Protein Alignment Elk and KCNH6

DIOPT Version :9

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_110406.1
• Gene: KCNH6 / 81033
• HGNCID: 18862
• Length: 994
• Species: Homo sapiens
• Alignment Length: 1058
• Identity: 369/1058 - (34%)
• Similarity: 558/1058 - (52%)
• Gaps: 174/1058 - (16%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||:||||..:|:|....|::.|||.....|:||:|||.:|.||||.::||:.|:
Human     1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||.||:|......::.::|....|.|:::::|:|:.:.|.||.|:||:|||...|::|:.:.:
Human    66 CDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGNN 195
            |:.       .:..:|.| .:|:..||...|     .|..|..|.||..||.     |..|:...
Human   131 DLA-------QLLAKCSS-RSLSQRLLSQSF-----LGSEGSHGRPGGPGPG-----TGRGKYRT 177

  Fly   196 L-DVP------AGCNMGRRRSRAV--LYQLSGHYKPEKGGVKTK-----LKLGNNFMHSTEAPFP 246
            : .:|      ...|:.:.||.:.  :..::.|...|:....|:     |.||.:.:       |
Human   178 ISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL-------P 235

  Fly   247 EYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK------------ 299
            |||.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||..:|:...
Human   236 EYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300

  Fly   300 -VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLY 363
             |.|:||:.:|:|||::|||||:|:...||||:.::||::|.:|||.:|::||:|||.|......
Human   301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGS 365

  Fly   364 DGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWF 428
            |...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|..:.
Human   366 DETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYL 430

  Fly   429 PESNIGWLQ----LLAERKNAS--VAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTI 487
             |..||||.    .|.:|.|.|  .:..:..:.|.|||||||:|||||||||||.||.:||||:|
Human   431 -EHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSI 494

  Fly   488 IMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSL 552
            .:||||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|..|:||:|:|||.:||.
Human   495 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSY 559

  Fly   553 SHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHK 616
            ::|||:...|:.|||.|:.|:.:||||.:|| .|.|..|.:|||:.|::..||....||:.|:|.
Human   560 TNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHL 624

  Fly   617 GDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSS 681
            ||.|:.:|::..||:|:::||:|||||||.|:.|..:::|.             ..|     :||
Human   625 GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHA-------------QPG-----KSS 671

  Fly   682 SDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLR------------------- 727
            :|::|||||||..|....|:|||.:||.:.:.|.:.:  ::|.|||
Human   672 ADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKL--EVTFNLRDAAGGLHSSPRQAPGSQDH 734

  Fly   728 EGY---ENQDS---DIGPSFPLPSISEDDENREEAEEGGKGEKENGGGP-----PSGASPLHNIS 781
            :|:   :||..   ::||.||         ::..:..|...:...|.||     |..|.|| :||
Human   735 QGFFLSDNQSGSPHELGPQFP---------SKGYSLLGPGSQNSMGAGPCAPGHPDAAPPL-SIS 789

  Fly   782 NS------------PLHATRSPL-------LGMGSPRNQ------RLHQR-----GRSLITLRET 816
            ::            |.|:.:||.       |.:||...|      ||..|     .|.|..|::.
Human   790 DASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKP 854

  Fly   817 NKR-HRT--LNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLHQDVAQLSAEVRNAI 878
            ..: |.:  |.|..|.|....    |:..|.:|.|.|.....|....:..:.|:...|.:.||:.
Human   855 MPQGHASYILEAPASNDLALV----PIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSS 915

  Fly   879 SALQEMTFTSNAMTSHSSLK------FPPARSIPNISGVAGTRSGVAV----EHGLMGGVLAAAE 933
            ..:..:...::...:.||.:      :||..|..:...|.|...|...    ||  :|.|....:
Human   916 PRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEH--LGSVPKQLD 978

  Fly   934 LAAMQRSSSHP--PEVWG 949
               .||..|.|  ...||
Human   979 ---FQRHGSDPGFAGSWG 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	36/95 (38%)
		PAS_3	41..129	CDD:285623	36/87 (41%)
		Ion_trans	285..516	CDD:278921	123/249 (49%)
		Ion_trans_2	<455..510	CDD:285168	40/54 (74%)
		Crp	583..>650	CDD:223736	31/67 (46%)
		CAP_ED	586..715	CDD:237999	49/128 (38%)
KCNH6	NP_110406.1	PAS_9	29..132	CDD:290162	40/102 (39%)
		PAS	41..132	CDD:238075	36/90 (40%)
		Ion_trans	296..520	CDD:278921	115/224 (51%)
		Ion_trans_2	<463..517	CDD:285168	40/53 (75%)
		Selectivity filter. /evidence=ECO:0000250	476..481		4/4 (100%)
		Crp	588..>704	CDD:223736	52/133 (39%)
		CAP_ED	594..705	CDD:237999	49/128 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..790		16/79 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	880..946		13/65 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820