DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and KCNH7

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_011510411.1	Gene:	KCNH7 / 90134	HGNCID:	18863	Length:	1204	Species:	Homo sapiens

Alignment Length:	1288	Identity:	384/1288 - (29%)
Similarity:	588/1288 - (45%)	Gaps:	356/1288 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||||.||..:|:|.:..|::.||:.....|:||:|||.::||:||..:|||.|:
Human     1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||:||:||.....||.::|....|.|:||.:|.|.|:.|.|...|:|:||::...::|:.:.:
Human    66 CDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFE 130

  Fly   131 DITHTKMLEMNVN----EECDSVFALTAA---LLGARFRAGSNAGMLGLGGLPGLG--------- 179
            .:|.      |.|    |..:.:..:...   ..|.:|              |||.
Human   131 YVTD------NENAATPERVNPILPIKTVNRKFFGFKF--------------PGLRVLTYRKQSL 175

  Fly   180 ---------------------------------GPAASDGDTEAGEGNNLDVPAGCN-------- 203
                                             .|:.:| ||:|     |..|:.|:
Human   176 PQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEAD-DTKA-----LIQPSKCSPLVNISGP 234

  Fly   204 -----------------------MGRRRSRAVL---------YQLSG-----------HYKPEKG 225
                                   :...|||..|         :.:.|           .:..|..
Human   235 LDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDN 299

  Fly   226 GVKTKLK----LGNNFMH---------------------------------STE----------- 242
            |...|:.    .|..|.|                                 .||
Human   300 GRNVKVSRSWMAGGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDK 364

  Fly   243 ---AP-----------------------FPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYV 281
               ||                       .||||.|:.:.::..:.||..||.:|||:||:...|.
Human   365 TIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYT 429

  Fly   282 ALMVPYNAAFAKADRQTK-------------VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSK 333
            |:..||:|||...||:.:             |.|:||:.:||:|||:|||||:|::..||||:..
Human   430 AIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPA 494

  Fly   334 QIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMI 398
            :|||:|.:|||.:|::||:|||.|......|...:.|.|:|..|||||.|:.:|:||||::.|.:
Human   495 KIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV 559

  Fly   399 LTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWL----QLLAERKNASVAIL--TTAETYS 457
            |.|||..|.|.|||||||||.|...|..:..: .||||    |.:.:|.|.|.:..  :..:.|.
Human   560 LMLLMCIFALIAHWLACIWYAIGNVERPYLTD-KIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYV 623

  Fly   458 TALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKW 522
            |||||||:|||||||||||.||.:||:|:|.:||||:||:|.:||||:|||||:||..:.|..:.
Human   624 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 688

  Fly   523 RDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPI 586
            ..:|:|:..|.:|..|:||:|:|||.:|:.::|||:...|:.|||.|:.|:.:||::.:|| ...
Human   689 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKA 753

  Fly   587 FEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGS 651
            |..||:|||:.|::..||....||:.|:|.||.|..:|:|..||:|::|||:|||||||.|:.|.
Human   754 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGE 818

  Fly   652 DINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFAN 716
              .|||.|...                :|::|::|||||||..|....|:|||.:|||:...|..
Human   819 --MVHLYAKPG----------------KSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLT 865

  Fly   717 DIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDE---NREEAEEGGKGEKENG-GGPPSGASPL 777
            ::  :||.|||  :|:..:|:..|..: :.||.|.   .|.:.....:|||||. ..|...|..:
Human   866 NL--ELTFNLR--HESAKADLLRSQSM-NDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTI 925

  Fly   778 HNISNSPLH--------------------------ATRSPLLGMGS--------PRNQRLH--QR 806
            .:..:|..|                          ...||.:|..|        |.:.|:|  :|
Human   926 RHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHIDKR 990

  Fly   807 GRSLITLRETNKRHRTLNA--------ACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTL 863
            ..|...:.:.....|. ||        ..:|.|.::...| .|.:.:.|.....|:.|..|::.|
Human   991 SHSCKDITDMRSWERE-NAHPQPEDSSPSALQRAAWGISE-TESDLTYGEVEQRLDLLQEQLNRL 1053

  Fly   864 HQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGV 928
            .   :|::.:::..:..||:.|..           .|||.|:                      |
Human  1054 E---SQMTTDIQTILQLLQKQTTV-----------VPPAYSM----------------------V 1082

  Fly   929 LAAAE----LAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKT-MTSRSSQTDFYRIDF 988
            .|.:|    :..:.|:|.  ||.   .::...|.:.||:.|..::.:|: :.|:.|.:....::
Human  1083 TAGSEYQRPIIQLMRTSQ--PEA---SIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLN- 1141

  Fly   989 PTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQK--------QTLQISPLNTI 1033
                   .|:...:..||..:..:..|:.|.|:|        .:|..|.|:|:
Human  1142 -------TASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTV 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	38/95 (40%)
		PAS_3	41..129	CDD:285623	38/87 (44%)
		Ion_trans	285..516	CDD:278921	124/249 (50%)
		Ion_trans_2	<455..510	CDD:285168	39/54 (72%)
		Crp	583..>650	CDD:223736	33/67 (49%)
		CAP_ED	586..715	CDD:237999	54/128 (42%)
KCNH7	XP_011510411.1	PAS_9	29..134	CDD:290162	41/104 (39%)
		PAS	41..130	CDD:238075	38/88 (43%)
		Ion_trans	456..679	CDD:278921	115/223 (52%)
		Ion_trans_2	<622..676	CDD:285168	39/53 (74%)
		Crp	747..>884	CDD:223736	64/158 (41%)
		CAP_ED	753..864	CDD:237999	54/128 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750