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Protein Alignment Elk and hcn2b

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_685414.3	Gene:	hcn2b / 557285	ZFINID:	ZDB-GENE-030131-8228	Length:	979	Species:	Danio rerio

Alignment Length:	951	Identity:	209/951 - (21%)
Similarity:	395/951 - (41%)	Gaps:	173/951 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SHKDITHTKMLEMNVNEEC---DSVFALTAAL---LGARFRA----GSNAGMLGLGGLPGLGGPA 182
            :|.|......:...:|.:|   |||.::.:.|   .|..|.|    .|.:.|.|.........|.
Zfish    69 AHSDGEDATGMRCVINGDCRRDDSVCSVLSKLEKQTGGGFPASACHSSTSSMDGSVTPAAAAAPP 133

  Fly   183 ASDGDTEA-------GEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVK-----------T 229
            |...|:..       ..|.:...|||.::...:|.      .|....|.|..:           .
Zfish   134 ADKKDSRVSFSSAAPAHGPSPSNPAGNSVSFSKSE------DGQITAEDGEARDNQTYMQRQFSA 192

  Fly   230 KLKLG-NNF---MHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAA 290
            .|:.| |.|   |..::....:.:.:.......|:..|..|:..||:.:|:......:::|....
Zfish   193 MLQPGVNKFSLRMFGSQKAVEKEQERVKSAGNWIIHPYSDFRFYWDFTMLMFMVGNLIIIPVGIT 257

  Fly   291 FAKADRQTK--VSDVIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALDLLAAL 352
            |.|.:..|.  :.:|:.:..|::|::|||||..|.... |::.:.::|...||:.||.:|.::::
Zfish   258 FFKEETTTPWIIFNVVSDTFFLMDLVLNFRTGIVYEDNTEIILDPEKIKKKYLKTWFVVDFVSSI 322

  Fly   353 PFDHLYASDLYDGEDSHIH-------------LVKLTRLLRLARLLQKIDRYSQ---------HT 395
            |.|:::.. :..|.||.::             ::.|.|||||:||::.|.::.:         ..
Zfish   323 PVDYIFLI-VEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 386

  Fly   396 AMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTAL 460
            .|.:..|:....|..||..|:.:::.:  .:.||..  .|:.|     |..|.. :.:|.||.||
Zfish   387 VMRIINLIGMMLLLCHWDGCLQFLVPM--LQDFPSD--CWVSL-----NKMVND-SWSELYSFAL 441

  Fly   461 YFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDL 525
            :...:.:..:|:|..:..:.::...|::.|::||..:|:..|:.||:||.:.|.|..|:.|::.:
Zfish   442 FKAMSHMLCIGYGRQAPESMSDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQV 506

  Fly   526 KDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-VSMHLHREILQLPIFEA 589
            :.:::.|.:|.:.:|:|.||::..:. ....|....|.|..|.||.: |:.:..:.:..:|:|..
Zfish   507 EQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEESILEELNEPLREEIVNFNCRKLVASMPLFAN 570

  Fly   590 ASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDIN 654
            |....:..:...::.....||:|:|.:|.....:|::.:|         ||::|.||: :|..::
Zfish   571 ADPNFVTAMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHG---------VVSVLTKGN-IGMKLS 625

  Fly   655 VHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQF----- 714
               ..:..|::...|..       |.::.::|.|||.|..:.:....|||..||..::.|
Zfish   626 ---DGSYFGEICLLTRG-------RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAI 680

  Fly   715 -------------ANDIQHDLTCNLREGYENQ--------DSDIGPSFPLPSISEDDENREEAEE 758
                         .:.:||||...:....||:        |.::     :..:.:.|..|..|..
Zfish   681 DRLDRIGKKNSILMHKVQHDLNSGVFNNRENEMIQEIVKYDREM-----VKLVKQGDMQRPRAMS 740

  Fly   759 GGKGEKENGGGP---PSGASPLHNISNSPLHA----TRSPLLGMGSPRNQRLHQRGRSLITLRET 816
            .......:..||   ||.:|.:..:..:...:    ..:||:|.||.::.|:.:|.:.:.|....
Zfish   741 MTPSTHGSMFGPSSQPSTSSAIATLQQAVAMSFCPQMGNPLMGSGSVQSPRMVRRFQVVQTQTPP 805

  Fly   817 NKRHRTLNAACSL----------------DRGSFEEPEPLEEEQS-------SGGKRPSLERLDS 858
            ..::.||..|.:|                ..||.....|...:.|       |...||::.|
Zfish   806 GSQYSTLARASALASTPVHSPLATTARTFQYGSSPPGAPSGSQLSLVQQLVPSPTHRPAVHR--- 867

  Fly   859 QVSTLHQDVAQLSAEVRN-AISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGT-RSGVAVE 921
              |||.||...|||...: ....:|.:..:....|..||....|.:::|..:|:.|: ...:|:.
Zfish   868 --STLTQDARALSASQPSLRPDMIQPVAPSPPQSTRVSSTSIGPPQNLPGPTGLRGSIPPRMALT 930

  Fly   922 HGLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASS 962
            |.:..|....|.|..|:.|         .|..||..::.||
Zfish   931 HQMSVGAFPPASLPQMRPS---------LDSGLPKKDSISS 962

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.