Protein Alignment Elk and HCN2

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_001185.3
• Gene: HCN2 / 610
• HGNCID: 4846
• Length: 889
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 183/802 - (22%)
• Similarity: 323/802 - (40%)
• Gaps: 184/802 - (22%)

  Fly   173 GGLPGLGGPAASDGDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNF 237
            |..|| .|||...|..|||       |||...|.:.| .:..|.....:|   ||.   |.....
Human   133 GPAPG-PGPAEEAGSEEAG-------PAGEPRGSQAS-FMQRQFGALLQP---GVN---KFSLRM 182

  Fly   238 MHSTEAPFPEYKTQSIKKSRLILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK-- 299
            ..|.:|  .|.:.:.:|.:...:.| |..|:..||:.:|:......:::|....|.| |..|.
Human   183 FGSQKA--VEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFK-DETTAPW 244

  Fly   300 -VSDVIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDL 362
             |.:|:.:..|::|::|||||..|.... |::.:.::|...|||.||.:|.::::|.|:::.. :
Human   245 IVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLI-V 308

  Fly   363 YDGEDSHIH-------------LVKLTRLLRLARLLQKIDRYSQ---------HTAMILTLLMFS 405
            ..|.||.::             ::.|.|||||:||::.|.::.:         ...|.:..|:..
Human   309 EKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISM 373

  Fly   406 FTLAAHWLACIWYVIAVKEYEWFPES---------NIGWLQLLAERKNASVAILTTAETYSTALY 461
            ..|..||..|:.:::.:  .:.||.:         |..|                 :|.||.||:
Human   374 MLLLCHWDGCLQFLVPM--LQDFPRNCWVSINGMVNHSW-----------------SELYSFALF 419

  Fly   462 FTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLK 526
            ...:.:..:|:|..:..:..:...|::.|::||..:|:..|:.||:||.:.|.|..|:.|::.::
Human   420 KAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVE 484

  Fly   527 DFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-VSMHLHREILQLPIFEAA 590
            .:::.|.:|.:.:|:|.||::..:. ....|....|.|....||.: |:.:..:.:..:|:|..|
Human   485 QYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANA 548

  Fly   591 SQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINV 655
            ....:..:...:|.....||:|:|.:|.....:|::.:|         ||::|.||
Human   549 DPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHG---------VVSVLTKG--------- 595

  Fly   656 HLVATSNGQMTATTNSAGQDVVV----RSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQF-- 714
                  |.:|..:..|...::.:    |.::.::|.|||.|..:.:....|||..||..::.|
Human   596 ------NKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 654

  Fly   715 ----------------ANDIQHDLTCNLREGYEN--------------QDSDIG-------PSFP 742
                            .:.:||||...:....||              |.:::|       |..|
Human   655 VAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPP 719

  Fly   743 LPSISEDDENREEA---------------------------EEGGKGEKENGGGPPSGASPLHNI 780
            .|.::......::|                           ...|........|||..||| ...
Human   720 PPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP-PGA 783

  Fly   781 SNSPLHATR---------SPLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEE 836
            ..|| .|.|         :||.|...|. :||.:..|.| :..:.:..|.....|.|....|...
Human   784 PASP-RAPRTSPYGGLPAAPLAGPALPA-RRLSRASRPL-SASQPSLPHGAPGPAASTRPASSST 845

  Fly   837 PEPLEEEQSSGGKRPSLERLDS 858
            |. |....::....||.:|.||
Human   846 PR-LGPTPAARAAAPSPDRRDS 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873
		PLN03192	270..>650	CDD:215625	99/415 (24%)
		cNMP	586..716	CDD:197516	30/151 (20%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..159		14/33 (42%)
		PBP1	<57..185	CDD:444064	20/66 (30%)
		PLN03192	150..>688	CDD:215625	136/599 (23%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		12/59 (20%)
		CAP_ED	544..652	CDD:237999	29/131 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..889		30/118 (25%)