DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and SPIK

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_180131.3	Gene:	SPIK / 817099	AraportID:	AT2G25600	Length:	888	Species:	Arabidopsis thaliana

Alignment Length:	839	Identity:	172/839 - (20%)
Similarity:	316/839 - (37%)	Gaps:	183/839 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 GLGGPAASDGDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHST 241
            |.||.....|.|:..|.:..|     ::.|..:.: .|.||....|         .||.|...|.
plant    15 GEGGGGRGGGRTKDAEDDVAD-----HLSRDGTMS-QYSLSKGLLP---------SLGANNRSSR 64

  Fly   242 EAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADR-QTKVSDVIV 305
            :...|.:......      |.|..    |:..::....|.|...|:...|.:..| ...:.|.||
plant    65 DVILPRFIVSPFD------PRYRA----WETFLVFLVLYTAWASPFEFGFLQKPRPPLSILDNIV 119

  Fly   306 EALFIVDILLNFRTTFVSRKGE-VVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSH 369
            ...|.|||:|.|...|:.:... :|.:.|:||..|...|...|:::..|:: ::.|.|::....:
plant   120 NGFFAVDIVLTFFVAFLDKVTYLLVDDPKRIAWRYASTWLIFDVVSTFPYE-IFGSLLHESIQGY 183

  Fly   370 IHLVKLTRLLRLARL------LQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWF 428
             .:..:.||.||.|:      |:|..:||........||:.:. ...|..||..|.||..    :
plant   184 -GIFSMLRLWRLRRVSNCFARLEKDRKYSYFWVRCSKLLLVTL-FVIHCGACFLYSIAAH----Y 242

  Fly   429 PESNIGWLQLLAER-KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLI 492
            |:.:..::.|..|. |.:.:|:     .|:||:|::.|:.::.|:|::....:.|..|.:..|:.
plant   243 PDPSKTFMALTDENWKESPIAV-----RYNTAMYWSITTFSTTGYGDIHGVNSREMTFILFYMVF 302

  Fly   493 GALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDY----FQTSWSLS 553
            ...:.|.:.||:|.::..:..|...:....:....|...:|:|..|:.::..:    ::|.   |
plant   303 NLGLSAYIIGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNLPVRLQDQMVAHLCLRYRTD---S 364

  Fly   554 HGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKG 617
            .|:...|.:...|:.:|..:|.:|..|:: ::.:|...|...|..|...:|..:..|.|.:|.:.
plant   365 EGLQQQEIIDSLPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQLVTEMKAEYFPPKEDVILQN 429

  Fly   618 DALNYIYYLCNGSMEVIKD----DMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQ---- 674
            :|....|.|..|::::|..    :.||:...:|.:.|   .|.::.......|..|....|
plant   430 EAPTDFYILVTGAVDIIARVNGVEQVVSEAQRGHVFG---EVGVLCYRPQLFTVRTKRLSQLLRL 491

  Fly   675 ------DVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQ 733
                  ::|..:..|         ..|.|..|::.|:   :.:......:..|....|.:|
plant   492 NRTVLLNLVQANVGD---------GAIIMNNLLQHLK---DSEDPVMKGVLADTEHMLAQG---- 540

  Fly   734 DSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSP 798
            ..|:..|....:...||                        ..||.            ||..||.
plant   541 KMDLPLSLCFAAARGDD------------------------LLLHQ------------LLRRGSS 569

  Fly   799 RNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTL 863
            .|: :.:.||:.:.:..:...|..:  ...|:.|:  :|...:.|    |..|..|.:..:
plant   570 PNE-MDKDGRTALHIAASKGSHYCV--VLLLEHGA--DPNIRDSE----GNVPLWEAIIGR---- 621

  Fly   864 HQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGV 928
            |:::|:|.||              :.|..|..|:.:               .||:|||...:..:
plant   622 HREIAKLLAE--------------NGAKLSLDSVSY---------------FSGLAVEKNCLDAL 657

  Fly   929 LAAAELAAMQRSSSHPPEVWGRDVQLPTSN--TASSKAPSP--VEPKKTMTSRSSQTDF 983
            ....:              :|.||.||..|  ||..:|.|.  :|..|.:..:.:..|:
plant   658 KDIIK--------------YGGDVTLPDGNGTTALHRAVSEGHLEIVKFLLDQGADLDW 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	60/239 (25%)
		Ion_trans_2	<455..510	CDD:285168	14/54 (26%)
		Crp	583..>650	CDD:223736	16/70 (23%)
		CAP_ED	586..715	CDD:237999	27/142 (19%)
SPIK	NP_180131.3	PLN03192	38..888	CDD:215625	165/811 (20%)
		ANK repeat	548..574	CDD:293786	9/62 (15%)
		ANK repeat	576..607	CDD:293786	6/34 (18%)
		ANK repeat	609..671	CDD:293786	21/112 (19%)
		ANK repeat	673..704	CDD:293786	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I2073
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8395
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810