DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and KCNH2

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_000229.1	Gene:	KCNH2 / 3757	HGNCID:	6251	Length:	1159	Species:	Homo sapiens

Alignment Length:	1134	Identity:	366/1134 - (32%)
Similarity:	539/1134 - (47%)	Gaps:	265/1134 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:||||||||||..:|:|....|::.||:.....::||:|||.:|.|||||::||:.|:
Human     1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||:||.|:.....||.::|....|.|:|:.||:|:|:.|.||.|:||:|||...|::|:.:.:
Human    66 CDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNE---------------------ECDSVFALTAALLGARFRAGSNAG------ 168
            .:....|:....::                     :..::.||||.....|......||
Human   131 VVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVV 195

  Fly   169 --------------------------MLGLG------GLPGLGGPAAS-DGDTEAGEGNNLDVPA 200
                                      :.|||      .|.|.|.|..| .|...:...::|:..|
Human   196 VDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDA 260

  Fly   201 ---GCNMGRRRSR--------------------AVL-----YQLSGHYKPEKGGV---------- 227
               .|::.|.|||                    .||     :..:|...|.:.|:
Human   261 SGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLV 325

  Fly   228 --KTKLKLGN---NFMHSTEAPF-------------------------------------PEYKT 250
              :|..|:..   ||:.....||                                     ||||.
Human   326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKL 390

  Fly   251 QSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAF--------------AKADRQTKVS 301
            |:.:..|..:.||..||.:|||:||:...|.|:..||:|||              ..|.:...|.
Human   391 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVV 455

  Fly   302 DVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGE 366
            |:||:.:||||||:|||||:|:...||||:..:||::|.:|||.:|::||:|||.|...   .|.
Human   456 DLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFG---SGS 517

  Fly   367 DSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPES 431
            :..|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|.... :|
Human   518 EELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHM-DS 581

  Fly   432 NIGWLQLLAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            .||||..|.::     .::.:...:..:.|.|||||||:|||||||||||.||.:||:|:|.:||
Human   582 RIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            ||:||:|.:||||:|||||:||..:.|.::...:::|:..|.:|..|:||:|:|||.:||.::||
Human   647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGI 711

  Fly   557 DIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDAL 620
            |:...|:.|||.|:.|:.:||:|.:|| ...|..|::|||:.|::..||....||:.|:|.||.|
Human   712 DMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLL 776

  Fly   621 NYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHL-VATSNGQMTATTNSAGQDVVVRSSSDI 684
            ..:|::..||:|:::.|:|||||||.|:.|..:|::. ...|||                   |:
Human   777 TALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG-------------------DV 822

  Fly   685 KALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISE- 748
            :|||||||..||...|:|||.:|||:...|.:.:  ::|.|||      |:::.|..|..:..|
Human   823 RALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLR------DTNMIPGSPGSTELEG 879

  Fly   749 ----------------DDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSP------ 791
                            |.:..:..|....|....|.||.|...|......||.....||
Human   880 GFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDE 944

  Fly   792 ----------LLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRG-------------- 832
                      |:...|||.......|..|  :.:..|...|.|.......|
Human   945 GPGRSSSPLRLVPFSSPRPPGEPPGGEPL--MEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGR 1007

  Fly   833 SFEE--------PEPLEEEQSSGGKRPSLE---RLDSQVSTLHQDVAQLSAEVRNAISALQ-EMT 885
            .::|        |..|....||.|:||..:   |||:....|::...:|||::...:..|| :||
Human  1008 QYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMT 1072

  Fly   886 FTSNAMTSHSSLKFPPARSIPNISGVAGT 914
            ..            |||.|.....|...|
Human  1073 LV------------PPAYSAVTTPGPGPT 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	41/95 (43%)
		PAS_3	41..129	CDD:285623	41/87 (47%)
		Ion_trans	285..516	CDD:278921	121/249 (49%)
		Ion_trans_2	<455..510	CDD:285168	39/54 (72%)
		Crp	583..>650	CDD:223736	29/67 (43%)
		CAP_ED	586..715	CDD:237999	50/129 (39%)
KCNH2	NP_000229.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..314		17/82 (21%)
		Ion_trans	409..668	CDD:306908	126/262 (48%)
		Selectivity filter. /evidence=ECO:0000250	624..629		4/4 (100%)
		CAP_ED	742..853	CDD:237999	50/129 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..982		21/113 (19%)
		SSTK-IP	1012..1113	CDD:318128	24/90 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1038		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1159
		PAS_9	29..130	CDD:315989	44/100 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750