DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5757 and CDC8

DIOPT Version :9

Sequence 1:	NP_001261065.1	Gene:	CG5757 / 37062	FlyBaseID:	FBgn0034299	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_012591.1	Gene:	CDC8 / 853520	SGDID:	S000003818	Length:	216	Species:	Saccharomyces cerevisiae

Alignment Length:	208	Identity:	90/208 - (43%)
Similarity:	127/208 - (61%)	Gaps:	21/208 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RGALIIFEGCDRSGKTTQSRLLVELLKSKGIPTLP-MNFPERSSSIGQVINSYLT-NSKDLPDEV 68
            ||.||:.||.||:|||||..:|.:.|:    |... :.|||||:.||.:||.||| :|..|.|:.
Yeast     4 RGKLILIEGLDRTGKTTQCNILYKKLQ----PNCKLLKFPERSTRIGGLINEYLTDDSFQLSDQA 64

  Fly    69 IHLMFSANRWEHINQVKEKLLEGTTLVVDRYSFSGVAYSAAK---GLDFDWCYAPERGLIKPDAV 130
            |||:|||||||.::::|:.||||..:|:|||.:|||||||||   |:|.|||..|:.||:|||..
Yeast    65 IHLLFSANRWEIVDKIKKDLLEGKNIVMDRYVYSGVAYSAAKGTNGMDLDWCLQPDVGLLKPDLT 129

  Fly   131 FYLRAPPND-LTHRGQYGKERYEKVEFQGRVAEVFNRICSKEGSYFHQFD--------ARQSVED 186
            .:|.....| ...:..:|.||||.|:||.:|.:.|.::..||   ..:.|        ..:.:::
Yeast   130 LFLSTQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLDKE---IRKGDESITIVDVTNKGIQE 191

  Fly   187 LHAQIASITEELL 199
            :.|.|..|.|.:|
Yeast   192 VEALIWQIVEPVL 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5757	NP_001261065.1	PLN02924	1..197	CDD:178512	88/204 (43%)
CG5757	NP_001261065.1	Thymidylate_kin	12..191	CDD:280400	82/192 (43%)
CDC8	NP_012591.1	NK	3..206	CDD:418433	90/208 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346591
Domainoid	1	1.000	148	1.000	Domainoid score	I964
eggNOG	1	0.900	-	-		E1_COG0125
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6285
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1084
Isobase	1	0.950	-	0	Normalized mean entropy	S1131
OMA	1	1.010	-	-		QHG54297
OrthoFinder	1	1.000	-	-		FOG0003433
OrthoInspector	1	1.000	-	-		oto100339
orthoMCL	1	0.900	-	-		OOG6_100714
Panther	1	1.100	-	-	LDO	PTHR10344
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R645
SonicParanoid	1	1.000	-	-		X2795
TreeFam	1	0.960	-	-
	16	15.740