DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Cnga3

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_008765264.1	Gene:	Cnga3 / 85257	RGDID:	70948	Length:	670	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	125/527 - (23%)
Similarity:	244/527 - (46%)	Gaps:	87/527 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 KKSRLIL-PHYGVFKGIWDWVILVA--TFYVALMVPYNAAFAKADRQ----TKVSDVIVEALFIV 311
            ||..::: |...::   :.|:..:|  .||...::...|.|.:...:    ..|.|...:||::|
  Rat   135 KKDPIVVDPSSNIY---YRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVV 196

  Fly   312 DILLNFRTTFVSRKGEVVSNSKQIAINYLRG-WFALDLLAALPFDHLYASDLYDGEDSHIHL--- 372
            |:|:..||.|: .:|.:|.::|::..:|.:. .|.||:|:.:|.|..|           :.|
  Rat   197 DMLVRARTGFL-EQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAY-----------LKLGMN 249

  Fly   373 ---VKLTRLLRLARLLQKIDRYSQHT-----AMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFP 429
               ::..||||.:||.:..||....|     ..|..|::::. :..||.|||::  |:.::..|.
  Rat   250 YPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTL-IIIHWNACIYF--AISKFIGFG 311

  Fly   430 ESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANT-----TAEKVFTIIM 489
            ..:  |:.....:....    ..:..|..:||::..:||::|      .|     ..|.:|.:|.
  Rat   312 TDS--WVYPNTSKPEYG----RLSRKYIYSLYWSTLTLTTIG------ETPPPVKDEEYLFVVID 364

  Fly   490 MLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSH 554
            .|:|.|:.|.:.|||.::|..|.:.|:.:::|...:|.::....:.|:|:.|:..:|...|:...
  Rat   365 FLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRK 429

  Fly   555 GIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGD 618
            .:|..|.|:..|::|:.::::::|.:.| ::.||:....|.|..|.|.::....:||:|:..|||
  Rat   430 TVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGD 494

  Fly   619 ALNYIYYLCNGSMEVIKDDMVV--AILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSS 681
            ....:|.:..|.:.|:.||.|.  .:|..|...|....:::..:.:|.              |.:
  Rat   495 IGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN--------------RRT 545

  Fly   682 SDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFA----------NDIQHDLTC------NLREGY 730
            ::|:::.|.||.|:....|:|.|..||:.::...          |.|..||..      |:.|..
  Rat   546 ANIRSIGYSDLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKV 610

  Fly   731 ENQDSDI 737
            |..:|.:
  Rat   611 EYLESSL 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	62/251 (25%)
		Ion_trans_2	<455..510	CDD:285168	18/59 (31%)
		Crp	583..>650	CDD:223736	20/68 (29%)
		CAP_ED	586..715	CDD:237999	33/130 (25%)
Cnga3	XP_008765264.1	Ion_trans	166..390	CDD:278921	62/250 (25%)
		Radical_SAM	423..>476	CDD:302752	13/52 (25%)
		Crp	456..>578	CDD:223736	34/135 (25%)
		CAP_ED	462..578	CDD:237999	33/129 (26%)
		CLZ	578..648	CDD:293134	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840