DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Elk and kcnh2a

DIOPT Version :9

Sequence 1:NP_477009.1 Gene:Elk / 37047 FlyBaseID:FBgn0011589 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_021336554.1 Gene:kcnh2a / 563802 ZFINID:ZDB-GENE-070912-699 Length:1254 Species:Danio rerio


Alignment Length:1401 Identity:407/1401 - (29%)
Similarity:629/1401 - (44%) Gaps:378/1401 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:||||||||||..:|:|.:..|::.||:.....|::|:|||..:.||:|:::|||.|:
Zfish     1 MPVRRGHVAPQNTFLDTIIRKFEGQNRKFIIANARVENCAIIFCNDGFCGMCGYTRSEVMQKPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH- 129
            |.|||||.|......|:.|:|....|.|:|:..|:|:|....||.|:||:|||...|::|:.:. 
Zfish    66 CSFLYGPHTGRPAVAQMAKALLGSEERKVEISLYRKDGVCLPCLVDVVPVKNEDGLVIMFILNFE 130

  Fly   130 --------------KDITHTKML------------------------EMNVNEECDSVFALTAAL 156
                          :||.:...:                        :.:::|:.:..|......
Zfish   131 LADQQDRPLDSSPGRDINNKNPIPWLSKARRRRLRLPLPLLHSLSGSKQSLHEDTEKGFMQPMPH 195

  Fly   157 LGARFRAGSNAGMLGLGGLPGLGG--------PAASDGDTEAGEG-----------------NNL 196
            :|....|...  :|.|.....|||        .|.::.::|....                 :||
Zfish   196 MGHESVALDK--LLSLPERSALGGSQLLFWEDKAQTESESELRPSEVSPPLPQGFSQSSPRLHNL 258

  Fly   197 D---VPAGCNMGRRRS----------------------------------RAVLYQLSG------ 218
            .   .|:.|:|...||                                  :|.|...:.      
Zfish   259 TSEASPSSCSMAHSRSCESLCGMRPSPSTNDFNWDRKLPVRPSSTGAMHRKASLQNATSDSDLIR 323

  Fly   219 ------------------------------------------HYKPEKGGVKTKLKLGNNFMHST 241
                                                      |...||  |...|.||.:.:   
Zfish   324 LRSSGRGTQISHNLIDMKPDALIAVPTGEIDIIAPCKLIDRTHNVTEK--VTQVLSLGADVL--- 383

  Fly   242 EAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK------- 299
                ||||.|:.:..:..:.||..||.:||||||:...|.|:..||:|||..:|.:.:       
Zfish   384 ----PEYKLQAPRIHKWTILHYSPFKAVWDWVILLLVIYTAIFTPYSAAFLLSDEEEEVIQRCGY 444

  Fly   300 ------VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLY 358
                  |.|:||:.:|:|||::|||||:|:...||||...:||::|.:|||.:|::||:|||.| 
Zfish   445 SCSTLNVVDLIVDIMFVVDIVINFRTTYVNSNDEVVSQPGRIAVHYFKGWFLIDMVAAIPFDLL- 508

  Fly   359 ASDLYDGED------SHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIW 417
               :|..|:      :.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.||||||||
Zfish   509 ---IYRSEEETTTSTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIW 570

  Fly   418 YVIAVKEYEWFPESNIGWLQLLAER----KNASV--AILTTAETYSTALYFTFTSLTSVGFGNVS 476
            |  |:...|....|.||||..|.::    .|:||  :..:..:.|.|||||||:|||||||||||
Zfish   571 Y--AIGNVERSGPSRIGWLNSLGDQLGKPYNSSVRGSGPSIKDKYVTALYFTFSSLTSVGFGNVS 633

  Fly   477 ANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQR 541
            .||.:||:|:|.:|||||||:|.:||||:|||||:||..:.|.::...:::|:..|.:|..|:||
Zfish   634 PNTNSEKIFSICVMLIGALMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQR 698

  Fly   542 IEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTN 605
            :|:|||.:||.::|||:...|:.|||.|:.|:.:||:|.:|| ...|:.:|:|||:.|::..||.
Zfish   699 LEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRTLLQSCKAFKGSSKGCLRALAMKFKTT 763

