DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh4

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001074663.1	Gene:	Kcnh4 / 380728	MGIID:	2156184	Length:	1018	Species:	Mus musculus

Alignment Length:	1098	Identity:	473/1098 - (43%)
Similarity:	628/1098 - (57%)	Gaps:	195/1098 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQA-NGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.|||. .|.|||||||||.:||||.|.::|||.|
Mouse     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.|||||:|.|...|:::|:|....|.:.|:.||:|:|:.||||.|::|||||..:|||||.|.
Mouse    66 SCRFLYGPETSEPALQRLQKALEGHQEHRTEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            |||:.:                                     || ||||.|...      |:.|
Mouse   131 KDISQS-------------------------------------GG-PGLGSPGIH------GDNN 151

  Fly   195 NLDVPAGCNMGR-----------RRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEY 248
            :.:     ::||           |::|.||::|:||: ..:|....|   .|:.:...:...|||
Mouse   152 HEN-----SLGRRGTSSRLRSTKRQNRTVLHRLTGHF-GRRGQSSVK---ANSNLFEPKPSVPEY 207

  Fly   249 KTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD------RQTKVSDVIVEA 307
            |..|:..||.:|.||.:.|.:||.:||:||||||:.||||..||..|      |.|.|||:.||.
Mouse   208 KVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEM 272

  Fly   308 LFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHL 372
            |||:||:||||||:||:.|:|:|..:.|.::||..||.:||:||||||.||..::  ...|.:||
Mouse   273 LFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFVDLIAALPFDLLYVFNI--TVTSLVHL 335

  Fly   373 VKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPES 431
            :|..|||||.|||||::||||.:|::|||||..|.|.|||:||:||||..:|.|      |
Mouse   336 LKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLW---- 396

  Fly   432 NIGWLQLLAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            :||||..|.:|     .|.|....:....|..|||||.:||||||||||.|||.|||:|:|..||
Mouse   397 DIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTML 461

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            |||||||||||||||||||||||||||.|:.:|||||:.:|.:|:.||||:.:||||:|:::.||
Mouse   462 IGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGI 526

  Fly   557 DIYETLREFPEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALN 621
            |..|.||:||:|||.|::|||:|||||||:|.|||:|||:.|||||||:||||||||:.:||||.
Mouse   527 DANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQ 591

  Fly   622 YIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKA 686
            ..||:|:||:||::|:||:||||||||:|:||      ...||...  :.||...|:::|:|:||
Mouse   592 AHYYVCSGSLEVLRDNMVLAILGKGDLIGADI------PELGQEPG--SGAGPSCVLKTSADVKA 648

  Fly   687 LTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYEN---------------QDSD 736
            ||||.|:.:...||.|||||||||...|...:..|||.|||:|.||               :...
Mouse   649 LTYCGLQQLSSRGLAEVLRLYPEYAAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDT 713

  Fly   737 IGPSF--PLPSISEDDENREEAEEGGKGEKEN--------GGGPPSGA---------SPLHNISN 782
            :|.|.  .||||:|    .|...|.|.|.|..        ....|.|:         .|...:.:
Mouse   714 LGSSSDKTLPSITE----TEGGTEPGAGSKPRRPHLLPNLSPARPRGSLVSLLGEELPPFSALVS 774

  Fly   783 SP-LHATRSPLLG--------MGSPRNQRLHQRGRSLI----TLRETNKRHRTL----NAACSLD 830
            || |..|.||.|.        .|.||.....:..:.||    |....:...|.:    :::.:.:
Mouse   775 SPSLSPTPSPALAGRGQSPSPHGPPRGSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSSNTAE 839

  Fly   831 RGSF---EEPEPLEEEQSS--GGKRPSLE--------------RLDSQVSTLHQDVAQLSAEVRN 876
            ..:|   :.|||......:  .|.|.|.|              ||:.::|.|:|:|:|||.|:|.
Mouse   840 APTFRFSKRPEPTRTRSQAPPSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQ 904

  Fly   877 AISALQEMTFTSNAMTSHSS-------LKFPPARSIPNIS-GVAGTRSG-----VAVEH--GLMG 926
            .:..||...    ...||::       |..|..| :|.|| .::|...|     :||.|  ..:|
Mouse   905 VMGLLQARL----GPPSHTAGPAWLPDLPCPHQR-LPCISPHMSGPPPGLQNTTLAVVHCPASVG 964

  Fly   927 GVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFY 984
            .|...|..:.: |.|:.||.....|   |...:.:.:|| |:.|.....|..|.:|.:
Mouse   965 TVEIGATPSEL-RPSTIPPYPSEPD---PLGPSPAPEAP-PLTPSLLKHSFQSGSDTF 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	54/96 (56%)
		PAS_3	41..129	CDD:285623	50/87 (57%)
		Ion_trans	285..516	CDD:278921	140/247 (57%)
		Ion_trans_2	<455..510	CDD:285168	43/54 (80%)
		Crp	583..>650	CDD:223736	47/66 (71%)
		CAP_ED	586..715	CDD:237999	72/128 (56%)
Kcnh4	NP_001074663.1	PAS_9	29..135	CDD:290162	61/105 (58%)
		PAS	42..133	CDD:238075	52/90 (58%)
		Ion_trans	244..486	CDD:278921	140/247 (57%)
		Ion_trans_2	<426..480	CDD:285168	43/53 (81%)
		CAP_ED	556..676	CDD:237999	72/127 (57%)
		bZIP	<864..902	CDD:304365	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835159
Domainoid	1	1.000	278	1.000	Domainoid score	I1692
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I514
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm42392
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760