DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc55B and Prg4

DIOPT Version :9

Sequence 1:	NP_001286561.1	Gene:	Muc55B / 37057	FlyBaseID:	FBgn0034294	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001099432.4	Gene:	Prg4 / 289104	RGDID:	1308976	Length:	1275	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	163/404 - (40%)
Similarity:	211/404 - (52%)	Gaps:	56/404 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 TNKMCSSLTECDTLVDGLEFFDCYRNASSDSYKVMFTLNSDSSLDFNRISAKYQVIETDLTDCVD 168
            |:|..||.:..:|.|:..|..:  .|..|.:.|...|.::..:......|||  .:|...|...:
  Rat   265 TSKEASSTSNKETTVETKETTE--TNKQSSASKKEKTTSAKETRSAENTSAK--DVEPTSTTPKN 325

  Fly   169 SARLDYAHDMDACDENLTLCLKGGE-TSPEPTVPTTTSGTPVTV-------------TTPEAPVS 219
            ||.......:....|.:....||.| ||.|| .|||.....:|:             |||:.|..
  Rat   326 SAPTTTKKPVTTTKEPVPTTTKGPEPTSKEP-APTTPKEPELTIPKEPAPTTKKPAPTTPKEPAP 389

  Fly   220 TTPEAPVTTTP--VAPSTTETPVPTTP--VAPSTTEAPVSTTPEAPVSTTPVAPS-TTEAPVPTT 279
            |||:.|..|||  .||:|.:.|.||||  .||:|.:.|..|||:.|..|||..|: ||:.|.|||
  Rat   390 TTPKEPEPTTPKESAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTKKPEPTT 454

  Fly   280 P--VAPSTTEAPVPTTP--VAPSTTEAPVPTTPVAPSTTEAPVPTTPVAPSTT--EAPVPTTP-- 336
            |  .||:|.:.|.||||  .||:|.:.|.||||      :.|.||||..|.:|  :.|.||||
  Rat   455 PKEPAPTTPKEPAPTTPKEPAPNTPKEPAPTTP------KEPAPTTPKEPESTTPKEPAPTTPKE 513

  Fly   337 VAPSTTEAPVPTTP--VAPSTTEAPVPTTP--VAPSTTEAPVPTTP--VAPSTTEAPVPTTPVAP 395
            .||:|.:.|.||||  .||:|.:.|.||||  .||:|.:.|.||||  .||:|.:.||||||..|
  Rat   514 PAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPVPTTPKEP 578

  Fly   396 STT--EAPVPTTP--VAPSTTEAPVPTTP--VASSTTEAPVSTTPVAPSTT----EAPVSSTPES 450
            ::|  :.|.||||  .||:|.:.|.||||  .|.:|.:.|..|||..|:.|    .||....||.
  Rat   579 ASTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPALTTPKEPAPTPKEPEP 643

  Fly   451 TT--EAASTTERSP 462
            ||  |.|.||.:.|
  Rat   644 TTPKEPAPTTPKEP 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc55B	NP_001286561.1	DUF725	52..170	CDD:283039	16/65 (25%)
Prg4	NP_001099432.4	SO	26..68	CDD:197571
		SO	67..108	CDD:197571
		PHA03247	<315..724	CDD:223021	149/350 (43%)
		HX	1013..1274	CDD:238046
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910