DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Cnga1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_445949.2	Gene:	Cnga1 / 85259	RGDID:	621815	Length:	683	Species:	Rattus norvegicus

Alignment Length:	651	Identity:	150/651 - (23%)
Similarity:	277/651 - (42%)	Gaps:	113/651 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 PEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVP 286
            |||...|.|.|      ...:...|:.|.:..||..:::...|.....|.:.|.:...|...|:.
  Rat   117 PEKKKKKEKEK------EKKKEEKPKEKKEEEKKEVVVIDPSGNMYYNWLFCITLPVMYNWTMII 175

  Fly   287 YNAAFAKAD----RQTKVSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRG-WFAL 346
            ..|.|.:..    ....:.|.:.:.:::.|:.:..||.:: .:|.:|.:..::...|... .|.|
  Rat   176 ARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYL-EQGLLVKDKLKLIEKYKANLQFKL 239

  Fly   347 DLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHT-----AMILTLLMFSF 406
            |:|:.:|.|.||....::..:     ::|.||||::|:.:...|....|     ..|..|:|: .
  Rat   240 DVLSVIPTDLLYFKFGWNYPE-----IRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMY-I 298

  Fly   407 TLAAHWLACIWY----VIAVKEYEW-FPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTS 466
            .:..||.||::|    .|......| :|:.|......||.:             |..:||::..:
  Rat   299 VIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARK-------------YVYSLYWSTLT 350

  Fly   467 LTSVGFGNVSANT-----TAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLK 526
            ||::|      .|     .:|.||.::..|||.|:.|.:.||:.::|..|.:.|:.::|:...:|
  Rat   351 LTTIG------ETPPPVLDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIK 409

  Fly   527 DFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAA 590
            .::...|:.|::::|:..:|...|:....:|..|.||..|::||.::::::|.:.| ::.||...
  Rat   410 QYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADC 474

  Fly   591 SQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVV--AILGKGDLVGSDI 653
            ..|.|..|.|.::....:||:|:..|||....:|.:..|.:.|:.||.:.  .:|..|...| :|
  Rat   475 EAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFG-EI 538

  Fly   654 NVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDI 718
            ::             .|..|.....|.:::||::.|.||.|:....|:|.|..||:.:.......
  Rat   539 SI-------------LNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKG 590

  Fly   719 QHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNS 783
            :..|   :::|.    .||.    :.::..|.::.||.....:|..:
  Rat   591 RQIL---MKDGL----LDIN----IANLGSDPKDLEEKVTRMEGSVD------------------ 626

  Fly   784 PLHATR-SPLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEP----EPLEEE 843
             |..|| :.:|.......|:|.||         ..|..:.|......:..:.|||    ||.|..
  Rat   627 -LLQTRFARILAEYESMQQKLKQR---------LTKVEKFLKPLIETEFSALEEPGGESEPTESL 681

  Fly   844 Q 844
            |
  Rat   682 Q 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	58/250 (23%)
		Ion_trans_2	<455..510	CDD:285168	18/59 (31%)
		Crp	583..>650	CDD:223736	19/68 (28%)
		CAP_ED	586..715	CDD:237999	35/130 (27%)
Cnga1	NP_445949.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..144		8/32 (25%)
		Ion_trans	156..398	CDD:395416	62/267 (23%)
		P-helix. /evidence=ECO:0000250\|UniProtKB:Q00194	341..351		2/9 (22%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q00194	352..360		3/13 (23%)
		C-linker. /evidence=ECO:0000250\|UniProtKB:Q00194	393..475		20/81 (25%)
		CAP_ED	470..586	CDD:237999	35/129 (27%)
		Cyclic nucleotide-binding domain (CNBD). /evidence=ECO:0000250\|UniProtKB:Q00194	476..603		36/147 (24%)
		CLZ	586..655	CDD:406832	17/107 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840