DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and cngb1a

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_696619.6	Gene:	cngb1a / 568211	ZFINID:	ZDB-GENE-050419-164	Length:	1326	Species:	Danio rerio

Alignment Length:	655	Identity:	137/655 - (20%)
Similarity:	267/655 - (40%)	Gaps:	110/655 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 PFPEYKTQSIKK-SRLIL---------PHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQT 298
            |.|::|...:.: .|.||         |:..:...:|.:.:..|..:...::|....|   ..||
Zfish   727 PVPQFKIPQMPEWLRAILAYRFPSSIDPYTDLIYVVWLFFVTFAWNWNVWLIPVRCTF---PYQT 788

  Fly   299 K-------VSDVIVEALFIVDI-LLNFRTTFVSRKGEVVSNSKQIAINYLR-GWFALDLLAALPF 354
            .       :.|...::::|:|| ::..|..|| |.|::|.:...:..||.: ..|.:|:::..|.
Zfish   789 PDNIHWWLLMDYFCDSIYIMDIFVVQPRLQFV-RGGDIVCDKNDMRENYRQTERFKMDVISLFPL 852

  Fly   355 DHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDR--------YSQHTAMILTLLMFSFTLAAH 411
            |.||   ::.|..|   |::..|||:.....:..||        |..........|::|.    |
Zfish   853 DVLY---VFTGVKS---LLRFPRLLKYNAFFEFNDRLEAWMSKAYIYRVIRTSAYLLYSL----H 907

  Fly   412 WLACIWYVIAVKEYEWFPE-SNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNV 475
            ..|||:|        |..: ..:|..:.:...|..|         |....||...:|.::| |..
Zfish   908 CNACIFY--------WGSDYEGLGSTKWVYNGKGNS---------YIRCYYFAVKTLITIG-GLP 954

  Fly   476 SANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQ 540
            ...|..|.||.::...:|....:::.|.:..:|....:..:.|.........::..:.:|::::.
Zfish   955 DPTTVFEIVFQLVNYFVGVFAFSIMIGQMRDVIGAATAGEAYYRHSVDSTVKYMTSYRIPRDVQN 1019

  Fly   541 RIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKT 604
            ||:.::..:|.....:|..|.|.:.|:::|.|::..::..|: ::.:|:...:..:..:...:|:
Zfish  1020 RIKTWYDYTWKSQGMLDEQELLIQLPDKMRLDIAADVNYSIVSKVALFQGCDRQMIFDMLKRLKS 1084

  Fly   605 NFCAPGEYLIHKGDALNYIYYLCNGSMEVI--KDDMVVAI-LGKGDLVGSDINVHLVATSNGQMT 666
            ....||:::..||:....:|.:..|.::|:  .|...|.: |..|.:.|   .:.|:|...|.
Zfish  1085 VVYLPGDFVCEKGEIGREMYIIKAGEVQVVGGPDGKTVFVTLRAGSVFG---EISLLAGGGGN-- 1144

  Fly   667 ATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLR---- 727
                        |.::::||..:.:|..:....|.|:|..|||.|:......:..||.:.:
Zfish  1145 ------------RRTANVKAHGFANLFILDKKDLAEILVHYPESQKLLRKKAKKMLTKDKKPAEA 1197

  Fly   728 EGYENQDSDIGPSFP-LPSISE------DDENREEAEEGGKGEKENGGGPPSGASPLHNI-SNSP 784
            :|......::.|..| .|.:.:      ..:.....:|..||.......|.||.|....: ..||
Zfish  1198 KGEVKDTGEVIPQRPETPKLYKAALEVATGQTFSRLKEAYKGATLEPSTPISGMSSTGPVPPPSP 1262

  Fly   785 LHATRSPLLGMGSPRNQRLHQRGR------SLITLRETNK--RHRTLNAACSLDRGS---FEEPE 838
            :| .|||:     ||.|.|.:...      |.:.:|.|.:  ....|:...|...|:   .|||:
Zfish  1263 MH-RRSPI-----PRPQILDEDDMVSETTDSTVIIRMTPRVEGEEILSVEISPAEGAEAEMEEPQ 1321

  Fly   839 PLEEE 843
            ..|::
Zfish  1322 KTEDK 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	55/248 (22%)
		Ion_trans_2	<455..510	CDD:285168	13/54 (24%)
		Crp	583..>650	CDD:223736	13/69 (19%)
		CAP_ED	586..715	CDD:237999	28/131 (21%)
cngb1a	XP_696619.6	ATP-synt_B	<384..450	CDD:304375
		Ion_trans	780..992	CDD:278921	54/243 (22%)
		Crp	1060..>1188	CDD:223736	29/144 (20%)
		CAP_ED	1066..1175	CDD:237999	25/125 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840