  Fly   606 FCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTN 670
            ...||:.|:|.||.::.:|::..||:|::|.|:|||||||.|:.|..||.:.             
Zfish   764 HAPPGDTLVHAGDVISALYFISRGSIEILKGDVVVAILGKNDIFGEPINSYA------------- 815

  Fly   671 SAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDS 735
            ..|     :||:|::|||||||..||...::|||.:|||:...|.:::  ::|.|||:    .::
Zfish   816 RPG-----KSSADVRALTYCDLHKIHRDDVLEVLEMYPEFSDYFWSNL--EITFNLRD----TNT 869

  Fly   736 DIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRN 800
            ..|      |:|.|.:           :.:|||..               |.||...|...|.||
Zfish   870 KAG------SMSSDPD-----------DSDNGGLD---------------HHTRRAKLFFQSKRN 902

  Fly   801 -------QRLHQR-GRSLITLRETNKRHRTLNAACSLDRGS--FEEPEPLEEEQSSGGKRPSLER 855
                   :|...| .|.....:.:.|:|.....|   .|.|  |......:||:.:  :|||: .
Zfish   903 SISRADTERTEDRLNRMTFRTQTSGKQHENRQTA---HRSSDIFASQSSSDEEEET--QRPSV-M 961

  Fly   856 LDSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAV 920
            :|...|.:            |::|       .:|....|:|..        :.:.::|..|||:.
Zfish   962 VDCSQSHI------------NSVS-------NANRDKDHNSSN--------SFNALSGAFSGVSN 999

  Fly   921 EHGLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKA--------PSPVEPKKTMTSR 977
            ...|.|.          .....|..||....:..|:|:..|:..        .|.||.:..|..|
Zfish  1000 IFSLWGD----------SSRGHHYQEVPSHSMSFPSSSVPSNTVLHNVTYGQCSEVENRLEMMHR 1054

  Fly   978 SSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDH 1042
                ..||::           .|:...:..|       |.|| |:|.:|:.|  ......||:: 
Zfish  1055 ----QLYRLE-----------KRMSKDIGAI-------MQLL-QRQMVQVPP--AYSSVTSPTE- 1093

  Fly  1043 NLASSKERLITSSAVPTPGR--IYP--PLDDENSNDFRWTMKHSASHHSCCKSTDA--------L 1095
                      .|...|.||:  :.|  ||:.|..:.....:.......|..|::::        |
Zfish  1094 ----------ASPIPPKPGQKLVQPVNPLETETPSILSEILDPHDFADSPIKASESLSGAMELQL 1148

  Fly  1096 LSPEEQPPISILPVDATPAPSVQEVRSSKRSLRKSTSGSNSS------LSSSSSSSNSCLVSQST 1154
            |....|||      ...|:.:.....|...|...:|:|..::      .:.:..:..|.|.::..
Zfish  1149 LDCSSQPP------SENPSGAYMGRWSRSVSHHTNTTGDPTAHIHLQQTAIADQAHYSFLDAEPI 1207

  Fly  1155 GNLTTTNA--SVHCSNSSQSVASVATTRRASWKLQH 1188
            |.|....|  |:|...|..|       ||.|..::|
Zfish  1208 GTLRQPQAVQSLHLETSECS-------RRQSLPVKH 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ElkNP_477009.1 PAS 36..132 CDD:238075 38/110 (35%)
PAS_3 41..129 CDD:285623 38/87 (44%)
Ion_trans 285..516 CDD:278921 124/255 (49%)
Ion_trans_2 <455..510 CDD:285168 40/54 (74%)
Crp 583..>650 CDD:223736 29/67 (43%)
CAP_ED 586..715 CDD:237999 50/128 (39%)
kcnh2aXP_021336554.1 PAS_9 29..130 CDD:315989 41/100 (41%)
Ion_trans 407..670 CDD:306908 130/268 (49%)
CAP_ED 744..855 CDD:237999 50/128 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578362
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0498
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D247304at2759
OrthoFinder 1 1.000 - - FOG0000148
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X71
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.750

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