVQKITSPSLKKFACKAPGASPGNPLSPSLSDKDRGLKGAGGSPVGVEEGLVNVGTGQK 1390

  Fly   941 SKPAAGA-----KKKNAGVKGK--------------------------------------KGSAG 962
             .|.:||     ...|..:|||                                      ||.||
Human  1391 -LPTSGADPLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAFTSPEALQPGGTALAPKKRSRKGRAG 1454

  Fly   963 -----KG--------------------------NAKNAKQNGKK--------------------- 975
                 ||                          :..|:...|||
Human  1455 AHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASEDNSGGGGKKPKMEELGLASQPPEGRPCQPQ 1519

  Fly   976 --SARKPAFTT--------------DEDSTPAPTNGGG-------------SVPELRFK------ 1005
              :.::|..|.              .:::|.:|..|..             :.||:|.|
Human  1520 TRAQKQPGHTNYSSYSKRKRLTRGRAKNTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCK 1584

  Fly  1006 -----------SPFILI-KPDGSVSIKNTHSAEDVNEKQTKVKKAPHERKNLRGMHSSTLSNRYD 1058
                       |||:.: |.|...:|...     ||......|  || ||......||:.|:.:.
Human  1585 RLRSDSRTPAFSPFVRVEKRDAFTTICTV-----VNSPGDAPK--PH-RKPSSSASSSSSSSSFS 1641

  Fly  1059 ADT------------------------------------TDSTWICVFCKRGPHKLGLGDLFGPY 1087
            .|.                                    :.|..:|..|:...:...||||.|||
Human  1642 LDAAGASLATLPGGSILQPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPY 1706

  Fly  1088 L-----------------VTSDCDEYR------------AAVQTPGAQDIDGMFVNKRRREDMVK 1123
            .                 ....|:|..            ||..|.|          |..|.|.
Human  1707 YPEHCLPKKKPKLKEKVRPEGTCEEASLPLERTLKGPECAAAATAG----------KPPRPDG-- 1759

  Fly  1124 GQERNLPAVPATLANIMQAP-KISMHKRKRKQTHDSSISYSDDPNESRSQCSSVDLLDCSTESKF 1187
                  ||.||     .|.| :.|.....|:..........:|..|..:........:||.|:
Human  1760 ------PADPA-----KQGPLRTSARGLSRRLQSCYCCDGREDGGEEAAPADKGRKHECSKEA-- 1811

  Fly  1188 VETFRGMGKTSENGFEV---WLHEDCAVWSNDIHLIGAHVNGLDAAVWDSTRYQCVLCQQTGASI 1249
                     .:|.|.|.   |:||.||||:..::|:...:.||..|:..:....|..||:.||:|
Human  1812 ---------PAEPGGEAQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVAVDMMCSSCQEAGATI 1867

  Fly  1250 CCFQRCCKAAAHVPCGRSANWSLSEEDRKVYCHLHRHEPGVVEPIKTESIAPVEVSVATPP---A 1311
            .|..:.|....|.||...|                    |...|....::.|::.....||   .
Human  1868 GCCHKGCLHTYHYPCASDA--------------------GTSPPRNRRALEPIQAVQGDPPWAQL 1912

  Fly  1312 PAPPP 1316
            |.|.|
Human  1913 PKPRP 1917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5098	NP_001261066.1	PHD_SF	1068..1284	CDD:304600	57/248 (23%)
RAI1	XP_016879514.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14955
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.980