DRSC/TRiP Functional Genomics Resources

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Protein Alignment Muc55B and Cdhr5

DIOPT Version :9

Sequence 1:NP_001286561.1 Gene:Muc55B / 37057 FlyBaseID:FBgn0034294 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_612534.1 Gene:Cdhr5 / 171554 RGDID:620504 Length:862 Species:Rattus norvegicus


Alignment Length:447 Identity:114/447 - (25%)
Similarity:169/447 - (37%) Gaps:114/447 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 DDSTLINDCFNHYLEDQTNVIMGYN----LQYTGCLRTAQS--GRDELTKESASEREALLDRTNK 106
            ||:.:||       :|..|:.|..:    :.:|..:|..|:  .|..:|:.....|         
  Rat   300 DDTFIIN-------KDDGNLTMAKSIPSPMTFTLVVRAEQADMARYSVTQAVVEAR--------- 348

  Fly   107 MCSSLTECDTLVDGLEFFDCYRNASSDSYKVMFTLNSDSSL---------DFNRISAKYQVIETD 162
                    |...:.|:|       |...|.....|.|::..         :..||.|:|... .|
  Rat   349 --------DVTGNPLQF-------SQSLYFGTVVLGSEAGTAVKDKTFPSEILRIQAQYLGF-PD 397

  Fly   163 LTDCVDSARLDYAHDMDACDENLTLCLKGGETSPEPTVPTTTSGTPVTVTTPEAPVSTTPEAPVT 227
            |...|.....:.:..:...|..||            |||..|..| :.:   |...:.|....:.
  Rat   398 LNSAVTYQVTNSSEFIMNKDILLT------------TVPMETERT-IRI---EVEANNTVTKDIA 446

  Fly   228 TTPV-------APSTTETPVPTTPVAPSTTEAPVSTTPEAP-VSTTPVAPSTTEAPVPTTPVAPS 284
            ||.|       .|.:||:|.|  |.|..||....:||.|.| .|.|...|:||.:.....|..|:
  Rat   447 TTIVEIQVSEREPPSTESPTP--PEAGGTTGPSSNTTLETPSTSGTSQGPATTSSGGSAGPFPPA 509

  Fly   285 -TTEAPVPTTPVAP------STTEAPVPTTPVAPSTTEAPVPTTPVAPSTTEAPVPTTPVAPSTT 342
             ||.:|:.:.|..|      ..:.:|...||...:|      .|| .|.|::..|||    |..:
  Rat   510 GTTLSPLTSAPTVPGGSPTLGISTSPQTATPGGDAT------QTP-KPGTSQPMVPT----PGAS 563

  Fly   343 EAPVPTTPVAPSTTEAPVPTT--PVAPSTTEAPVPTTPVAPSTTEAPVPTTPVAPSTTEAPVPTT 405
            .:..|.|| :.|:|:.|.|.|  |:.| |..|...:.|..||.:....|    .|.|::..||| 
  Rat   564 TSSQPATP-SGSSTQTPKPGTSQPMVP-TPGASTSSQPATPSGSSTQTP----RPGTSQPMVPT- 621

  Fly   406 PVAPSTTEAPVPTTPVASSTTEAPVSTTPVAPSTTEAPVSSTPE-------STTEAA 455
               |..:.:..|.||..|:.|..|.::.|    ||..|:|...|       ||.:.|
  Rat   622 ---PGASTSSQPATPSGSTQTPKPGTSQP----TTTGPISGVGELGDGQRFSTVDMA 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Muc55BNP_001286561.1 DUF725 52..170 CDD:283039 25/132 (19%)
Cdhr5NP_612534.1 Cadherin_repeat 133..231 CDD:206637
Cadherin_repeat 255..353 CDD:206637 14/76 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..658 70/232 (30%)
Paramyxo_PNT <477..537 CDD:290537 17/59 (29%)
Cornifin 507..649 CDD:280537 47/166 (28%)
4 X 31 AA approximate tandem repeats 545..648 38/127 (30%)
ASFV_J13L <547..631 CDD:114299 30/98 (31%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9HBB8 693..862
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..803
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..862
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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