DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and HCN3

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_065948.1	Gene:	HCN3 / 57657	HGNCID:	19183	Length:	774	Species:	Homo sapiens

Alignment Length:	886	Identity:	199/886 - (22%)
Similarity:	347/886 - (39%)	Gaps:	214/886 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 AGSNAGML-GLGGLPGLGGPAASDGDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGG 226
            ||::.|.. ||..:|.:..|.|:     |..|   .:|......:||....|.|.:.:
Human     9 AGASEGATPGLEAVPPVAPPPAT-----AASG---PIPKSGPEPKRRHLGTLLQPTVN------- 58

  Fly   227 VKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRL------ILPHYGVFKGIWDWVILVATFYVALMV 285
             |..|::           |..:|...|::.|:      |:..|..|:..||.::|:......:::
Human    59 -KFSLRV-----------FGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVL 111

  Fly   286 PYNAAFAKADRQTK--VSDVIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALD 347
            |....|.|.:....  |.:|:.:..|::|::|||||..|..:| |::...:.|...|||.||.:|
Human   112 PVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVD 176

  Fly   348 LLAALPFDHLY-ASDLYDGEDSHIH-------------LVKLTRLLRLARLLQKIDRYSQHTAMI 398
            |::::|.|::: ..:|....|:.::             ::.|.|||||:||::.|.::.:...|.
Human   177 LISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMT 241

  Fly   399 LTL---------LMFSFTLAAHWLACIWYVIAVKEYEWFPES---------NIGWLQLLAERKNA 445
            ..|         |:....|..||..|:.:::.:  .:.||..         |..|
Human   242 YDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPM--LQDFPPDCWVSINHMVNHSW---------- 294

  Fly   446 SVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQR 510
                   ...||.||:...:.:..:|:|..:.....:...|::.|::||..:|:..|:.||:||.
Human   295 -------GRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQS 352

  Fly   511 MYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEE-LRGDVS 574
            :.|.|..|:.|::.::.:::.|.:|.:.:|||.:|::..:   .|       :.|.|| :.|::|
Human   353 LDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY---QG-------KMFDEESILGELS 407

  Fly   575 MHLHREIL---------QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGS 630
            ..|..||:         .:|:|..|....:..:...::.....||:.::.:|.....:|::.:|.
Human   408 EPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGL 472

  Fly   631 MEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCI 695
            :.|:........|..|...|     .:...:.|:.||:               ::|.|||.|..:
Human   473 LSVLARGARDTRLTDGSYFG-----EICLLTRGRRTAS---------------VRADTYCRLYSL 517

  Fly   696 HMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGG 760
            .:.....||..:|..::.|.......|   ||.|.:|.......|.|.|..|           ||
Human   518 SVDHFNAVLEEFPMMRRAFETVAMDRL---LRIGKKNSILQRKRSEPSPGSS-----------GG 568

  Fly   761 KGEKE------------NGGGPPSGASPLHNISNSP------LHATRSPLLGMGSPRNQRL---H 804
            ..|:.            .|..|.:||    .:|..|      :||   ||.......|..:   |
Human   569 IMEQHLVQHDRDMARGVRGRAPSTGA----QLSGKPVLWEPLVHA---PLQAAAVTSNVAIALTH 626

  Fly   805 QRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDS-QVSTLHQDVA 868
            |||    .|..:.....|| .|.|..|.:.....||...::  |...|..||.: ...|||   |
Human   627 QRG----PLPLSPDSPATL-LARSAWRSAGSPASPLVPVRA--GPWASTSRLPAPPARTLH---A 681

  Fly   869 QLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVLAAAE 933
            .||...|:.:|.|.                 ||       .|..|.|.|.      .|..|:|::
Human   682 SLSRAGRSQVSLLG-----------------PP-------PGGGGRRLGP------RGRPLSASQ 716

  Fly   934 LAAMQRSS--SHPPEVWGRDVQLPTSNTASSKAPSPVEPKK 972
            .:..||::  ..|........:||.|... :|.|...:|.:
Human   717 PSLPQRATGDGSPGRKGSGSERLPPSGLL-AKPPRTAQPPR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	64/265 (24%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	11/66 (17%)
		CAP_ED	586..715	CDD:237999	22/128 (17%)
HCN3	NP_065948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		12/46 (26%)
		Involved in subunit assembly. /evidence=ECO:0000250	46..91		12/63 (19%)
		Ion_trans_N	49..91	CDD:285597	10/60 (17%)
		Ion_trans	111..358	CDD:278921	64/265 (24%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	354..774		109/495 (22%)
		Crp	422..>560	CDD:223736	29/160 (18%)
		CAP_ED	428..536	CDD:237999	22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..774		23/106 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740