DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Cngb1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_113997.2	Gene:	Cngb1 / 83686	RGDID:	621809	Length:	1338	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	186/962 - (19%)
Similarity:	342/962 - (35%)	Gaps:	259/962 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTK 136
            |.|||..:.|:|.:.:....|..|......|..|      :.|.|::.      ||.....||.|
  Rat   556 PATKEHPELQVEDTDAEAGPLIPEETIPPPERPP------VSPAKSDT------LAVPGAATHRK 608

  Fly   137 MLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGNNLDVPAG 201
            .|. :.::|.:.:.||:.|  .:...|.|:...           |..:||:..|..      .|.
  Rat   609 KLP-SQDDEAEELKALSPA--ESPVVAWSDPTT-----------PQEADGEDRAAS------TAS 653

  Fly   202 CNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFP-------------------- 246
            .|......|  |.:|...:|.....||.|| :..:.....|:|.|
  Rat   654 QNSAIINDR--LQELVKMFKERTEKVKEKL-IDPDVTSDEESPKPSPAKKAPDSAPAQKPAEAEA 715

  Fly   247 ------------EYKTQSIKKSRL---ILPHYGVFKGIWDWVILVATFYVALMVPYNAAF--AKA 294
                        ::|.:..|..:.   |.|...:...:|.:.:::|..:...::|...||  .:|
  Rat   716 AEEEHYCDMLCCKFKRRPWKMYQFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRA 780

  Fly   295 D--RQTKVSDVIVEALFIVDI-LLNFRTTFVSRKGEVVSNSKQIAINYLRGW-FALDLLAALPFD 355
            |  ....:.|.:.:.::::|| :...|..|| :.|:::::.|::..|||:.. |.:|||..||.|
  Rat   781 DNIHLWLLMDYLCDFIYLLDITVFQMRLQFV-KGGDIITDKKEMRNNYLKSQRFKMDLLCLLPLD 844

  Fly   356 HLYASDLYDGEDSHIHLVKLTRLL----------RLARLLQK--IDRYSQHTAMILTLLMFSFTL 408
            .||   |..|.:.   |::|.|.|          ||..:|.|  :.|..:.||.:|..|
  Rat   845 FLY---LKLGVNP---LLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSL------ 897

  Fly   409 AAHWLACIWYVIA----VKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTS 469
              |..:|::|..:    :....|..:.                    ...:|....|:...:|.:
  Rat   898 --HLNSCLYYWASAFQGIGSTHWVYDG--------------------VGNSYIRCYYWAVKTLIT 940

  Fly   470 VGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNM 534
            :| |.....|..|.||.::....|....:|:.|.:..::....:.::.|.|.......::..:.:
  Rat   941 IG-GLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKI 1004

  Fly   535 PKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLL 598
            |:.::.|::.:::.:|.....:|..|.:.:.|:::|.|:::.::..|: ::.:|:...:..:..:
  Rat  1005 PRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDM 1069

  Fly   599 SLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVI---KDDMVVAILGKGDLVGSDINVHLVAT 660
            ...:::....|.:|:..||:....:|.:..|.::|:   ....|:..|..|.:.|   .:.|:|.
  Rat  1070 LKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFG---EISLLAV 1131

  Fly   661 SNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCN 725
            ..|.              |.::::.|..:.:|..:....|.|:|..|||.|:......:..|..|
  Rat  1132 GGGN--------------RRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNN 1182

  Fly   726 LREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRS 790
            .:.                                |.||.....||...:|  .:.|:.|.|.
  Rat  1183 NKP--------------------------------KEEKSVLILPPRAGTP--KLFNAALAAA-- 1211

  Fly   791 PLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSS---GGKRPS 852
               |...||.    .:|..|..||...|....|.||.       .:.:.||:.:||   ||:..|
  Rat  1212 ---GKMGPRG----AKGGKLAHLRARLKELAALEAAA-------RQQQLLEQAKSSQEAGGEEGS 1262

  Fly   853 LERLDSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSG 917
                    ....|...|..:|.:....                    |||.|.|
  Rat  1263 --------GATDQPAPQEPSEPKEPPE--------------------PPAPSSP----------- 1288

  Fly   918 VAVEHGLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVE 969
                      ..|:|:.......::.|||        |:.....|..|.|.|
  Rat  1289 ----------PPASAKPEGSTEEAAGPPE--------PSVRIRVSPGPDPGE 1322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	14/59 (24%)
		PAS_3	41..129	CDD:285623	14/56 (25%)
		Ion_trans	285..516	CDD:278921	56/252 (22%)
		Ion_trans_2	<455..510	CDD:285168	12/54 (22%)
		Crp	583..>650	CDD:223736	11/69 (16%)
		CAP_ED	586..715	CDD:237999	25/131 (19%)
Cngb1	NP_113997.2	PLN03192	743..>1129	CDD:215625	83/424 (20%)
Cngb1	NP_113997.2	CAP_ED	1057..1166	CDD:237999	22/125 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840