DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10911 and AHNAK2

DIOPT Version :9

Sequence 1:	NP_611286.1	Gene:	CG10911 / 37058	FlyBaseID:	FBgn0034295	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_612429.2	Gene:	AHNAK2 / 113146	HGNCID:	20125	Length:	5795	Species:	Homo sapiens

Alignment Length:	268	Identity:	53/268 - (19%)
Similarity:	85/268 - (31%)	Gaps:	96/268 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 IAGAPIPSESTSTQASSTDSSTD-------STSASTESSTDSSSVSTESSTDS------------ 230
            |.||.:.|:..:..:..|....|       ||....||...:|.:.|.|...|
Human  5467 IQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSLLKVKIPEPHTQ 5531

  Fly   231 ----SSVSTESSTDSSTDSSSASTESSTDSSSVSTESSTDSSTD--SSSV-------------ST 276
                ::::..|.|...|:.:........||.|...:..|....:  ||||             |.
Human  5532 ARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSSVNVLGQQTLTFEVPSG 5596

  Fly   277 ESSTDSSTDSSSA---------STESSTESSSD--SPSDSTE-----------------SSTDSS 313
            ....||.:|...|         |.|::|..:.:  :|.|..|                 ||.|.:
Human  5597 HQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESKKSGLLWFWLPNIGFSSSVDET 5661

  Fly   314 SVSTE-----STTSSGEKEAAPEEDL-----------------------KSLSSQNSNDL--QKI 348
            .|.::     |.....:.||.||.:|                       ||.|:::..:|  ||:
Human  5662 GVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFPKLGFSSSPTKKSKSTEDGAELEEQKL 5726

  Fly   349 LKNLRVWF 356
            .:....:|
Human  5727 QEETITFF 5734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10911	NP_611286.1	DUF725	48..168	CDD:283039
AHNAK2	NP_612429.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..88
		PDZ_signaling	112..191	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..454
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..647
		TamB	763..>1397	CDD:225463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..956
		TIGR02099	<1521..>2153	CDD:273971
		TamB	1873..>2882	CDD:225463
		TamB	2923..>3712	CDD:225463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3071..3101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3235..3259
		TamB	3898..>4532	CDD:225463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4815..4848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4933..4958
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4993..5167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5324..5361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5537..5574		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5596..5639		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5659..5757		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	5769..5795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28UXN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900