DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and hcn4

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_686078.4	Gene:	hcn4 / 557843	ZFINID:	ZDB-GENE-050420-360	Length:	1140	Species:	Danio rerio

Alignment Length:	1224	Identity:	278/1224 - (22%)
Similarity:	463/1224 - (37%)	Gaps:	343/1224 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PIKNEKR-DVVLFLASHKDITHTKMLEMNVNEECDSVF--ALTAALLGARFRAGSNAGMLGLGGL 175
            |:|.... |...|..|...||...:.:.:|.||...:.  .:|.:       ..|..|..|.|..
Zfish    67 PVKTSSNGDCRRFRGSLSSITSRHVHDSDVAEERRLITDGEVTPS-------EESPPGAAGGGAE 124

  Fly   176 PGL--GGPAASDGDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKL------- 231
            ||.  ||   ..|:..||...:..:|.              |.:|..|.|  |::..|
Zfish   125 PGAQSGG---GGGEEAAGSSQHQGIPD--------------QQAGFIKLE--GIEQILPDDERYY 170

  Fly   232 KLGNNFMH--------------------STEAPFPEYKTQSIKKSRLILPH-YGVFKGIWDWVIL 275
            :.|  |||                    |.:|  .|.:.:.:|.:...:.| |..|:..||..:|
Zfish   171 QAG--FMHRQFGAMLQPGVNKFSLRMFGSEKA--VEREQERVKSAGFWIIHPYSDFRFYWDLTML 231

  Fly   276 VATFYVALMVPYNAAFAKADRQTK---VSDVIVEALFIVDILLNFRTTFVSR-KGEVVSNSKQIA 336
            :......:::|....|.| |..|.   |.:|:.:..|::|::|||||..|.. ..|::.:.:||.
Zfish   232 LLMVGNLIIIPVGITFFK-DEHTPPWIVFNVVSDTFFLMDLVLNFRTGIVKEDNAEIILDPQQIK 295

  Fly   337 INYLRGWFALDLLAALPFDHLYA-------SDLYDGEDSHIHLVKLT------RLLRLARLLQKI 388
            |.|||.||.:|.::::|.|:::.       ||.|....: :.:|:.|      |||||:||::.|
Zfish   296 IKYLRSWFVVDFISSIPVDYIFLIVETRIDSDFYKTARA-LRIVRFTKILSLLRLLRLSRLIRYI 359

  Fly   389 DR--------YSQHTAMI-LTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWLQLLAERKN 444
            .:        |...:||: :..|:....|..||..|:.:::.:  .:.||..  .|:     .||
Zfish   360 HQWEEIFHMTYDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPM--LQDFPAD--CWV-----AKN 415

  Fly   445 ASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQ 509
            ..|.. |..:.||.||:...:.:..:|:|........:...||:.|::||..:|:..|:.||:||
Zfish   416 KMVND-TWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQ 479

  Fly   510 RMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-V 573
            .:.|.|..|:.|::.::.:::.|.:|.:::|||.||::..:. ....|....|.|..|.||.: :
Zfish   480 SLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQ-GKMFDEESILGELNEPLREEII 543

  Fly   574 SMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDM 638
            :.:..:.:..:|:|..|....:..:...::.....||:|:|.:|.....:|::.:|
Zfish   544 NFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHG--------- 599

  Fly   639 VVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVV----RSSSDIKALTYCDLKCIHMGG 699
            ||::|.||               |.:...:..|...::.:    |.::.::|.|||.|..:.:..
Zfish   600 VVSVLTKG---------------NKETKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDN 649

  Fly   700 LVEVLRLYPEYQQQF---AND-----------IQHDLTCNLREGYEN-QDSDIGPSFPLPSISED 749
            ..|||..||..::.|   |.|           :||.:..:|..|..| |:|:|     :..|.:.
Zfish   650 FNEVLEEYPMMRRAFETVALDRLDRIGKKNSILQHKVQHDLNSGVLNYQESEI-----IQQIVQH 709

  Fly   750 DENREEAEEGGKGEKENGGGPPSGA----SPLHNISNSPLHAT---------------------R 789
            |  |:.|......:..:...|||..    :||   ..:||.|.                     |
Zfish   710 D--RDMAHCANLLQSPSPPAPPSPTPVIWAPL---IQAPLQAAAATTSVAIALTHHPHLPATLFR 769

  Fly   790 SPLLGMGSPRNQ---RLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRP 851
            .|:..:|| ||:   ||              ||.:|:.....   .:.:.|.....:..||...|
Zfish   770 PPVSLLGS-RNEPPSRL--------------KRFQTVAPRTG---STTDSPSTSPSKLHSGVDTP 816

  Fly   852 SLERLDSQVST-------------------------------LHQDVAQ-------LSAEVRNA- 877
            .|..|.:|.|:                               ||....|       |||.::.|
Zfish   817 LLASLHTQHSSVTITPSATTNQPVSFRSFSSPSASPTLSTAQLHPQPRQKQPSTPPLSARLQAAG 881

  Fly   878 -------------ISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVL 929
                         .|||.....|.:...|:...|.|...|:...||  |.:||:.:.|
Zfish   882 AHPPGILTTASSNTSALSAGLSTHSPTHSYPPPKHPQTGSLQFASG--GGKSGLTLFH------- 937

  Fly   930 AAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDFPTFERF 994
                        |.||   |..:.:      .|:||......:|..|.||.....|....:..::
Zfish   938 ------------SPPP---GSPISI------HSQAPESSTSSQTQPSFSSYLALERSALASIAQY 981

  Fly   995 VLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLASSKERLIT------ 1053
            ..||.......|.:.|.:::.:    ..:|.|.|         .||  :.|.|...|:.
Zfish   982 GSANASPSYTPLALSPTVQSPV----TGRTFQYS---------DPS--SAAGSHTSLLLPQSSCP 1031

  Fly  1054 -------SSAVPTP-GRIYPPLDDENSNDFRWTMKHSASHHS-----CCKSTDALLSPEEQP--- 1102
                   ||...:| ||.|     |:.|..      |:||.|     ..:|:...|||...|
Zfish  1032 GQLPGHHSSGTDSPLGRFY-----EDLNIL------SSSHPSLGVEGAGQSSPGYLSPYLSPTLT 1085

  Fly  1103 --PISIL------PVDATPAPSVQEV---RSSKRSLRKSTSGSNSSLSSSSSSS 1145
              |.|.:      ||..:|.|..|.:   .|...||.:::.|....|.|...|:
Zfish  1086 PKPCSSVSGHMSSPVQTSPGPRGQALSVGTSPALSLPRTSDGDLEPLRSKLPSN 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	5/18 (28%)
		PAS_3	41..129	CDD:285623	4/15 (27%)
		Ion_trans	285..516	CDD:278921	73/256 (29%)
		Ion_trans_2	<455..510	CDD:285168	16/54 (30%)
		Crp	583..>650	CDD:223736	15/66 (23%)
		CAP_ED	586..715	CDD:237999	28/135 (21%)
hcn4	XP_686078.4	Ion_trans_N	179..221	CDD:285597	6/43 (14%)
		Ion_trans	241..486	CDD:278921	73/256 (29%)
		Crp	550..>685	CDD:223736	32/158 (20%)
		CAP_ED	556..664	CDD:237999	27/131 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740