DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and kcnh6b

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_021328182.1	Gene:	kcnh6b / 570070	ZFINID:	ZDB-GENE-121214-55	Length:	893	Species:	Danio rerio

Alignment Length:	931	Identity:	301/931 - (32%)
Similarity:	447/931 - (48%)	Gaps:	196/931 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 LKLGNNFMHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD 295
            |.||.:.:       ||||.|:....:.|:.||..||.|||||||:...|.|:..|::|||...:
Zfish    72 LSLGADVL-------PEYKLQAPDVHKWIMLHYSPFKAIWDWVILLLVLYTAVFTPFSAAFLLNE 129

  Fly   296 -----RQT--------KVSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALD 347
                 |||        .|.||||:.|||.||::.||||:|:...|||::.|:|||:|::|||.:|
Zfish   130 LEDERRQTCGYTCNPLNVVDVIVDVLFIADIVITFRTTYVNHNDEVVTHPKRIAIHYIKGWFFID 194

  Fly   348 LLAALPFDHL-YASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAH 411
            ::||:|||.| :.|...:...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.||
Zfish   195 MVAAIPFDLLIFRSGSDETTATLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFGLIAH 259

  Fly   412 WLACIWYVIAVKEYEWFPESNIGWLQLLAE----RKNASVAIL--TTAETYSTALYFTFTSLTSV 470
            |||||||.|...|.   |....|||..||:    |.|.|.|..  :..:.|.|||||||:|||||
Zfish   260 WLACIWYAIGHVER---PYMKTGWLDNLADQLGKRYNDSDASSGPSIQDKYITALYFTFSSLTSV 321

  Fly   471 GFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMP 535
            ||||||.||.:||:|:|.:|.||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|
Zfish   322 GFGNVSPNTNSEKMFSICVMFIGSLMYASIFGNVSAIIQRLYSGTTRYHTQMLRVKEFIRFHQIP 386

  Fly   536 KELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLS 599
            ..|:||:|:|||.:||.::|||:...|:.|||.|:.|:.:||:|.:|| ..:|..||:.||:.|:
Zfish   387 GGLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQNCKVFRGASKACLRALA 451

  Fly   600 LHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQ 664
            :..::....||:.|.|:||.|..::::..||::|.:.::|:|||||.|:.|..:|::.
Zfish   452 VRFRSTHSPPGDALYHQGDMLRALHFISRGSIQVSQHNIVLAILGKNDVFGEPVNLYA------- 509

  Fly   665 MTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREG 729
                  ..|     .|::|:.|||||||..|....|:|||.:||.:.:.|..::  ::|.|||
Zfish   510 ------EPG-----HSNADVTALTYCDLHRIRRDDLLEVLDMYPAFGESFWRNL--EITFNLR-- 559

  Fly   730 YENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLG 794
                  |:....|..|:....:.|         .::|          |.:..|.|        .|
Zfish   560 ------DVEQMMPSESLECSYQAR---------HRQN----------LLDRRNRP--------DG 591

  Fly   795 MGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQ 859
            |....:.||    .|.:.|...:..|....||..:   .:|:......:|||       |.|.
Zfish   592 MDQNDSSRL----CSALGLHHHHHHHHHHPAAAHM---HWEDLCSYSTQQSS-------ENLS-- 640

  Fly   860 VSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGL 924
                |.::.                  ||:  |.|.....|..|.||      .:.|||:.|.|:
Zfish   641 ----HCELC------------------TSD--TEHLDYPSPAGRLIP------PSASGVSREIGV 675

  Fly   925 MGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDFP 989
                    |:..|.|..|.....|      |..:|... :..|:.|....||           ||
Zfish   676 --------EMGYMARPPSGLYHYW------PDPHTPHF-SDQPLRPPSIQTS-----------FP 714

  Fly   990 TFERFVLANPRLV---LGLL-----GIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDH---- 1042
            . :.|....|..|   |.||     .:|..:..:::::.|....|::|:......|.|..|
Zfish   715 P-QIFADHQPGEVEARLDLLHSQLNRLETRMTTDINVILQLLQRQMAPVPPAYSTVLPDRHPPDP 778

  Fly  1043 ------------------NLASSKERLITSSAVPTPGRIYPPLDDENSNDFRWTMKH-SASHHSC 1088
                              |:.......|.|||.|      ..:...||.....:..| .|:...|
Zfish   779 TALYRNNTPVLHSLYPIPNIQLDTNTAIQSSAQP------ESMFKANSQGSLSSGVHMGAASDDC 837

  Fly  1089 CKSTDALLSPEEQPPISILPV 1109
            ...|.::.:|..||.:...|:
Zfish   838 VPETTSVSTPALQPALMDAPM 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	125/250 (50%)
		Ion_trans_2	<455..510	CDD:285168	38/54 (70%)
		Crp	583..>650	CDD:223736	24/67 (36%)
		CAP_ED	586..715	CDD:237999	42/128 (33%)
kcnh6b	XP_021328182.1	Ion_trans	103..364	CDD:306908	132/263 (50%)
		CAP_ED	438..549	CDD:237999	42/128 (33%)
		PAT1	<681..>831	CDD:330585	33/174 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920