DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and hcn4l

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_684730.5	Gene:	hcn4l / 556759	ZFINID:	ZDB-GENE-110411-3	Length:	1188	Species:	Danio rerio

Alignment Length:	1221	Identity:	270/1221 - (22%)
Similarity:	458/1221 - (37%)	Gaps:	340/1221 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 NVNEEC----DSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTE-AGEGNNLDVPA 200
            |||.:|    .|:.:||:.      .|..:|.:.....|.|...| ..||.:| .|.|.:.....
Zfish    77 NVNGDCRRFRGSLSSLTSR------HAAPDADLAEQRRLIGDASP-EDDGPSEQPGPGESPGAKG 134

  Fly   201 GCNMGRRRSRAV--------------------LYQLSGHYKPEKGGVKTKLKLG-NNF---MHST 241
            |...|.:::.:.                    :|| :|....:.|.:   |:.| |.|   |..:
Zfish   135 GRGDGAQQAPSEEQSTFVKLEGIDQILPDDERMYQ-AGFMHRQFGAM---LQPGVNKFSLRMFGS 195

  Fly   242 EAPFPEYKTQSIKKSRLILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK---VSD 302
            |... |::.:.:|.:...:.| |..|:..||.::|:......:::|....|.| |..|.   |.:
Zfish   196 EKAV-EHEQERVKSAGFWIIHPYSDFRFYWDLIMLLLMVGNLIIIPVGITFFK-DEHTPAWIVFN 258

  Fly   303 VIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALDLLAALPFDHLYA------- 359
            |:.:..|:||::|||||..|.... |::.:.:||.:.|||.|||:|.|:::|.|:::.
Zfish   259 VVSDTFFLVDLVLNFRTGIVKEDSTEIILDPQQIKVRYLRSWFAVDFLSSIPVDYIFLIVETRID 323

  Fly   360 SDLYDGEDSHIHLVKLT------RLLRLARLLQKIDR--------YSQHTAMI-LTLLMFSFTLA 409
            ||.|....: :.:|:.|      |||||:||::.|.:        |...:||: :..|:....|.
Zfish   324 SDFYKTARA-LRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAMVRIVNLIGMMLLL 387

  Fly   410 AHWLACIWYVIAVKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGN 474
            .||..|:.:::.:  .:.||..  .|:     .||..|.. |..:.||.||:...:.:..:|:|.
Zfish   388 CHWDGCLQFLVPM--LQDFPSD--CWV-----AKNKMVND-TWGQQYSYALFKAMSHMLCIGYGM 442

  Fly   475 VSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELK 539
            .......:...||:.|::||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.|.:|.:::
Zfish   443 YPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMR 507

  Fly   540 QRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCLKLLSLHIK 603
            |||.||::..:. ....|....|.|..|.||.: :|.:..:.:..:|:|..|....:..:...::
Zfish   508 QRIHDYYEHRYQ-GKMFDEESILGELNEPLREEIISFNCRKLVATMPLFANADPNFVTSMLTKLR 571

  Fly   604 TNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTAT 668
            .....||:|:|.:|.....:|::.:|.:.|:........:..|...|     .:...:.|:.||:
Zfish   572 FEVFQPGDYIIREGTVGKKMYFIQHGVLTVLTKGSKETKISDGSYFG-----EICLLTRGRRTAS 631

  Fly   669 TNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQF------------------A 715
                           ::|.|||.|..:.:....|||..||..::.|                  .
Zfish   632 ---------------VRADTYCRLYSLSVDHFNEVLEEYPMMRRAFETVALDRLDRIGKRNSVLQ 681

  Fly   716 NDIQHDLTCNLREGYENQ--------DSDIG-----------PSFPLPSISEDDENREEAEEGGK 761
            :.:|.||...:....||:        |.|:.           |..|.|:
Zfish   682 HKVQRDLNSGVLNYQENEIIQQIVQHDRDMAHCAHLMQTPPPPPHPAPT---------------- 730

  Fly   762 GEKENGGGPPSGASPL--HNISNSPLHAT---------------------RSPLLGMGSPRNQRL 803
                     ||..:|:  ..:..:||.|.                     |.|:..:||.::|..
Zfish   731 ---------PSSHTPVIWAPLIQAPLQAAAATTSVAIALTRHPHLPHTLFRPPVPRLGSLKDQPG 786

  Fly   804 HQRGRSLITLRETNKRHRTLNAACSLDRGS----------FEEP--EPLEEEQSS-GGKRPSLER 855
            :            .||..|..:......||          .|.|  :.|..|:|| ....||...
Zfish   787 Y------------FKRFPTALSGADTFGGSSSTSSQFSSCIETPILDTLRAERSSTSTPPPSSSS 839

  Fly   856 LDSQVSTLHQDVAQLSAEVRNAISALQEMT-FTSNAMTSHSSLKF-------PPARSIPNISGVA 912
            |.|.::|          .|....|::.|.: :....:.||.|..|       .|..|..:.|.:|
Zfish   840 LPSTITT----------TVTTTTSSITESSVYHHRPIISHGSKDFSVAQLHSQPQLSQASFSSIA 894

  Fly   913 GTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP-------------------PEVWGRDVQLPTS- 957
            .:..|. .:.|..||  .|..||....|:..|                   |:        ||.
Zfish   895 ASLPGF-FQQGAAGG--EAVHLAVPPASTLTPLIAHSVSPILTQLHATHSNPQ--------PTKP 948

  Fly   958 ----NTASSKAP------SPVEPKKTMTSRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAI 1012
                |.|...||      |||..|..:....|.|....           .:|:     :||:|.:
Zfish   949 IQDLNKAGRTAPQSPVTESPVHSKSILEQVQSPTSVQS-----------QHPQ-----IGIQPDV 997

  Fly  1013 KNEMDLLQQKQTL---------QISPLNT----IDECVSPSDHNL---ASSKERLITSS--AVPT 1059
            .::  |.|:...|         ..||.:|    ...|.||:...:   |.|:...|:.|  ::.|
Zfish   998 LSQ--LAQEPSALASLAQYGSGNASPCSTPSAWSPTCQSPTAEKMRMSAHSQPSSISGSQTSLLT 1060

  Fly  1060 PGRIYPP----------LDDENSNDF--------------------RWTMKHSASHHSCCKSTDA 1094
            |..::||          |.|..|.|.                    |.......|||   :.:.:
Zfish  1061 PQTLFPPPPQPRERGGSLVDLPSQDLSTLSMSLPIPGLAEKSRAVGRGPQPPDLSHH---RGSTS 1122

  Fly  1095 LLSPEEQPPISILPVDATPAPSVQEVRSSKRSLRKSTSGSNSSLSSSSSSS 1145
            ..||...||..:.|..:.|...|...::||.|:.::.|...|....||..|
Zfish  1123 GYSPLPSPPPLVNPFSSIPGHVVLSRQTSKLSITQTGSSGGSPAHGSSDRS 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	75/256 (29%)
		Ion_trans_2	<455..510	CDD:285168	16/54 (30%)
		Crp	583..>650	CDD:223736	12/66 (18%)
		CAP_ED	586..715	CDD:237999	26/146 (18%)
hcn4l	XP_684730.5	Ion_trans_N	177..219	CDD:285597	11/45 (24%)
		Ion_trans	239..484	CDD:278921	75/256 (29%)
		Crp	548..>683	CDD:223736	27/154 (18%)
		CAP_ED	554..662	CDD:237999	25/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840