DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and KT1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_180233.1	Gene:	KT1 / 817206	AraportID:	AT2G26650	Length:	857	Species:	Arabidopsis thaliana

Alignment Length:	898	Identity:	185/898 - (20%)
Similarity:	346/898 - (38%)	Gaps:	192/898 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 IKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADR-QTKVSDVIVEALFIVDILLN 316
            :|..|.::..|.....||:..::|...|.|.:.|:...|.:..| ...::|.||.|.|.:||::.
plant    43 VKLRRFVVSPYDHKYRIWEAFLVVLVVYTAWVSPFEFGFLRKPRPPLSITDNIVNAFFAIDIIMT 107

  Fly   317 F------RTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHL--YASDLYDGEDSHIHLV 373
            |      ::|::     :|.:.||||..|||.||.|||::.:|.:..  .:|..|    ...:::
plant   108 FFVGYLDKSTYL-----IVDDRKQIAFKYLRSWFLLDLVSTIPSEAAMRISSQSY----GLFNML 163

  Fly   374 KLTRLLRLARLLQKIDR------YSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE----W- 427
            :|.||.|:..|..::::      :....|.::.:.:|    |.|..||.:|:||.:...    |
plant   164 RLWRLRRVGALFARLEKDRNFNYFWVRCAKLVCVTLF----AVHCAACFYYLIAARNSNPAKTWI 224

  Fly   428 ------FPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFT 486
                  |.|.:: |::                  |.|::|::.|:||:||:|::....|.|.:|.
plant   225 GANVANFLEESL-WMR------------------YVTSMYWSITTLTTVGYGDLHPVNTKEMIFD 270

  Fly   487 IIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDY----FQ 547
            |..||....:.|.:.||:|.::....||...:....:...:|...:::|..|:.::..:    ::
plant   271 IFYMLFNLGLTAYLIGNMTNLVVHGTSRTRNFRDTIQAASNFAHRNHLPPRLQDQMLAHLCLKYR 335

  Fly   548 TSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGE 611
            |.   |.|:...|||...|:.:|..:|..|...:: ::.:|...|...|..|...:|..:..|.|
plant   336 TD---SEGLQQQETLDALPKAIRSSISHFLFYSLMDKVYLFRGVSNDLLFQLVSEMKAEYFPPKE 397

  Fly   612 YLIHKGDALNYIYYLCNGSMEVIKDD----MVVAILGKGDLVGSDINVHLVATSNGQMTATTNSA 672
            .:|.:.:|....|.|.||:.:::..|    .:|..:..||::|   .:.::.......|..|...
plant   398 DVILQNEAPTDFYILVNGTADLVDVDTGTESIVREVKAGDIIG---EIGVLCYRPQLFTVRTKRL 459

  Fly   673 GQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDI 737
            .|  ::|    :...|:.::...::|....::....::.::..:.:..::...:.........|:
plant   460 CQ--LLR----MNRTTFLNIIQANVGDGTIIMNNLLQHLKEMNDPVMTNVLLEIENMLARGKMDL 518

  Fly   738 GPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRNQR 802
            ..:....:|.|||....:..:.|....|:..   :|.:|||      :.|::..|
plant   519 PLNLCFAAIREDDLLLHQLLKRGLDPNESDN---NGRTPLH------IAASKGTL---------- 564

  Fly   803 LHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLHQDV 867
                 ..::.|.|   .|...|  |....||.    ||.|....|.::.....|:...:....||
plant   565 -----NCVLLLLE---YHADPN--CRDAEGSV----PLWEAMVEGHEKVVKVLLEHGSTIDAGDV 615

  Fly   868 ---AQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVE-------- 921
               |..:||..| :..|:|:......:|.            |..:|.:...:.|..|
plant   616 GHFACTAAEQGN-LKLLKEIVLHGGDVTR------------PRATGTSALHTAVCEENIEMVKYL 667

  Fly   922 ------------HGLMGGVLAA----AELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPV-- 968
                        ||.....||.    .::.|:.|...|.     |.|.:.||::.      |:
plant   668 LEQGADVNKQDMHGWTPRDLAEQQGHEDIKALFREKLHE-----RRVHIETSSSV------PILK 721

  Fly   969 -----------EPKKTMTSRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQK 1022
                       ||.....||...   :||......|........:.|:|..:...||.:..:.:.
plant   722 TGIRFLGRFTSEPNIRPASREVS---FRIRETRARRKTNNFDNSLFGILANQSVPKNGLATVDEG 783

  Fly  1023 QTLQISPLNTIDECVSPSDHNLASSKERLITSSAVPTPGRIYPPLDDENSNDF 1075
            :|  .:|:.....|....|          |....|..||. :..|.:..||.|
plant   784 RT--GNPVRVTISCAEKDD----------IAGKLVLLPGS-FKELLELGSNKF 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	67/256 (26%)
		Ion_trans_2	<455..510	CDD:285168	19/54 (35%)
		Crp	583..>650	CDD:223736	17/70 (24%)
		CAP_ED	586..715	CDD:237999	24/132 (18%)
KT1	NP_180233.1	PLN03192	26..856	CDD:215625	185/898 (21%)
		Ion_trans_2	<240..294	CDD:285168	19/53 (36%)
		CAP_ED	372..477	CDD:237999	23/113 (20%)
		ANK repeat	522..548	CDD:293786	6/25 (24%)
		ANK	545..696	CDD:238125	36/196 (18%)
		ANK repeat	550..581	CDD:293786	11/56 (20%)
		ANK repeat	583..614	CDD:293786	7/34 (21%)
		ANK repeat	647..678	CDD:293786	3/30 (10%)
		KHA	790..853	CDD:288667	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I2073
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8395
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810